Conserved Protein Domain Family
7tmA_GPR61_GPR62-like

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cd15220: 7tmA_GPR61_GPR62-like 
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.
Statistics
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PSSM-Id: 320348
View PSSM: cd15220
Aligned: 8 rows
Threshold Bit Score: 208.052
Threshold Setting Gi: 296434526
Created: 7-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##              ######
gi 296434526  16 LGLILAAVVEVGALLGNGALLVVVLRTPGl--rDALYLAHLCVVDLLAAASIMPLGLLAApppglgrvrlgpapCRAARF 93
gi 229289086  25 AMISVMTITDVLAIAGSISVMAVIAKTPQlrilTLIFVFNLCAADLMHSLSSTPLAIATLahggew--fstvpmCQMTGF 102
gi 449274936   8 VGLLCMVLLTLTALVANTLVMVVILKTPLl--rKFIFVCHLCVVDLLSAIFLMPLGIISSsscfnrv-iysiaeCKGMIF 84
gi 47229630   33 LALAAMLLMDLLAVVGNVAVMAVIAKAPQl--hKFAFVFHLCVVDLLAALVLMPLGMLSGraff------gealCRSYLF 104
gi 2495034    48 FGLFCMVTLNLIALLANTGVMVAIARAPHl--kKFAFVCHLCAVDVLCAILLMPLGIISSspffgtv-vftileCQVYIF 124
gi 125829811  50 SGLVVMVTLNAIALIANSAVLAIVVKVPHl--rKFSLVCHLCIVDLLCAALLMPLGIVCGspffagv-vfsvleCRLYIF 126
gi 224084842  37 VGLFFMVLLDLTAIVGNAAVMTVIAKTPAl--rKFVFVFHLCLVDFLAALTLMPLEMLSGsavfesp-glgeavCRVYLF 113
gi 76789653   44 VALFFMLLLDLTAVAGNAAVMAVIAKTPAl--rKFVFVFHLCLVDLLAALTLMPLAMLSSsalfdha-lfgevaCRLYLF 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 296434526  94 LSAALLPACTLGVAALGLARYRLIVhplr---pgsrPPPVLVLTAVWAAAGLLGALSLLgtppapppap----------- 159
gi 229289086 103 LDSFFTFGSISTVCVISVERYYSIVrpmvhaayltlLKALFAIGVIWLLALAFAMAPLMgwngysfnpiqk--------- 173
gi 449274936  85 LNVCFISASILTISIISVERYYYIVhpmryevkmtiRLALAGMVFIWVKSVLITILAVVswplgngatsas--------- 155
gi 47229630  105 LSVCLVSAAILSISVINVERYYYIVhpmryevrmtvGLVASVLVGVWVKALAMSALPLLawflqsgrtpllesggvggeg 184
gi 2495034   125 LNVFLIWLSILTITAISVERYFYIVhpmryevkmtiNLVIGVMLLIWFKSLLLALVTLFgwppyghqssiaa-------- 196
gi 125829811 127 LNAFLVSASIFTVTVISIERYFYIVhpmryeakmtpWLSAAVMGLVWVASTLLGLATVFgwpsygsrssiaa-------- 198
gi 224084842 114 LSVCLTSMCILSISTINVERYYYVVhplryevrmtaGLVAGVLAGVWLKAVATSLVPVLgwlspdrpptsgt-------- 185
gi 76789653  121 LSVCFVSLAILSVSAINVERYYYVVhpmryevrmtlGLVASVLVGVWVKALAMASVPVLgrvsweegapsvp-------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #  ### ### ##                                           
gi 296434526 160 ---------------arcsvlaggLGPFRPLWALLAFALPALLLLGAYGGIFVVarraalrpprpargsrlh-------- 216
gi 229289086 174 -------------ectfswseggaSTVYAIIISVVYFCIPAMVIITMYGFIYRTarkasrqvgplpapllpvdetqmpsg 240
gi 449274936 156 -------------rctvywspgahKKAFVIIFSIVCFVLPTVLIFAVYCSVYRVarmaslqhvpmpaptqaaaprhrse- 221
gi 47229630  185 aaalypppqghrrcslhwtgggsnRLAFMVLFTLVYFLCPLLVILVVYCNMFKVarvaamhhgplptwmdtprrqrses- 263
gi 2495034   197 ------------shcslhashsrlRGVFAVLFCVICFLAPVVVIFSVYSAVYKVarsaalqqvpavptwadaspakdrs- 263
gi 125829811 199 ------------thcslhwshsghRRVFAILFCTVCFCVPAAIIIAVYGNVYKVahtaarergpipswtiatahpkrrsd 266
gi 224084842 186 ------------rgcslqwsrgpsCKVFVVFFAAFYFVLPLLIILVVYCGMFKVarvaamhhgppptwmetprrrsa--- 250
gi 76789653  193 ------------pgcslqwshsayCQLFVVVFAVLYFLLPLLLILVVYCSMFRVarvaamqhgplptwmetprqrse--- 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            #  ## ##  # 
gi 296434526 217 -------------------------------sdsldsrlsilpplrprLPGGKAALAPALAVGQFAACWLPYGCACLAPa 265
gi 229289086 241 iflqvppatpsqifnvssrvgpapstsmnsltvsgaldggnllgkrqhNEPLKATKTLLLIVGLFLFTWGPYFTASFYLg 320
gi 449274936 222 ------------------------siashvtiittrnlplprltserfLGSNKAIVTLVLIVGQFLCCWLPFFAFHLHSs 277
gi 47229630  264 -----------------------lssrstmvtssgtgsgtgrvtpqrpFGGGKAAAVLVAVGGQFLCCWLPYFTFHLYSa 320
gi 2495034   264 ------------------------dsinsqttiittrtlpqrlsperaFSGGKAALTLAFIVGQFLVCWLPFFIFHLQMs 319
gi 125829811 267 s---------------------vnsqttiittstsvrrnqvprrkrrtLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLs 325
gi 224084842 251 --------------------------slssrstmvttsgaprttpqriFGGGKAAAVLLAVGGQFLFCWLPYFSFQLYTa 304
gi 76789653  258 --------------------------slssrstmvtssgapqttphrtFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVa 311
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
Feature 1                ## ###  #  ##                     
gi 296434526 266 a------rAAEAEAAVTWVAYSAFAAHPFLYGLLQrpVRLAL 301
gi 229289086 321 lvgvkysgVEDAVIWLRILARTSFALNSLVYGLLNrqVRLEL 362
gi 449274936 278 vaa-gtvgGGHGEMVVTWIAYSSFAINPFFYGLLNrqIREEL 318
gi 47229630  321 laasppaaLASMEEVVTWIGYFCFTTNPFFYGCLNrqIREEL 362
gi 2495034   320 ltg-smksPGDLEEAVNWLAYSSFAVNPSFYGLLNrqIRDEL 360
gi 125829811 326 lgi-shstSEEAEGPVTWLAYSTFAVNPFFYGLLNrqIREEL 366
gi 224084842 305 lst-rplaGPAAETVVTWLGFCCFTSNPFFYGCLNrqIRGEL 345
gi 76789653  312 lsa-qpisTGQVESVVTWIGYFCFTSNPFFYGCLNrqIRGEL 352

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