Conserved Protein Domain Family
7tmA_OR51-like

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cd15222: 7tmA_OR51-like 
olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320350
View PSSM: cd15222
Aligned: 78 rows
Threshold Bit Score: 372.989
Threshold Setting Gi: 38372710
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372712   30 IWISIPLCFMYLVSIPGNCTILFIIKTERSLHePMYLFLSMLALIDLGLSLCTLPTVLGIFWvgAREISHdaCFAQLFFI 109
gi 47578045   24 IWLSIPLCTMYFASLAGNSLILWVVKSEPSLHqPMYYFLSMLAVTDLGLSASTMPTMLTIYMlgVSEVPLdmCFAQLFFI 103
gi 47578039   27 CWTAIPICLIYILSVLGNIIIMHIVKSVPSLHtPMYLFLSMLSMADLGLSASTLPSMVAVFLlgQRLIGAaaCFMQLFFI 106
gi 47577375   26 HWVSIPINLICVVSILGNSIILFLIRTDPALHePMFIFLSMLAASDLGLCASTFPTMVRLFWlgTRELPFdfCAAQMFFI 105
gi 47578017   27 IWVSIPFCAMFLITIVGNMTIIIVIWHEQTLHvPMYLILAMLASSDLGLSLFTFPTLLRIFLlnAREVTAsaCFTQMFFI 106
gi 38372710   33 SWWTLPLIAVYLLSALGNGTILWIIALQPALHrPMHFFLFLLSVSDIGLVTALMPTLLGIALagAHTVPAsaCLLQMVFI 112
gi 530650922  27 PWISIPFCSMYLIAMLGNSLILFVIKTQQKLHePMYLFLSMLSVTDLGLSVSTLPTMLSVFVfnTREIGIdvCLAQLFFI 106
gi 557317898  27 AWLSITFSFMFVLALLGNSMVLLVICAEPSLHePMYLFLAMLAAADLGLATSTFLSMLRIFWsgARELSSsaCFTQMFFI 106
gi 514795738  34 MWSAVLLCSVYLLVLLGNWTVLAIIKAEQSLHaPMYLLLAMLAVADLGLSTSVFPTMLRMLWleGREISSstCFSQMFFI 113
gi 390470096  27 IWMSIPFSSVYLLSLMGNFTILLLIKTEQSLHePMYYFLSMLSISDIGLSLSSLPTTLGLFLfdVHEIHAaaCFAQEFFI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372712  110 HCFSFLESSVLLSMAFDRFVAICHPLhYVSILtNTVIGRIGLVSLGRSVALIFPLPFmLKRFPYCGSPVLSHSYCLHQEV 189
gi 47578045  104 HTFSIMESSVLLTMAFDRVVAISRPLhYATILtNPRVASLGVVILVRSIGLHIPAPImLKKLPYCQKHHLSHSYCLHPDV 183
gi 47578039  107 HTFSVIESAILLAMAFDRCVAIREPLrYATILtTRRIGAIGLAVVVRSAALHLPLPVlLGRLAFQPVSALSHSYCVHPDV 186
gi 47577375  106 HAFTYVESGVLLAMAFDRFIAIRDPLhYATILpHSAVAKVGAAVLVRAILLNLPGPIlLRRLIFPQISTLSHCYCLHCDL 185
gi 47578017  107 HTFQVLESAIILAMAFDRYMAISRPLhYHSILtDTVISRIGLSIVVRTLVVQVPLPIlLRRLYFCHSNVLSHSYRLHPDI 186
gi 38372710  113 HVFSVMESSVLLAMSIDRALAICRPLhYPALLtNGVISKISLAISFRCLGLHLPLPFlLAYMPYCLPQVLTHSYCLHPDV 192
gi 530650922 107 HTFSVMESSVLLAMAFDRFVAIRHPLrYASTLtSGRIGNIGLAIIIRGSGLHIPAVIlLKRLPYSKNQPLSYSYCLHPDV 186
gi 557317898 107 HTFTDIELAVILAMAFDRYVAISSPLwYASLLtNAFITKICLAIVVRTIIIQVPMPIlLTRLHFNVSNQLAHPYCLHPDI 186
gi 514795738 114 HSFTDIESATILALAFDRYMAICHPLrYSSILtNSVITKICVAIVIRTILFQFPLPIlLTQLCFSRASKLTHPYCLHPDI 193
gi 390470096 107 HLFTVSEASVLSVMAFDRYVAICNPLrYSTILtSSRVIKTGVFLTSKNILLIITLPFlLQWLKYCHQNLLSHSYCLHQDV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 38372712  190 MKLACADmkaNSIYGMFVIVSTVGIDSLLILFSYALILRTVLSIasrAERFKALNTCVSHICAVLLFYTPMIGLSVIHRF 269
gi 47578045  184 MKLACTDtqiNSAYGLFVVLSTLGVDSLLIVLSYGLILHTVLSIaskTERLKALNTCVSHICSVLLFYTPMIGLSMIHRF 263
gi 47578039  187 LRLSCSStvvNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIasnAERLKAFNTCISHICAVLLFYTPLVSLSMIHRF 266
gi 47577375  186 VGLACSDtriNSLVGLVSILLSLGLDSSLIMLSYVLILRTVLGIaspGERLKALNTCVSHLCIVLIFYLPKLGLSVLHRV 265
gi 47578017  187 IKLSCSStsvNSIFGLFVVLSTVGLDFLLILLSYVLILKTVLCMashSGRLKALNTCISHLCAVVLFFTPMICLSMLHRF 266
gi 38372710  193 ARLACPEa-wGAAYSLFVVLSAMGLDPLLIFFSYGLIGKVLQGVesrEDRWKAGQTCAAHLSAVLLFYIPMILLALINHP 271
gi 530650922 187 MKMACADttpSSFYGLFIVLSSLGLDSVLIVLSYIMIFKTVQSItswQERLKALNTCVSHICATLLFYTPLISLSMIHRF 266
gi 557317898 187 IKRAHSDtrvNSIYGLFVLLSTLGLDLLSVLFSYILILKTVLSIashHQRLKALNTCVSHVCAVLLFFTPMICLSMVHRF 266
gi 514795738 194 IKHADSDtkiNSACGLFVLLSTLGLDLLFVLLSYLLILKTVLNLatwREHLKALNNCISHVCAVLLFFIPMICLSMMHQF 273
gi 390470096 187 MKLACSDn-tVNVVYGLCAALSTMLDLVFIIFSYVMILKTVLGIatpREQFKALNTCISHICAVLIFYVPMLSAAMLHRF 265
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1              ## ###  #  ##                 
gi 38372712  270 Gkq-aPHLVQVVMGFMYLLFPPVMNPIVYSVKTKQI 304
gi 47578045  264 Gkw-aSPCSRVLLSYLHFLTPPVLNPVVYTIKTKQI 298
gi 47578039  267 GrkklPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
gi 47577375  266 Ekh-sYPALAVLMANLHFLVPPFMNPVVYCIKSKQI 300
gi 47578017  267 Gpr-lPSHVYVTLANMHFLIPPVMNPIVYVVKTKQI 301
gi 38372710  272 Elp-iTQHTHTLLSYVHFLLPPLINPILYSVKMKEI 306
gi 530650922 267 Enk-aLPQSQILLSYLHLLLPPVLNPIVYSIKTKEL 301
gi 557317898 267 Gkd-vSPQVYVLLANLDFLVPPMLNPIIYSVRTRAI 301
gi 514795738 274 Gkh-mSPQVYTFTANLHFLAPPILNPIVYSMKTKVI 308
gi 390470096 266 Ard-vPPIIHILMADIFLLVPPLMNPIVYCVKTHQI 300

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