Conserved Protein Domain Family
7tmA_OR56-like

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cd15223: 7tmA_OR56-like 
olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320351
View PSSM: cd15223
Aligned: 14 rows
Threshold Bit Score: 368.158
Threshold Setting Gi: 229462916
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372699   34 HWLSLPLALLYLLALSANILILIIINKEAALHqPMYYFLGILAMADIGLATTIMPKILAILWFNaKTISLleCFAQMYAI 113
gi 38372812   29 HWLSLPLSLLFLLAVGANTTLLMTIWLEASLHqPLYYLLSLLSLLDIVLCLTVIPKVLTIFWFDlRPISFpaCFLQMYIM 108
gi 47577305   29 ALLMLPFLSLYLVILFTNALVIHTVASQRSLHqPMYLLIALLLAINICAATTVLPAMLFSFSTSfNRISLprCLGQMFCI 108
gi 557027757  27 LHFSILFCVLYLLAVTCNLALLCIIKADHNLHePMYIFLSILATVDLVLSSTTFPKLLAILWFGdSTITFegCFVQMSFA 106
gi 557027765  27 PWLSIPFCTLYVLALVCNSSLLLIITVEHGLHePMYFCLCVLASADLVLCTSILPKLLAIFWFDaKAITFggCFTQMAVV 106
gi 573879623  27 RFLSIPFIIMLIVAVIGNSTIIFIIKTGSGLHsPMYVLIGAIAIVDLSLPMLFIPKMLLNFLFDlNEISLlgCLVQMFFI 106
gi 641993841  28 RLLSLPFLTTYILVLVGNSLLIYVIRIMESLHsPMYILICGLAAVDIVVATVIIPNMLLSFLFDwNDISLasCLTQMFFT 107
gi 597749860  28 RLLFLPFFLSYLVILIGNSLILFVIKNTKSLHnPMYILVSALALVDIAVPTAIIPAMLPSFLFDlNEITLvgCLMQMFFI 107
gi 573879627  27 RFLSIPFLIMFVVATVGNSVLISVLKRGSGLQsPMYILIGALAVVDLTLPVLFVPKMLLNFLFDwNSISLpgCLVQMFFI 106
gi 558155780  30 ALLFIPFFCLYLVNVGANCTVIYTIWVERSLHsPMYLLISLLSAMGLCSTSAILPQMLLGFLAHsSRLSLpgCLAQMFFI 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372699  114 HCFVAMESSTFVCMAIDRYVAICRPLrYPSIITESFVFKANGFMALRNSLCLISVPLlaAQRHYCSQNQIEHCLCSNLGV 193
gi 38372812  109 NCFLAMESCTFMVMAYDRYVAICHPLrYPSIITDHFVVKAAMFILTRNVLMTLPIPIlsAQLRYCGRNVIENCICANMSV 188
gi 47577305  109 YFLVSMDCNILLVMALDRYVAICYPLrYPEIVTGQLLAGLVVVAVTRSTCIVAPVVVlaSRVRFCRSDVIHHFACEHMAL 188
gi 557027757 107 HFFTAMESTILVVMAFDRYVAICKPLhYTAIFTNSFIVKLGTVSVLRSAVLSLPQYMysSQLSFCSSNVIPHYYCDHTTT 186
gi 557027765 107 HFFTATESAILVVMAYDRYVAICKPLlYSTIITNGFIMKLCAVGLVRSAVLLLPQYMfsSQLSYCASNEISHCFCDHSSI 186
gi 573879623 107 HFVSSFESTILLVMALDRYVAICNPLrYNDYINKSTFLKLSVAALIRSGILISLIVIlaGSLSYCLSNVIEHCYCEHMAL 186
gi 641993841 108 HFLSSVESTILLAMALDRYVAICYPLhYARILNPATFLRLLLFTVIRSGSIMFVLVAlaGSLSFCGSNVINHCYCDHMAL 187
gi 597749860 108 HFLSSVESTILLAMALDRLVAICNPLrYTAIMNTSTFLKLLLFTLIRSGIIMSTLVGlaSPLSFCGSNIIHHCYCDHMAL 187
gi 573879627 107 HMLASLESAILLVMAIDRYVAICNPLrYNDYINMSTFLKVSIAVVIRNGLFISLIVIqaGSLSFCLSNVIEHCYCEHMVL 186
gi 558155780 110 YLLIIMDSSVLLLMALDRYVAICKPLrYVDIMSKRLLAGMVLAALIRGISVACLMVVlaSRLPFCQSNVIQHFACEHMAL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 38372699  194 TSLSCDDrriNSINQVLLAWTLMGSDLGLIILSYALILYSVLKLnspEAASKALSTCTSHLILILFFYTVIIVISITRST 273
gi 38372812  189 SRLSCDDvtiNHLYQFAGGWTLLGSDLILIFLSYTFILRAVLRLkaeGAVAKALSTCGSHFMLILFFSTILLVFVLTHVA 268
gi 47577305  189 MKLSCGDtslNKTVGLIIRTFNRVLDMLLLGASYSRIIHAAFRIssgGARSKALNTCGSHLLVIFTVYSSTMSSSIVYRV 268
gi 557027757 187 LSIACADitiNKIFSILLTMLISGTDITLIFFSYLLILRAVFKLgsaRARWKTFSTCVSHFCVILYFYTAVLFSIFTKRF 266
gi 557027765 187 LRLACTDtatNSFVGLIVSLFMVVTDIIFIMISYFLILRAVIKLastKARQKAFNTCASHFYVILYFYTALVFSILTKRF 266
gi 573879623 187 VGLACESttkNSIMGLLVVFCIPGLDLLFIFFSYLKIFSVVFKAasgKSCHKAMHTCGTHLIVILVSYTLAMCSFIAYRF 266
gi 641993841 188 VSLACGNtdkNNAIGLAVIICFVGIDICVIVFSYVKILNVVLRRaagEDRWKAFHTCGTHLIVIMCFYLIGTVTFLSRNL 267
gi 597749860 188 VSLACNStarNSAMGVAVIVCFVGIDISVIFLSYVKILYVVLRAaagEQRSKALNTCGTHLIVMMCFYFVGSVTFLSRNL 267
gi 573879627 187 VNLACGNttqNSIIGLLAIICILGSDLMFICYSYCTIFCTVLKAasgKSRQKAVHTCGTHLIVILLSYSLAIGSFLVYRF 266
gi 558155780 190 VSLACSStshNSILSMVMGSVIIVFDTFCILASYTSIIHTALQIasgSLRRKAFHTCGTQLLVMFFMYSSFLSSSIVYRA 269
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1             ## ###  #  ##                     
gi 38372699  274 Gm-rVPLIPVLLNVLHNVIPPALNPMVYALKNKELRQGL 311
gi 38372812  269 KkkvSPDVPVLLNVLHHVIPAALNPIIYGVRTQEIKQGM 307
gi 47577305  269 ArtaSQDVHNLLSAFYLLLPCLVNPIIYGARTKEIRQHL 307
gi 557027757 267 Gn-iPSEYNILVASSYVLIPPALNPIIYGIRTKEIRQAF 304
gi 557027765 267 GktiPSFAHILIASSYILVPPALNPLIYGVRTKEIRQGV 305
gi 573879623 267 GksvPPDVHVLISVIYVIFPCCFNPVIYGVRTKEIRDQI 305
gi 641993841 268 NiqiPTDINTFLGVMYIVLPASVNPIIYGVRTKEIRNRI 306
gi 597749860 268 SipiPVDVNTFLGITYIVFPACINPIIYGVRTKEIRNAL 306
gi 573879627 267 RdvvSPDVHNLMSVMYVIFPSCFNPVIYGVRTKEIREEI 305
gi 558155780 270 GqavSQDVHNLLSAIYLLLPSTLNPIIYGVRTKEIKQRV 308

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