Conserved Protein Domain Family
7tmA_OR6B-like

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cd15224: 7tmA_OR6B-like 
olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320352
View PSSM: cd15224
Aligned: 20 rows
Threshold Bit Score: 416.684
Threshold Setting Gi: 301609598
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##               ####
gi 14423779   25 AAMFLIFLVAYILTVAENVIIILLVLQNRPlhkPMYFFLANLSFLETWYISVTVPKLLFSFws----vnNSISFtlCMIQ 100
gi 85700382   29 DALFAVFLTLYLLTLLENTLIIYLICSHKElhkPMYFFLGNLSCLEMCYVSVTMPTLLMGLwn----glYHIPFiaCMTQ 104
gi 38372783   30 LLFFSIFLATYLLTLLENLLIILAIHSDGQlhkPMYFFLSHLSFLEMWYVTVISPKMLVDFls----hdKSISFngCMTQ 105
gi 47577027   26 GLLFGLFLIIYVVTVLENLVIVGTISASRQlhiPMYFFLANLSVLETLYTTVTVPKLLAGLla----gaKAISFsgCLTQ 101
gi 38372784   25 LLLFVLFFAIYLLTLLENALIVFTIWLAPSlhrPMYFFLGHLSFLELWYINVTIPRLLAAFlt----qdGRVSYvgCMTQ 100
gi 51338748   26 VLLFALLLLAYVLVLTENTLIIMAIRNHSTlhkPMYFFLANMSFLEIWYVTVTIPKMLAGFvgskqdhgQLISFegCMTQ 105
gi 564235500  52 VLLFLIFIIIYVLTLAENMVIIVTVRMSIHlqtPMYFFLSNLSFLEMWYITVTMPKMLLSLlt----ssQNISFvgCMTQ 127
gi 557322140  27 VLLFSVFLITYMLVVTENTVIILTVHRNRHlhtPMYFFLSNLSFLEIWYITVTLPKTMLNFlm----enKHISFvgCMMQ 102
gi 527245806  28 ILFFPIFLIAYLLVLAENMIIILTVWTNYNlhtPMYFFLSNLSFLEIWYVTVTVPKTILSFvs----vtKGISFmgCMTQ 103
gi 449279688  31 VLLFSAVLLAYLLTVLENFLIILIIRTNHSlqkPMYFFLGNLSFLEICYVSVIEPKMLIDFls----qdKNISFhgCMTQ 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ##  #                                            # #####                     
gi 14423779  101 LYFFIALMCTECVLLAAMAYDRYVAICRPlhYPTIMsHGLCFRLALGSWAIGFGISLAKiyfiscLSFCGPnVINHFFCD 180
gi 85700382  105 LFFFIVLVGTECILLASMAYDRYVAICRPlhYPVLMrPQVCLGLAMISWLGGLLVSMIKttciatLSYCGPnVLNHFFCD 184
gi 38372783  106 LYFFVTFVCTEYILLAIMAFDRYVAICNPlrYPVIMtNQLCGTLAGGCWFCGLMTAMIKmvfiaqLHYCGMpQINHYFCD 185
gi 47577027  102 LFLFLSLGSSECFLLSTMACDRYLAICRPlhYPAIMdSKLCLHLALSAWLGGFLASFVStalisrLSFCGSnALNHFFCD 181
gi 38372784  101 LYFFIALACTECVLLAVMAYDRYLAICGPllYPSLMpSSLATRLAAASWGSGFFSSMMKllfisqLSYCGPnIINHFFCD 180
gi 51338748  106 LYFFLGLGCTECVLLAVMAYDRYMAICYPlhYPVIVsGRLCVQMAAGSWAGGFGISMVKvflisgLSYCGPnIINHFFCD 185
gi 564235500 128 LYFFIALACTECVLLAVMAYDRYVAICSPlrYPAIMtHELCFRLVAGSWMGGFTSSMLKvtfisrLTFCGS-VINHFFCD 206
gi 557322140 103 LYFFLALGCTVCVLLAVMPYDHYVAICNPlrYPAIMsRALCTHLAAGSWISGFFISMWKvllisqLTYCGPnIINHFFCD 182
gi 527245806 104 LYFFLSLGNTECLILAVMAYDRYVAICKPfhYSTIMrHTVCVYLTTGSWLTGFLISGCKvffisgLTYCGPnTINHFFCD 183
gi 449279688 107 LYFFVTFVCTEYILLAVMAYDRFLAICKPlqYSLIMnHQFCAQLTAACWMCGLITSSIKlsfiaqLSFCGVdKINHYFCD 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #  ### ### ##                                            #  ## ## 
gi 14423779  181 ISPVLNLSCTDmsiTELVDFILALVIFLFPLFITVLSYGCILATILcm--pTGKQKAFSTCASHLVVVTIFYSAIIFMYA 258
gi 85700382  185 VSPLLNLSCTHvalTELVDFISAIVILWGCFLTTMASYVAIGRAVLrmpstTARYKAFSTCASHLVVVGIFYSVTIFIYA 264
gi 38372783  186 ISPLLNVSCEDasqAEMVDFFLALMVIAIPLCVVVASYAAILATILripsaQGRQKAFSTCASHLTVVILFYSMTLFTYA 265
gi 47577027  182 VSPLLQLSCTDttaIEMLDFVAALAVLATSLIVTSVSYVHIVATVLripggAGRRRAFSTCASHLVVVLIFYTTTTFMYA 261
gi 38372784  181 ISPLLNLTCSDkeqAELVDFLLALVMILLPLLAVVSSYTAIIAAILriptsRGRHKAFSTCAAHLAVVVIYYSSTLFTYA 260
gi 51338748  186 VSPLLNLSCTDmstAELTDFILAIFILLGPLSVTGASYVAITGAVMhipsaAGRYKAFSTCASHLTVVIIFYAASIFIYA 265
gi 564235500 207 ISPLLNLACTDmslAELVDFILALIMILMPLLVVVASYLCIAAAVAqiptaQGRRKAFSTCASHLAVVVIFYSTTLFTYA 286
gi 557322140 183 VSPLLTLACTDmslAELTDFILVLFILLIPLCVTIFSYIYIISTIVhipsaHGRQKAFSTCASHLTVVIIFYAASIFIYA 262
gi 527245806 184 VSPLLNLACTDlerAALMDFVAALFILLIPLSVVILSYTYIIFTVLhissvQDRQKAFSTCASHLIVVTVFYATSIFIYV 263
gi 449279688 187 ISPLLNISCSDsslAELVDFVLALIVIMVPLCTVVTSYICIIFTMLkipssRGRQKAFSTCSSHLTVVILFYSTTLFTYA 266
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1         #     ## ###  #  ##              
gi 14423779  259 RPrvihAFNMNKIISIFYAIVTPSLNPFIYCLRN 292
gi 85700382  265 RPkrieAMDLNKVLSVIYTVVTPMCNPVIYCLRN 298
gi 38372783  266 RPklmyAYNSNKVVSVLYTVIVPLLNPIIYCLRN 299
gi 47577027  262 RPhaisSFDLNKLVSVIYSVVTPLLNPIIYCLRN 295
gi 38372784  261 RPramyTFNHNKIISVLYTIIVPFFNPAIYCLRN 294
gi 51338748  266 RPkalsAFDTNKLVSVLYAVIVPLLNPIIYCLRN 299
gi 564235500 287 RPramlAFDSNKLVSVLYTIVVPLFNPIIYCLRN 320
gi 557322140 263 RPkaisSLNSNKLISVLYTVIVPLFNPIIYCLRN 296
gi 527245806 264 RPktlpVNDTNKIVSAFYAVVVPLFNPIIYCLRN 297
gi 449279688 267 HPkvmyTYHANKLVSVLYTVVVPLLNPLIYCLRN 300

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