Conserved Protein Domain Family
7tmA_OR10A-like

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cd15225: 7tmA_OR10A-like 
olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320353
View PSSM: cd15225
Aligned: 147 rows
Threshold Bit Score: 347.905
Threshold Setting Gi: 281185475
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 296439244  26 ALLFLLFLTIYLVTLMGNVLIILVTIADSALQsPMYFFLRNLSFLEIGFNLVIVPKMLGTLIiqDTTISFlGCATQMYFF 105
gi 564242033  25 KLLFVVFLFLYLVTLTTNATIMTIIRIDHTLHtPMYIFLCVLSFSETCYTFVIVPKMLVDLLaeNKTISFlGCAVQMYFF 104
gi 557325398  25 VGLFVVLLLVYLVTLAGNTMIMMVIQVDWSLHtPMYFFLGALSSSEICYTFTIIPKMLLDLVggNRTISFlGCAVQMYFS 104
gi 74762319   25 QLLFVIFLLLYLFTLGTNAIIISTIVLDRALHiPMYFFLAILSCSEICYTFIIVPKMLVDLLsqKKTISFlGCAIQMFSF 104
gi 564257180  25 LLLFPIFFLAYIVILISNISIMTAITVTWSLHtPMYFFLFALSFSELCSTFVIIPKTVVNLLveKKTISViGCATQMFGG 104
gi 14423769   25 LMLFLLFLLMYLFTLLGNLLIMATVWSERSLHtPMYLFLCVLSVSEILYTVAIIPRMLADLLstQRSIAFlACASQMFFS 104
gi 564234114  25 GVLFVVFLLMYLMTLAGNLAIMAVIQIDRHLHtPMYLFLGVLSFSETCYTFVIIPKTLVDLTaeSTTISFpGCVAQMFFF 104
gi 602668247  25 TLLFLIFSLTYGTILAFNITIMSVILLDRTLHcPMYFLLFALSVSETCTTFVTIPKLLMTLWtgRQSISLvGCATQMFCF 104
gi 47576933   23 NLLFVVIFLSHMTILIANASIMVAIKLNHNLHtPMYFFLFALSFSETCTTMVILPRILVDLLseSKVISLpECATQMFFF 102
gi 620988322  25 RLLFGLFLPIYLVTLEANAVIVTTIVLDRRLHvPMYFFLATLSCSETLYTLVIIPKALVDLLaqHRAITItACAFQMGSF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 296439244 106 FFFGAAECCLLATMAYDRYVAICDPLHYPVIMgHISCAQLAAASWFSGFSVATVQTTwIFSFPFCGPnRVNHFFCDSPPV 185
gi 564242033 105 LFLGCSHSFLLAAMGYDRYVAICNPLHYAIIMsKKVCAQLVAACCFSGFLVAQVVTTlVFRLPFRFPsKLNHFFCDISPV 184
gi 557325398 105 FLFGFTHSFLLTVMGYDRYVAICNPLRYNVFMnTRICVQMVAASWAGGCLIGLVVTVtVFHLPFCGPnKISHFFCHMPPL 184
gi 74762319  105 LFLGCSHSFLLAVMGYDRYIAICNPLRYSVLMgHGVCMGLVAAACACGFTVAQIITSlVFHLPFYSSnQLHHFFCDIAPV 184
gi 564257180 105 FGFGAINCFLLTVMAYDRYVAICHPLQYSAMMnRKVCIQLVTISCVTGFLISLTINSlVFSLPLCGPrTIRHFFCDVKPV 184
gi 14423769  105 FSFGFTHSFLLTVMGYDRYVAICHPLRYNVLMsPRGCACLVGCSWAGGSVMGMVVTSaIFQLTFCGShEIQHFLCHVPPL 184
gi 564234114 105 LGLGGTNCIILTVMGYDRYLAICHPLRYGSLMsSHIFVKLMAGSWISGFLLSLFETTlIFWSPFCGSnIINHFFCHMRPV 184
gi 602668247 105 FSLGANNCFLLVAMSYDRYAAICYPLQYQVLMeKRVCIKLVAASCVTGCFISLVICIlIFRLPFCGPnRIQHFFCDISPV 184
gi 47576933  103 FGLAGNNCFIMAAMSYDRYTAIHSPLHYHIFMtQKVCFQLIMASCVIGFLCSLSITFtIFNLSFCDSnTIQHFFCDISPL 182
gi 620988322 105 LFLGCSHSFLLAAMGFDRYVAICRPLNYARLMtRGVCMVLVAAASSCGSAVSLVVTFlIFGSPGPSSgRLQHFFCDIPPV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                             #  ## ##  #
gi 296439244 186 IALVCADts-vFELEALTATVLFILFPFLLILGSYVRILSTIFRmp-saEGKHQAFSTCSAHLLVVSLFYSTAILTYFRP 263
gi 564242033 185 LKLAFTHmh-lNDVIIFLLGIFALMLPLLLILVSYIYILIAILHip-stTGRRKTFSTCAAHLTVVVVHYGCASFIYLRP 262
gi 557325398 185 IELTCTDsn-tLGTLVGTFCMAGLLGCFLFILLSYAFILSTILCip-saVGQHKAFSTCASHLTVVIVHYGCASIIYLKH 262
gi 74762319  185 LKLASHHnh-fSQIVIFMLCTLVLAIPLLLILVSYVHILSAILQfp-stLGRCKAFSTCVSHLIIVTVHYGCASFIYLRP 262
gi 564257180 185 LRLACGAiy-lAEIVVVSLCAFVIVGTFTVIIISYIYILSAILKih-svAGRCKTFSTCASHLTVVVTHYGCASFVYLRP 262
gi 14423769  185 LKLACGNnvpaVALGVGLVCIMALLGCFLLILLSYAFIVADILKip-saEGRNKAFSTCASHLIVVIVHYGFASVIYLKP 263
gi 564234114 185 LRLACTDsn-tTEVAISMMSMLGLSGSFLFIVLTYLLILGTILRlpsasGEREKAFSTCAAHLTVVVMHFGFASIIYLKP 263
gi 602668247 185 LSLTCIDty-lTNLGIVLLCALVLLGTVLLISISYFYIISAILRic-ssLRRRKAFSTCASHLTVVITHFSCACFVYLRP 262
gi 47576933  183 VYLACDYta-hHAMIIFMLSAFVLVGSFVLIMISYIFIVFLVVKmp-saQGRHKAFSTCSSHLTVVTMHYGFACFVYLIP 260
gi 620988322 185 LKGDLASwlptARXVILALGALVLVIPLFLIAASYAHIVATILRip-ssRGRVKPFSTCASHLIVVTIHYTCASFIYLRP 263
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1             ## ###  #  ##                     
gi 296439244 264 qssaSSESKKLLSLSSTVVTPMLNPIIYSSRNKEVKAAL 302
gi 564242033 263 kssySSDQDTLISVTYTILTPLLNPMIYSLRNKEVKMAL 301
gi 557325398 263 ksprSSDAGTLIDLTYTVITPFLSPIIFSLRNKELKNAF 301
gi 74762319  263 qsnySSSQDALISVSYTIITPLFNPMIYSLRNKEFKSAL 301
gi 564257180 263 ksssSLNEDTLISVGYLLLTPCLNPMIYSLRNKEVKFAL 301
gi 14423769  264 kgphSQEGDTLMATTYAVLTPFLSPIIFSLRNKELKVAM 302
gi 564234114 264 sprgTLEEDILMSVPYTILTPFLSPMIFTLRNKEIKSAL 302
gi 602668247 263 kaasSLDQDTLISTVYVFLTPLLNPLIYTLRNKEVKLSI 301
gi 47576933  261 knsgSFHEDMLMAVTYTVLTPLLNPIVYSLRNKEMQTAL 299
gi 620988322 264 gagdSSGRDALVSVTYTIVTPLLNPVIYSLRNRDFKAAL 302

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