Conserved Protein Domain Family
7tmA_OR4-like

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cd15226: 7tmA_OR4-like 
olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320354
View PSSM: cd15226
Aligned: 38 rows
Threshold Bit Score: 379.625
Threshold Setting Gi: 327278308
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372682   23 SVCFVVFLPVYLATVVGNGLIVLTVSISKSLdsPMYFFLSCLSLVEISYSSTIAPKFIIDLLakIKTISLeGCLTQIFFF 102
gi 38372659   25 LLLFVFSLLFYFASMMGNLVIVFTVTMDAHLhsPMYFLLANLSIIDMAFCSITAPKMICDIFkkHKAISFrGCITQIFFS 104
gi 47577035   25 IFLFFFSCLFYVSSLTGNFIIVVTVTSDPYLhsPMYFLLANLSVIDLIFCSIAAPKMICDLFrkQKVISFgGCISQVFFS 104
gi 38372660   25 LLLFLFFSVFYVSSLMGNLLIVLTVTSDPRLqsPMYFLLANLSIINLVFCSSTAPKMIYDLFrkHKTISFgGCVVQIFFI 104
gi 47577169   25 HFFLAFSMVLYVAIVLGNTLVVFTLAFDQHLhsPMYFLLGNLSFIDLCLSTLTVPKMISDLSsgHNTISFhSCVFQIFVL 104
gi 74762307   25 LLLLVFSSVLYVASITGNILIVFSVTTDPHLhsPMYFLLASLSFIDLGACSVTSPKMIYDLFrkRKVISFgGCIAQIFFI 104
gi 47577115   25 IFFGLLFSLFYVGILFGNLFIVFIVIFDSHLhsPMYILLANLSLIDLGLSSTTIPRTISDIFtgCKVISFhSCMIQMFFI 104
gi 47577147   25 VFLMVTFSMLYIGIILGNLFIVILVIADSHLhsPMYFLLANLSLNDVWVSSTTVPKMISDLLkeHKVISFhNCMSQICFI 104
gi 620982122   8 HLLFVLFSVFYMAIVLGNSLIVLTVVADPRLhsPMYFLLANLSFFDICVSSTVTPKMIYDTLrdSKIISFgGCFAQMIFI 87
gi 505829001  35 LFLFFFPCVFHVSSMMRNFVIVITVTFDPYL--HSYFLLANLSSIDPIFCSIATPKTICDDFr-KQKXSFgHCIAQIFFS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372682  103 HFFGVAEILLIVVMAYDCYVAICKPLhYMNIIsRQLCHLLVAGSWLGGFCHSIIQILVIiqLPFCGPNVIDHYFCDLQPL 182
gi 38372659  105 HALGGTEMVLLIAMAFDRYMAICKPLhYLTIMsPRMCLYFLATSSIIGLIHSLVQLVFVvdLPFCGPNIFDSFYCDLPRL 184
gi 47577035  105 HAVGGTEMVLLIAMAFDRYVAICKPLhYLSIMsPRMCLLILVAAWIIGLIHSSTQLAFVinLPFCGPNILDSFYCDIPRL 184
gi 38372660  105 HAVGGTEMVLLIAMAFDRYVAICKPLhYLTIMnPQRCILFLVISWIIGIIHSVIQLAFVvdLLFCGPNELDSFFCDLPRF 184
gi 47577169  105 HVLGASEMVLLVAMAWDRYVAICKPLhYLTIMnPRMCLLLLSGAWIIGFLHSVAQLGFVvhLRFCGPNEIDSFYCDLPRF 184
gi 74762307  105 HVVGGVEMVLLIAMAFDRYVALCKPLhYLTIMsPRMCLSFLAVAWTLGVSHSLFQLAFLvnLAFCGPNVLDSFYCDLPRL 184
gi 47577115  105 HVMGGVEMVLLIAMAYDRYIAICKPLhYLMIMnPKTCIILVVAAWVIGMIHAVSQFMFVinLPFCAPYNVGSFYCDFPRV 184
gi 47577147  105 HIMGGVEMVLLIAMAFDRYIAICKPLrYLSIMsPRICISFVIAGWVTGVIHALSQFSFVvnLPFCGPNKVDSFYCDFPRI 184
gi 620982122  88 HIVGGSEMVLLVAMAYDRYVAICRPLhYVAIVtLRMCIWIVVAAWIIGLIHAMSQAAFVvnLPFCGPNEVDSFFCDFPRI 167
gi 505829001 112 HAVGGSEMVLLIAMAFDRXVATCKPFhYLTIMxLCMYTLIFEVAWTIGVIHSLTSIAFLviLPFCGSNILDSFFXDTPWQ 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                           #  ## ##  #   
gi 38372682  183 FKLACtdtfmEGVIVLANSGLFSVFSFLILVSSYIVILVNLrnhsaEGRHKALSTCASHITVVILFFGPAIFLYMRPssT 262
gi 38372659  185 LRLACtntqeLEFMVTVNSGLISVGSFVLLVISYIFILFTVwkhssGGLAKALSTLSAHVTVVILFFGPLMFFYTWPspT 264
gi 47577035  185 IKLACtdtykLEFMIAANSGFISLIAFFLLIISYVFLLNTVqkqssGCSSKALSTLLAHIIVVVLFFGPLIFFYVWPapS 264
gi 38372660  185 IKLACietytLGFMVTANSGFISLASFLILIISYIFILVTVqkkssGGIFKAFSMLSAHVIVVVLVFGPLIFFYIFPfpT 264
gi 47577169  185 IKLACmdnyrMEFMVAANSGIISIGTFFLLIISYIVILLTVrkhssGDLSKALSTLSAHISVVVLFFGPCIFVYMWPfpT 264
gi 74762307  185 LRLACtdtyrLQFMVTVNSGFICVGTFFILLISYVFILFTVwkhssGGSSKALSTLSAHSTVVLLFFGPPMFVYTRPhpN 264
gi 47577115  185 IKLACmdtykLEFVVSANSGFISMCTFFFLITSYIFILVNVrqhssTDLSKAFFTLSAHITVVVLFFIPCMFLYVWPfpT 264
gi 47577147  185 IQLACtdgdkFEFVVAANSGFMSMGTFFLLLLSYVFILVTVwqrssGDLSKALVTLSAHITVVVLFFTPCMFLYVWPfpT 264
gi 620982122 168 IQLACtdtywLELMVTANSGFISMGTFLLLIFSYVFILVSVrkrssVGLSKAFSTLSAHISVVVLFFGPCIFVYIWPfpK 247
gi 505829001 192 MKLPCtntykLQLMVTSNSRFISLGAFFMLILSYIFILVTVqkhlsDSFSKALSTLXAHIILVIYFGPLIFFYVCFLlqH 271
                        250       260
                 ....*....|....*....|....*..
Feature 1        ## ###  #  ##              
gi 38372682  263 FTEDKLVAVFYTVITPMLNPIIYTLRN 289
gi 38372659  265 SHLDKYLAIFDAFITPFLNPVIYTFRN 291
gi 47577035  265 THVDKFLAIFDAVLTPFLNPVIYTLRN 291
gi 38372660  265 SHLDKFLAIFDAVITPVLNPVIYTFRN 291
gi 47577169  265 VPVDKFLAILDFMITPILNPAIYTLRN 291
gi 74762307  265 SQMDKFLAIFDAVLTPFLNPVVYTFRN 291
gi 47577115  265 KSLDNFFAIVDFVLTPILNPTIYTLRN 291
gi 47577147  265 SSIDKYLFIADFAITPALNPVIYTLRN 291
gi 620982122 248 LPVDKTLAVFDAVITPFLNPIIYTFRN 274
gi 505829001 272 IXTDKFLATFDTVLTPSPNPFIYTLRN 298

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