Conserved Protein Domain Family
7tmA_OR14-like

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cd15227: 7tmA_OR14-like 
olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320355
View PSSM: cd15227
Aligned: 135 rows
Threshold Bit Score: 364.082
Threshold Setting Gi: 557325400
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 206558302  23 ILYGVLFLLIYLAALMSNLLIITLITLDVKLqtPMYFFLKNLSFLDVFLVSVPIPKFIVNNlthnNSISIlGCAFQLLLM 102
gi 602673863  23 ILYFTLFLVIYLAALIANLLIISAVSFHRHLhtPMYFFLVNLSVVDLGSISVTIPKAMMNSflntREISYaGCIAQVFSL 102
gi 602673543  23 IVHFVTFLAIYLVALMGNFLIITVISLNTHLhtPMYFFLVNLSIADLGAISVTIPKTMTHT----RTISYiGCAAQVFFL 98
gi 602643128  23 MVHILIFLIIYLMALIENLIIITVIVCSHQLhsPMYFFLANLSFQDLGSISVTVPKSMLNSlmntETISYpGCLSQVFFF 102
gi 327279760  23 ILSFFVFLAFYLTALIGNLLIITVVAVDSHLhtPMYYLLFNLAMLDIGSISVMVPKAMAMSlkndRSITYaGCVAQVFFY 102
gi 602673859  18 TFYFLVFFVIYTASVIGNLLIIIIVILNIHLhtPMYFFLLNLSVIDLGYISVIIPKVMANSlrrtRIILFsHCAAQMFSS 97
gi 602673571  23 ILYFLALSIIYLTSLTGNFLVIVAVALNNTLhtPMYFFLANLSTIDLGYISVTIPKAIANLlmatWQISYpECVAQVFFF 102
gi 327279664  24 PFHFLAFLFIYLMAVIENLFIITVIIKSHHLhkPMYFFMANLAFQDLGSISVTVPKSMENSlkkiNTISYsGCICQVFFL 103
gi 602673573  23 ILYFVILFLIYLAAMVGNLLIIIVVVLDHHLqaPMYFFLVNLSVTDLGYISVTILKAMVNSlkktTRISYrGCVAQTFFL 102
gi 602677316  23 ILTFGGFLLIYLAALIGNLLMITVVTLNPHLqtPMYFFLVNLNIVDLSFISVTVPKAMANSvmntKRISYyGCMAQVFFF 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 206558302 103 TSFSAGEIFILTAMSYDRYVAICCPLNYEVIMnTGVCVLMASVSWAIGGLFGTAYTAgtFSMPFCGSSVIPQFFCDVPSL 182
gi 602673863 103 FFFLISDLFLLTAMAYDRYIAICDPLHYETIMdMNACLQLAAIAWITGLLYSALHTCs-TFAVTFCSNVLNQFFCEIPQL 181
gi 602673543  99 IFFMAVDVSLLTVMAYDRFVAICDPLHYVIVMsRASCVQMAVIVWVSGLLYGSVHVGg-TFSITFCSNVVNQFFCEIPQL 177
gi 602643128 103 VFFVMSHFFLLVVMAYDRYVAICNPLHYEMIMnKKTCIQMVTSAWMAGLFYTTLYTGn-LFMVKFCSRIINQFFCEIPQL 181
gi 327279760 103 IFFGASGYSVLTIMAHDRYVAICHPLHYERIMhKGACLQMVATGLIASLIYAILHTGc-TFANTFCSNIVNQFFCEIPQL 181
gi 602673859  98 VVFAASEILLLTVMAYDRFVAICHPLQYETIMdRSRCIQLASYAWMMGIVIATLHTSa-TFASPFCSNVIHQLFCEIPQL 176
gi 602673571 103 TLFGNSEFFLLTIMAYDRYVAICNPLQYESLLnKKACIQMVTSMWAVSLFYAVLHSSc-TFAITFCSNLINQFFCEIPSL 181
gi 327279664 104 LFFTISHFYLLGIMAYDRYIAICNPLKYETIMnKKACIHMAMSTWICGFGLSSLYTGs-LFTVSFCSNDVNQFFCEIPQL 182
gi 602673573 103 LLFGGSELFLLTMMAYDRYVAICNPLNYVKEMnRGMCVKMATSAWIFGLLDAVLNTAc-TFTITFCSNNINQFFCEIPQL 181
gi 602677316 103 FWAGTSEFLLLALMAYDRYVAICNPLNYVKEMnREACLKMATSAWIFGFFDASLNTAc-TFTVTFCFNKINQFFCEIPQL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 206558302 183 LRISCset-lmVIYAGIGVGACLSISCFICIVISYIYIFSTVLKIPttKGQSKAFSTCFPHLTVFTVFIITAYFVYLKPp 261
gi 602673863 182 LKVSCdns-ylIEVGVILLSACIVFACFGFIIVSYVQIFKSVLRIPssQGRNKAFSTCFPHLLVVSLFISTGSIAYLKPt 260
gi 602673543 178 LRLSCsnl-ylMEVGILVLGACLVFSCFVFITISYVQIFRAVMKIPsmKGRQKAFSTCLPHLIVVSLFICICAFAYLKPi 256
gi 602643128 182 LKISCsds-yfVEVWALIFGSCLAFIQFALIAFSYVQIFRAVFKIPstQGKQKAFSTCLPHLIVICLFVVSGTLAYLCPt 260
gi 327279760 182 IKLSCsgl-slMETGVLILSFSIALGCLIFIIRSYVQVFVVVLRIPssQGQKKALSTCVPHLTVVTMFVASGVLAYARSi 260
gi 602673859 177 LRLSCsdt-yhIEIGAIALTTVLYVACFVFIVISYTQIFKAVVRIPseQGRQKAFSTCLPHLIVLSMLYFFGMFAYLRPi 255
gi 602673571 182 LQLSCsds-yiLEDRMMSLAMLFVVGCFSFIIISYLKIFKAVLKIPsaKARKKATSTCFPHLFVLFLFFFTGGIAYLGPs 260
gi 327279664 183 LKISCsdt-ylIAFYVICAGSSISFIYISLIISSYIEIFRAVLKITstQRKPKAFSTCLPHLIVIVLYIISGSLVYLRPm 261
gi 602673573 182 LKLSClnssylAEIGALIFTVLICLSCFCFTVMSYVQIFRAVFTIPsvQGQKKAFATCLPHLLVLSLFYFTGMYTYLSSg 261
gi 602677316 182 LKLSCssssylVELGALVFTVLICVCCFSCTVVSYVYIFRAVFIIPsaQGKKKAVSTCLPHLAVLCLFYFTGVYACLGTt 261
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1            ## ###  #  ##              
gi 206558302 262 snsPSVIDRLLSVIYTVMPPVFNPVTYSLRN 292
gi 602673863 261 sdsPSDVDVVITVLYSVIPPLMNPIIYTMRN 291
gi 602673543 257 srpPSDFDLVAAVIYCSVPFMMNPIIYSIRN 287
gi 602643128 261 stsSSALDPFLSIFYCVIPPLMNPLIYSMRN 291
gi 327279760 261 a-dSSNLDTVLAMIYTIIPPMSNPFIYSVRN 290
gi 602673859 256 nriPSQMDLVATIGYCIVPPFMNPVIYSMRN 286
gi 602673571 261 stiSGKMGLVLSVMYSVIPPFMNPIIYSIRN 291
gi 327279664 262 srsLSTMDLVLSVFYCMLPPLMNPLIYSIRN 292
gi 602673573 262 fkfSSGLNVPLAMMYSVVPPFTNPIIYSMRN 292
gi 602677316 262 fraSSGLDLLLAVLYSMVPPFMNPIIYSMRN 292

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