Conserved Protein Domain Family
7tmA_OR10D-like

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cd15228: 7tmA_OR10D-like 
olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320356
View PSSM: cd15228
Aligned: 13 rows
Threshold Bit Score: 437.633
Threshold Setting Gi: 85700374
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##                   
gi 74760322   25 MTLFVLFLPFYACTLLGNVSILVAVMSSARlhtpMYFFLGNLSVFDMGFSSVTCPKMLLYLmg----------------- 87
gi 47576217   23 SMLFILFLVFYVFALLGNLLIFLTILASPNlhtpMYFFLGNLAVFDIFFPSVNSPKMMDSLvg----------------- 85
gi 47576257   23 TMLFVLFLSFYIFTLMGNLLILLAIISSSRlhtpMYFFLCKLSIFDIFFPSVSSPKMLFYLsg----------------- 85
gi 38372737   23 TALLFLFSSFYLCTLLGNVLILTAIISSTRlhtpMYFFLGNLSIFDLGFSSTTVPKMLFYLsg----------------- 85
gi 85700374   23 TLLFVVFLFIYFFTLLGNSLIFTAIISSSTlhtpMYFFLGLLSVFDMLFPSVTCPKMLFYLsv----------------- 85
gi 444518996  43 TVLFVVFLIFYLCTLLGNLLILVAVVSDARlhtpMYFFLCNLSVLDIGFSSVSTPKMLANLlv----------------- 105
gi 530651307  25 TILFITFLAFYLCTLLGNLLIFSAILADPRlhtpMYFFLCNLSVLDIGISSISIPKYLTMLwg----------------- 87
gi 558174710 201 TILFFTFLAFYLCTLLGNLLIFSAVLVDPRlhtpMYFFLCNLAVLDMGISSLSVPKLLASLwfqdkvislggcmaqvftg 280
gi 558190494  18 TVLFFTFLAFYLCTLVGNLLILSAILADPRlhtpMYFFLCNLAVLDIGISSISIPKLLSILwa----------------- 80
gi 558135497  23 NILFVTFLSIYLCTLLGNLLILAAILTDPRlhtpMYFFLCNLAMVDLGFSSISTPKFLAILwa----------------- 85
gi 558204115  25 TILFFSFLAFYLCTLMGNLLIVSAVLADPRlhtpMYFFLCNLAVMDIGFSSVSIPKLLASLwf----------------- 87
gi 641785334  32 TILFVTFLAFYLCTLLGNLLIFSAILADARlhtpMYFFLCNLSVLDIGFSSISTPKFLANLwa----------------- 94
gi 440900175  25 VVLFVVFFIFYACTLLGNLLILLAVVSDSClhtpMYFFLCNLSVLDIGFSSVSTPKMLANLlv----------------- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        ###### ##  #    
gi 74760322   88 ------------------------------------------------------lSRLISYk-dCVCQLFFFHFLGSIEC 112
gi 47576217   86 ------------------------------------------------------qSRTISYq-gCASQVFFYHTLGGTEC 110
gi 47576257   86 ------------------------------------------------------nSRAISYa-gCVSQLFFYHFLGCTEC 110
gi 38372737   86 ------------------------------------------------------nSHAISYa-gCVSQLFFYHFLGCTEC 110
gi 85700374   86 ------------------------------------------------------rSPAISYk-gCAAQLFFYHLLGSTEG 110
gi 444518996 106 ------------------------------------------------------rSQVISLg-gCMSQVFFYHFLGSTEC 130
gi 530651307  88 ------------------------------------------------------qSRVISLg-gCMSQVFFGHFLGSTEC 112
gi 558174710 281 hflgstecllytvmafdryvaichplrclhiilavldmgisslsvpkllaslwfqDKVISLg-gCMSQVFTAHFLGSTEC 359
gi 558190494  81 ------------------------------------------------------nSKTISLg-gCMAQLFFYHFLASTES 105
gi 558135497  86 ------------------------------------------------------kSKTISLg-gCMTQVFFLHFLGSSGS 110
gi 558204115  88 ------------------------------------------------------qNKVISLgggCMAQVFFFHLLGSTES 113
gi 641785334  95 ------------------------------------------------------kSRTISLg-gCMSQVFFWHFLGSTEC 119
gi 440900175  88 ------------------------------------------------------kSRVISLd-gCMSQVFFYHFLGCTES 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                # #####                                 
gi 74760322  113 FLFTVMAYDRFTAICYPlrYTVIMnPRICVALAVGTWLLGCIHSSILTSLtFTLPYCGPNEVDHFfCDIPALLPLACADt 192
gi 47576217  111 FLYTLMAYDRFVAICHPmrYTIIMnHRVCTCLTVGTWVGGFVHGSILTFLiFKLPYCGPNEVDSFfCDIPVVLSLACADt 190
gi 47576257  111 FLYTVMAYDRFVAICYPlrYSIIMsHRVCAILATGTSFFGCIQATFLTTLtFQLPYCGPNEVDYYfCDIPVMLKLACADt 190
gi 38372737  111 FLYTVMACDRFVAICFPlrYTVIMnHRVCFMLATGTWMIGCVHAMILTPLtFQLPYCGPNKVGYYfCDIPAVLPLACKDt 190
gi 85700374  111 CLYSVMAYDRYVAICHPlrYMLIMkPGVCVSLVIIAWLVGCLHATILTSLtFQLVYCASNQVDYFfCDLPAVLPLACTDs 190
gi 444518996 131 LLYTVMAYDRFAAICYPlrYTIIMnRRVCALLAAGTWFTSSFHATILTTLtFQLPYCGSNEVDYFfCDIFPVVKLACGNt 210
gi 530651307 113 LLYTVMAYDRYVAICHPlrYLPIMnRRVCALLAAGTWITSSFHATILTSLtFTLPYCGSNVVDYFfCDIFPVVKLACADt 192
gi 558174710 360 LLYTVMAFDRYVAICHPlrYLLIMnRRVCALLAASNWIASSFHATIVTSLtFTLPYCGSNVVDYYfCDIFTVANLACGDk 439
gi 558190494 106 LLYTVMAFDRYVAICHPlrYLLIMnWRMCALLAAVAWIASSFHATILTSLtFTLPYCGSNVIDYFfCDIFPVAKLACADt 185
gi 558135497 111 LLCTVMAYDRYVAICHPlrYLLIMnRRVCALLGAGCWITSSLNATVLTSLtFTLPYCGSNVVDCFfCDIFAVIKLACGDt 190
gi 558204115 114 LLYSVMAYDRYVAICHPlrYLLIMnRRVCALLAAGTWITSSFHATILTSLtFTLPYCGSNVVDYFfCDIFPVAKLSCGDt 193
gi 641785334 120 LLYTVMAYDRYVAICHPlrYLVIMnRRVCALLAAGTWITSSFHATILTSLtFTLPYCGSNVVDYFfCDIFPVVKLACADt 199
gi 440900175 113 LLYTVMAYDRFAAICHPlrYAIIMnRQACALLVAGTLAISSFHATSLTTLtFELPYCGSNEIDYFfCDIFPVVKLACSNt 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  ### ### ##                                            #  ## ##  #   ## ### 
gi 74760322  193 slAQRVSFTNVGLISLVCFLLILLSYTRITISILsirttEGRRRAFSTCSAHLIAILCAYGPIITVYLQPtpNPMLGTVV 272
gi 47576217  191 slARTVSFTNVGVIALTCFLLILTSYTRIVISILqihssEGRHRAFSTCSAHLTSIILVYGPVILVYLRPasSPWLDSVV 270
gi 47576257  191 saLEMVGFISVGLMPLSCFLLILTSYSCIVCSILqirsaEGRRRAFSTCSAHLTAILLFYMPVVLIYLRPtpSPWLDATV 270
gi 38372737  191 slAQRVGFTNVGLLSLICFFLILVSYTCIGISISkirsaEGRQRAFSTCSAHLTAILCAYGPVIVIYLQPnpSALLGSII 270
gi 85700374  191 klARKVGSINVGFLALMLLFSVCVSYVHIGVAILrirsaEGRQKAFSTCSAHLTAILCAYGPVIIIYLQRtpNPLLGAVV 270
gi 444518996 211 liIETVSFTNIGLVPMTCFLLIFASYIRIVIAILkmrsaEGRRKAASTCVSHLSVVTLFFGPCALIYTQPslSEVLVTPV 290
gi 530651307 193 yiIETVTLTNIGLVPMTCFLLILASYIRIIYSVLnmnsaEGWRKAASTCASHLVVVTLFFGPCVLIYTQPqpSKVLMTAV 272
gi 558174710 440 yiLETVVFTNTGVVPMSCFVLILASYVRIVFCILkmnagEGRRKATSTCASHLVVVTMFFGPCALIYTQPqlSKVLVTPV 519
gi 558190494 186 yiLETVTFTNIGVVPMTCFILILASYIRIVYCILkmnvgEGRRKAASTCASHLAVVTLFFGPCALIYTHPemSKVLVTPV 265
gi 558135497 191 siIKTVSFTNIGVAPTICFTLILASYVRIAASVVrmrsmKHVRKAISTCSSHVIVVCFFFGPSAVLYTQPsvSNLLATPT 270
gi 558204115 194 yiLETVIFTNSGMVSAPCFLLILASYVHIFYSVVkmnsaEGRQKVASTCSSHLAVVTLFFGPCALIYTQPqqNMVMVTAV 273
gi 641785334 200 yvIETVTFTNTGMVPTACFLLILASYICIVYSVLkmnsaEGRRKAVSTCGSHLVVVTLFFGPCTLVYTQPqlSKVLVTPV 279
gi 440900175 193 lvIETVSFTNIGLIPMICFLLIVCSYLRIVTAVLkmhsaEGRHKAASTCASHLSVVTLFFGPCALVYTQPslSEVLVTPV 272
                        330       340
                 ....*....|....*....|....*..
Feature 1         #  ##                     
gi 74760322  273 QILMNLVGPMLNPLIYTLRNkEVKTAL 299
gi 47576217  271 QVFNNVVTPSLNPLIYTLRNkDVKLAL 297
gi 47576257  271 QVLNNLVTPMLNPLIYSLRNkEVKSSL 297
gi 38372737  271 QILNNLVTPMLNPLIYSLRNkDVKSDQ 297
gi 85700374  271 QILNNIVSPMLNSLIYSLRNkEVKRSL 297
gi 444518996 291 QIFGNVVTPMLNPTIYTLRNkDVKGAL 317
gi 530651307 273 QIFGNVVTPMLNPAIYTLRNkEVKAAL 299
gi 558174710 520 NIFGNLITPMVNPAIYTLRNkEVKAAL 546
gi 558190494 266 DIFGNLVTPMLNPAVYTLRNkEVKAAL 292
gi 558135497 271 QIFSVVLTPMLNPLVYTLRNkEVKAAF 297
gi 558204115 274 HIFGSVVTPMLNLAIYTLRNkEVKAAL 300
gi 641785334 280 QIFSNVVTPMLNPAIYTLRNkEVKAAL 306
gi 440900175 273 QIFASVITPMLNPTIYTLRNkDVKGAL 299

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