Conserved Protein Domain Family
7tmA_OR13-like

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cd15232: 7tmA_OR13-like 
olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320360
View PSSM: cd15232
Aligned: 25 rows
Threshold Bit Score: 421.281
Threshold Setting Gi: 395509502
Created: 17-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 229462928  43 VFLFSCFLFLYSGALTGNVLITLAITFNPGlhaPMYFFLLNLATMDIICTSSIMPKALASLvseeSSISYggCMAQLYFL 122
gi 602666140  68 LLLFWVFAFIYATGLAANLLLLITISTFKKlhtPMYFLIFNLSLVNIFSISITTPRLLQSLlthrNMVSFygCITQVFFI 147
gi 602677836  16 TLLFWVFMIIYTTALCANILLILTICTFRKlhsPMYFFTVNLSLVNVFSISVTTPKLLQSLwtgrKTISFygCIAQLYLF 95
gi 637331527  16 TLLFWIFTFIYAIALTFNCLLIFTICNCRNlhtPMYFLLINLSLVNIFSISVTTPKLLQALwtqrKIISFygCITQVYLF 95
gi 602666138  27 MFIFWIFAVIYASALAGNFLLILAIGICSKlhtPMYFLLVNLSVVNVCSISVTVPKMLQNIldqkRTISFlgCIVQVFLF 106
gi 637331523  23 MILFWLFSFIYAVAVISNILTILAINTCSKlhtPMYFLLVNLSVINICSVSVIVPKMLQTIlaerKSITFtgCIAQVYLF 102
gi 602673785   3 IILFWIFIFIYITALSANFLLILTVCTFRKlhtPMYLFIVNLSLVNVFSISITIPKLLHSLltgrQTISFhgCLTQVYMF 82
gi 612000205  23 LFLLVSFLCIYVTALVGNSLIFFTICASQQlhtPMYFFLGNLSVIDVLCTSTIMPKMLANLyfqrADISFlgCMAQMYLF 102
gi 530580856  23 MFLFVLFTSIYMAALTGNLLIVLTITTSTSlhtPMYFLLINLSLINLLSISVSIPKMLHNLlehkKTIAFlgCITQIYLF 102
gi 602677998  31 TLLFWSFIFSYVIALVGNFLLISIIWTSKKlhtPMYFLLVNLSLVNVLSISTTTPKLLLTLlsyeSTISFygCITQVFFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 229462928 123 TWAAsSELLLLTVMAYDRYAAICHPlhYSSMMsKVFCSGLATAVWLLCAVNTAIHTGLMlrLDFCGPNVIIHFFCEVPPL 202
gi 602666140 148 IWALgSEMLLLSFMAFDRYAAICHPlhYNIIMrKEVCVGIATTVWIAGMIDSAIHAGLMlpLSFCDSNVINHFFCDIPPV 227
gi 602677836  96 IWALgTELLLLSFMAFDRYAAICHPlqYTMIMrKEVCFGIASIVWIAGMMNSAVHACLMlkLSFCNSNVINHFFCDAPPL 175
gi 637331527  96 IWTLgTELLLLSFMAFDRYTAICHPlqYTLIMrKEACVCIAVGAWLVGMVNSAVHAGLMlkLSFRDSNIINHFFCDVPPL 175
gi 602666138 107 VWALgTEILLLSFMAFDRYAAICQPlhYTVIMkKEVCVGIATGAWVIGMANSAVHAGLLlrLSFCESEDINHFFCDLPPL 186
gi 637331523 103 NLMLgTELMLLALMAFDRYAAICHPfqYMVIMrKEFCLGAVTGLWLIGMANSAIQTGLVaqLSFCDSNVINHFFCELPPM 182
gi 602673785  83 IWAVgTELLHLSFMAFDRYAAICHPfqYHMIMrKQVCVCAAVGVWVVGLVNTSTHSALLnqLSFCNTNIINHFFCDLPPL 162
gi 612000205 103 TWALvSEVLLLALMAFDRYVAICHPlhYSMVMrSHVCIGMAGSIWAIGICNSAVHTSLAipLSFCSSFIIDHFFCELPPI 182
gi 530580856 103 TWTLgSEALVLAAMAFDRYAAVCHPlhYTIIMrKEVCVGLIAGIWIAGVINSAVNTGFVlqLSFCDSNIINHFFCELPPV 182
gi 602677998 111 ILFMvTELLLLTSMAFDRYVAICYPlqYTLIMrKEICAAIAVGAWASGLINSSVHSGLVlqLSFCESNIINHFFCDLPPL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 229462928 203 LLLSCsstyvNGVMIVLADAFYGIVNFLMTIASYGFIVSSIlkvktaWGRQKAFSTCSSHLTVVCMYYTAVFYAYISPvs 282
gi 602666140 228 LDLACsdtsrNESMTKVANVVYGMGSCGLTLTSYFFIMRTIfrirstEGKKKAFSTCSSHLLVVSFYFSAIIYMYIRPss 307
gi 602677836 176 MHLSCsdtslNESMAFVSDVTFGIVCCGLTLTSYFLIIRAIcrirstEGKKKAFSTCSSHFIVVSIFYSSVIYTYIRPts 255
gi 637331527 176 LKLASsdtsiNESMAFAADVILGIFNCGLTLMSYFFIMRTIfrirstEGKKKAFSTCSSHLIVVSFYFSSVIYTYIRPss 255
gi 602666138 187 WKLSCsdislNEIMAFAADVTFTMSSCTLTLISYLLILRTIikiqsvKGKKKAFSTCSSHLLVVSFYFSTIIYTYAKPst 266
gi 637331523 183 FNISCsdtslNESMVFVASVTIVIGSCAVTLTSYCFIVRDIikirstESKRKAFSTCSSHLLVVSFYYSTIIYTFLRPas 262
gi 602673785 163 LHLSCsdsalSVVVLSASDWILGVGCCGFTLTSYFFIIRTIcrirstEGKKKAFSTCSSHFFVVSIFYSSVIYTYIRPss 242
gi 612000205 183 LKLSCsdtslNEALAFCADVIFGVGSCSLILVSYGCIIRTIlkirssEGKKKAFSTCSSHLTVVSFYYSTVIYTYIRPts 262
gi 530580856 183 LQLSCsdislNETLTFLADTVFGMGSCVVTLTSYYFILRTIlkirstEGKKKAFSTCSSHLIVVILYYSTAIYTYIHPss 262
gi 602677998 191 FKLSCsdtslNETMASVADIIFAVFGCGLTLTSYGFIIRTIfrirstKGKKKAFSTCSSHLIVVTFFFSSVIYTYIRPts 270
                        250       260       270
                 ....*....|....*....|....*....|
Feature 1           ## ###  #  ##              
gi 229462928 283 gySAGKSKLAGLLYTVLSPTLNPLIYTLRN 312
gi 602666140 308 aySLDKDKLVSLIYSMATPVVNQQIYSLRN 337
gi 602677836 256 vySPDQDKKIALLYSVVTPVLNPVIYSLRN 285
gi 637331527 256 vySLDKDKLVSLLYTVVTPVLNPIIYFMRN 285
gi 602666138 267 pnDEEEYKNIAIIYSVVTPVLNPIIYSLRN 296
gi 637331523 263 aySLEEDKVIAIIYSVLIPVLNPLIYSLRN 292
gi 602673785 243 ayAPEQDKIVALLYSVVTPLANPVIYSLRN 272
gi 612000205 263 nlSLGRDKVITALYSVIIPMLNPMIYSFRN 292
gi 530580856 263 aySPDRDKVITVLYSVITPALNPIIYSLRN 292
gi 602677998 271 vfSLNRDKYISLLYSVVTPVINPVIYSLRN 300

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