Conserved Protein Domain Family
7tmA_OR3A-like

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cd15233: 7tmA_OR3A-like 
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320361
View PSSM: cd15233
Aligned: 6 rows
Threshold Bit Score: 441.154
Threshold Setting Gi: 444510543
Created: 17-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 226694174  34 PVVFVLLLFAYLVTTGGNLSILAAVLVEPKLHaPMYFFLGNLSVLDVGCITVTVPAMLGRLLshkSTISYdaCLSQLFFF 113
gi 85541039   28 PILFVVFFFAYIVTVGGNLSILAAIFVEPKLHtPMYYFLGNLSLLDIGCISVTVPPMLVCLLaheCRVPYaaCISQLFFF 107
gi 269849760  28 PILFVIFLLAYVTTIGGTLSILAAILMETKLHsPMYFFLGNLSLPDVGCVSVTVPAMLSHFIsndRSIPYkaCLSELFFF 107
gi 620967732  29 FVAVPTDPPGHYLGGGGNLSIILAILLEPQLHnPMYFFLGNLSLTDISCITVTVPHRLGNLLsqkKTISLagCLAQLFFF 108
gi 444510543  25 PLLFAVFLLIYIVAIVGNLGIVSLIVLDSRLHtPMYFFLGNLSLLDAAYISNTVPQVLVHLLaavRTMPYhsCLIQIFFL 104
gi 431911586 173 PLLFATFLLVYIVAVVGNLGIFCLIVIDSRLHtPMYFFLANLSLLDTAYISNTVPQVLVHLLapvRTMSYraCLTQIFFL 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 226694174 114 HLLAGMDCFLLTAMAYDRLLAICQPLtYSTRMsQTVQRMLVAASWACAFTNALTHTVAMstLNFCGPNEVNHFYCDLPQL 193
gi 85541039  108 HLLAGVDCHLLTAMAYDRYLAICQPLtYSTRMsREVQGTLVGICCTVSFINALTHTVAVsvLDFCGPNVVNHFYCDLPPL 187
gi 269849760 108 HLLAGADCFLLTIMAYDRYLAICQSLtYSSRMsWGIQQALVGMSCVFSFTNALTQTVALspLNFCGPNVINHFYCDLPQP 187
gi 620967732 109 HLLTGANCFLLTAMAYDRXLAICHPLdYRARMkWSVQVALVGASWACAXTNALTHTVAMstLYFCGPNVINHFFCDIPPL 188
gi 444510543 105 HFLAPWECFLLTAMAYDRYAAICQPLyYLVLMgRRTRTGLTSISCLLALTNALTHTILAalLKFCGPRLVTHFFCDLPPL 184
gi 431911586 253 HFLAPWECFLLTAMSYDRYAAICQPLhYLVLMgQRTRTGLAVISCLLALANSLTHTILAalLKFCRPRLITHFFCDLPPL 332
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 226694174 194 FQLSCSStqlNELLLFVAAAFMAVAPLVFISVSYAHVVAAVLQiRSAEGRKKAFSTCGSHLTVVGIFYGTGVFSYMRLGS 273
gi 85541039  188 FQLSCSSiylNGQLLFVGATFMGVVPMILISVSYAHVAAAVLRiRSTEGRKKAFSTCGSHLTVVCIFYGTGFFSYMRLGS 267
gi 269849760 188 FQLSCSSvhlNGQLLFVAAAFMGVAPLVLITVSYAHVAAAVLRiRSAEGRKKAFSTCSSHLTVVGIFYGTGVFSYTRLGS 267
gi 620967732 189 CQLSCSSnhhNQLLLFVTVIFMALIPIGFLVLSYTHIVVAILRlRSAEGLRQTFSTCASHLIMVCIFYGTGIFSYMRLGS 268
gi 444510543 185 LKLSCSStraNELALFFFSFIVALAPCALVVISYIYVVAAVVRiRSAEGRRKAFSTCGAHISIVCIFYLTSVLCYILPSS 264
gi 431911586 333 LKLSCSStqaNELALFFFSFLVALAPCTLVVISYIHVVAAVLRiRSAEGRRKAFSTCGAHITMVCIFYITSVLCYILPSS 412
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1           ## ###  #  ##                     
gi 226694174 274 veSSDKDKGVGVFMTVINPMLNPLIYSLRNtDVQGAL 310
gi 85541039  268 vsASDKDKGIGILNTILSPMLNPLIYSLRNpDVQGAL 304
gi 269849760 268 veSSDKDKGIGILNTVISPMLNPLIYWTSLlDVGCIS 304
gi 620967732 269 gdASEKDKVIGILNSIVSPTLNPLIYSLRNaEVKGAL 305
gi 444510543 265 aySRLRDRVLSVLYVVLTPMLNPIIYSMRNkEVKKAL 301
gi 431911586 413 aySGLRDRVLSVLYVVLTPMLNPIIYSMRNkDVKRAL 449

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