Conserved Protein Domain Family
7tmA_OR1A-like

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cd15235: 7tmA_OR1A-like 
olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320363
View PSSM: cd15235
Aligned: 29 rows
Threshold Bit Score: 405.838
Threshold Setting Gi: 47575969
Created: 4-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #  ##           ######
gi 212276451  24 EDFFYILFLFIYPITLIGNLLIVLAICSDVRLh-NPMYFLLANLSLVDIFFSSVTIPKMLANHLLgsKSISFgGCLTQMY 102
gi 47577341   24 QPVIFGVILTMYLMSVLGNTLLVLVACSDPKLq-TPMYFLLSQLSLIDISLTTITIPQMLVHTFSvdRSISYnRCMTQLF 102
gi 85681882   24 QIPLFLVFSLMYAINISGNLAIITLILSAPRLh-IPMYIFLSNLALTDICFTSTTVPKMLQIIFSptKVISYtGCLAQTY 102
gi 585677019  24 QPFLFGLFLAMYLVTIMGNLFIILAIGFDVHLh-TPMYFFLANLSVSDIGFISTTVPKMLDNIGSgsKLISYgECLAQLY 102
gi 620969422  23 QRLLFVLFLGLYLVTVVGNLLIVLTIRTDSRLh-SPMYFFLANLSLVDICFSCTTVPSLLGTLFTghQDISYgGCLAQMY 101
gi 602665563 197 NILLFAIFLTMYVITVLGNLIIILAIRLDSHLh-TPMYYFLSNLSLVDICFTSTTVPKMLAGEFSgkRKISYgGCLSQMY 275
gi 564252266  24 QGPLFALFLAMYLASALGNATILAAIHMNNHLlhAPMYFFLNHLSLVDLGLTSAVVPKLLAGTLTgdWGISYaGCLAQMY 103
gi 334311487  24 QPVIFGVIFAMYLITIVGNSMIITVTWIDPKLk-TPMYFLLSQLSIIDICFTTITVPQLLIHTFSrsKTISFtQCMTQVF 102
gi 602669469  24 QPLFFLLFLLMYSAGLLGNTMMLLLITLDVQLq-TPMYFLLRSLSVIDLGFISVTVPQMLVHIVSasRTIPFySCMAQFF 102
gi 602665565  24 EGPLFSLFLFMYLLTFLGNSLIILLILFDAHLcgLPMYFFLIQLSLVDICFSSATTPKMLEILLSknKTISYtECLLQLY 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 212276451 103 FMIALGNTDSYILAAMAYDRAVAISRPLHYTTIMSPRSCIWLIAGSWVIGNANALPHTLLTASLSFCgnqEVANFYCDIT 182
gi 47577341  103 FFMAVGSMEGHLLAAMAYDRYVAICDPLRYSAIISHRLCLRITLTSWVVVSLNSLLYSVLVTRLTFCg-nQVTHFFCDIT 181
gi 85681882  103 FFICFAVMENFILAVMAYDRYIAICHPFHYTMILTRMLCVKMVVMCHALSHLHAMLHTFLIGQLIFCadnRIPHFFCDLY 182
gi 585677019 103 FFGLFADLDNFLLAVMALDRYVAISYPLHYATRMNSQRCILLVAGSWVVTTFHALLHTLLVTRLSFCgpsIIPHFFCDLY 182
gi 620969422 102 FFIAFGITESCLLAAMAYDRYLAICNPLLYSVVMSPQRCVLLVVTCWLVSHLHSLLHTLLMTQMTFCasrEIPLFFCDVF 181
gi 602665563 276 FFIAFGVTDSFLLASMALDRYVAICQPLRYATMMRKQICLSLVVTSWLASHLHSLLHTLLMSRLSFCassHVPHFFCDVF 355
gi 564252266 104 FFIAFGITDSFLLAAMALDRYMAVCHPLRYAIIMSPRFCWALVTSSWLVAHLHSLLHTLLMSRLSFCatrHVACFFCDVF 183
gi 334311487 103 FFVAVGNMEGYLLATMAYDRYVAICNPLRYGAIVTQKFCVSIVLVSWLLMFLNSLLHTILVSRLNFCs-nHILHFFCDLP 181
gi 602669469 103 FFYVFGVTDLLLVSVMALDRYVAICNPLHYASVMNQKVCGQLVAGCCIISTLHSMLHAGLLLRLTYRgknHLPHYFCDHQ 182
gi 602665565 104 LLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCgslEISHFFCDIR 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #  ### ### ##                                            #  ## ##  #
gi 212276451 183 PLLKLSCSDi-HFHVKMMYLGVGIFSVPLLCIIVSYIRVFSTVFqvpstKGVLKAFSTCGSHLTVVSLYYGTVMGTYFRP 261
gi 47577341  182 PLLKLSCTRpvLNEMLIFTEGVVVVVSPFFFILGSYVRIGFAIAhmhsiTALRKALSTCGSHILVVLLLYGSVIRMYLKP 261
gi 85681882  183 ALMKISCTStyLNTLMIHTEGAVVISGALAFITASYACIILVVLripsaKGRWKTFSTCGSHLTVVAIFYGTLSWVYFRP 262
gi 585677019 183 PFLSISCSSthLNTLMIQTEGVIGINGALIFTIASYTCIITAVLripsaNGKWKAFSTCGSHLTVVAIFYGTLTWVYFRP 262
gi 620969422 182 PLLKISCSDphINFLVVYTEGAVIVNSALLMVLASYAHIVPAVLrvpsaHGKRKAFSTCSSHLAAVGLFYGTVIWVYFQP 261
gi 602665563 356 PLLKISCSNtaLNTLVVHSEGAFIVNGALMVIGLSYAHILMAVLrvpsaKGKKKAFSTCGSHLTVVSLFYGTVIWVYFQP 435
gi 564252266 184 PLLKLSCSNarLNVLVVHTEGAMVVNGALLFILLSYTRIAAAVLkvpsaAGKRKAFSTCGAHLTVVGLFYGTIIWVYFQP 263
gi 334311487 182 PLMQLSCSRpfINEIIILTEGVAATLSPFVFILASYVCIAVTVLglrstAGLRKAVSTCGSHIVVVTLFYGTIIRLYFQP 261
gi 602669469 183 PLLQLSCSDisVNEAVIFFEGVIIILGPFVFIILTYIRIVATIMkf-tsLGRRKAFSTCGSHLTIVILFYGAIIAVYFLP 261
gi 602665565 184 ELLSLSCSDvsIHQMIIFIEGASVTLSPLVCILLSYVQILSNILkipnaQGKYKAFSTCGSHILSVAFYFGSIMGVYFQP 263
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1               ## ###  #  ##                     
gi 212276451 262 Lt---nYSLKDAVITVMYTAVTPMLNPFIYSLRNRDMKAAL 299
gi 47577341  262 Ssi--yELDQDRQIAIFYTLITPMLNPLIYSLRNHEVKGAV 300
gi 85681882  263 Lss--ySVTKGRIITVVYTVVTPMLNPFIYSLRNGDVKGGF 301
gi 585677019 263 Lss--ySVAQARIVTVMYTVVTPMLNPFIYSLRNGDVKVTF 301
gi 620969422 262 Sss--fSSERDTIATVIYTTITPLLNPFIYSLRNRDLHRAL 300
gi 602665563 436 Ssn--fSAKTDTLAAIMYTMVTPMLNPFIYTLRNDRMKEAL 474
gi 564252266 264 Sas--fSAEKDLLAAIMYTMVTPMLNPFIYTLRNDEMKGTL 302
gi 334311487 262 Vss--yTLDRDRQVAVFYTVVTPMLNPIIYSLRNQEVKGAL 300
gi 602669469 262 Tss--ySSQRGSFFALVYTVITPMSNPYIYSLRNKEVKDAL 300
gi 602665565 264 SspersTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304

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