Conserved Protein Domain Family
7tmA_OR1E-like

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cd15236: 7tmA_OR1E-like 
olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320364
View PSSM: cd15236
Aligned: 7 rows
Threshold Bit Score: 408.387
Threshold Setting Gi: 471370706
Created: 11-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372762   25 AVFFALFLGMYLTTVLGNLLIMLLIQLDSHlhtPMYFFLSHLALTDISFSSVTVPKMLMNMqtqhLAVFYkgCISQTYFF 104
gi 504168970  25 NLFYVLFLAMYLTTVLGNLLIIVLIRLDSHlhtPMYLFLSNLSFSDLCFSSVTVPKLLQIMnsqdPSIPYaaCLTQMYFF 104
gi 47577263   25 NVFFTLFLAMYLTTVLGNLLIILLIRLDSHlhtPMYFFLSHLAFTDISLSSVTVPKMLMNIqaqqHSISYkgCISQMYFF 104
gi 9297116    25 NLCYALFLAMYLTTLLGNLLIIVLIRLDSHlhtPVYLFLSNLSFSDLCFSSVTMPKLLQNMqnqdPSIPYadCLTQMYFF 104
gi 471370706  25 GMFFALFLGMYLTMVKGNLLIILLIRLDSRlhtPMYFFLSHVAFSDVSFSSVTIPKMLINMhtqdQSIPYvdCISQMYFF 104
gi 556757367  25 GVFFALFLSMYLTTVLGNLLILLPIRLDPRlhtPMYFFLSHLGLTDVSFSSVTLPKMLVNMqtrcQAITYagCISQVYCI 104
gi 440899796  25 GVFFALFLGVYLTTVLGNLLILLLIRLDPRlhtPMYFFLSHLALTDVSFSSVTLPKMLMNMqtrcQAITYagCISQVYCF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                                                # #####     
gi 38372762  105 IFFADLDSFLITSMAYDRYVAICHPlhYATIMt--------------------QSQCVMLVAGSWVIACACALLHTLLla 164
gi 504168970 105 LFFGDLESFLLVAMAYDRYVAICFPlhYTSIMs--------------------PMLCLTLVALSWVLTTFHALLHTLLma 164
gi 47577263  105 VLFGCLDNFLLAVMAYDRYVAICHPlhYITIMr--------------------EELCFFLVAASWFFCCVHALLHTLLli 164
gi 9297116   105 LYFSDLESFLLVAMAYDRYVAICFPmhYTAICfllhy-----------taimsPMLCLSVVALSWVLTTFHAMLHTLLma 173
gi 471370706 105 TFFVCLNNLLLIVIAYDRFVAICHPlhYTTIMr--------------------EELCILLVVGFRFFSCVHVLLHTLLls 164
gi 556757367 105 IFFSCLDSFLLAVMAYDRYVAVCHPlhYTAIMr--------------------DELCVILVAGCWLAACAQALLHTLLvd 164
gi 440899796 105 IFFGCLDSFLLAVMAYDRYVAVCHPlhYTAIMrdelcvilvagqplhyaitmnSQRCILLVAGSWVVTTFHALVHTLLvt 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                       #  ### ### ##                                    
gi 38372762  165 qLSFCADHIIPHY-FCDLGALLKLSCSDtslNQLAIFTAALTAIMLPFLCILVSYGHIGVTILQip-stKGICKALSTCG 242
gi 504168970 165 rLFFCADNVINHF-YCDLPQLFQLSCSStqlNELLLFAVGFIMAGTPVALIVTSYANVAAAVLRir-saEGRKKAFSTCG 242
gi 47577263  165 qLSFCASNIIHNF-FCDLTPLLELSCSDislNKLVIFTEGGLLFILPLSSVMGSYILIGCTALKap-stKRFIKTFSTCG 242
gi 9297116   174 rLCFCADNVIPHF-FCDMSALLKLACSDtrvNEWVIFIMGGLILVIPFLLILGSYARIVSSILKvp-ssKGICKAFSTCG 251
gi 471370706 165 rLSFCADNTIPYF-FCDLTALLKLTSSAiylKELVIFTEGGVLVVLPLSAILGSYVSIGATILKvp-stKWICKALSTCG 242
gi 556757367 165 qLTFCAGTVIPHFcDLAVVLKSSCSNTSl--NELLILTEGGLIFTLPLGGILGSYIRMAAIILKvpsltRIFKALSTCGS 242
gi 440899796 185 rLSFCGPNVIPHF-FCDLVPLLKLACSSthvNDMVLILVAGTLLIAPFVCILTSYFYIALAILGid-spKGKQKAFSNCT 262
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                 #  ## ##  #     ## ###  #  ##                          
gi 38372762  243 SHLSVVTIYYRTIIGLYFLPpssnTNDKNIIASVIYTAVTPMLNPFIYSLRNk-----DIKGAL 301
gi 504168970 243 SHLTVVAIFYGSGIFNYMRLgstkLSDKDKAVGIFNTVINPMLNPIIYSLRNp-----DVQAAL 301
gi 47577263  243 SHLLVVFLYYGTVACEYFFSsfqnSSDKDIVASVFYAVVTPLMNPFIYSLRNr-----DIKQAL 301
gi 9297116   252 SHLSVVSLFYGTVIGLYLCPsansSTLKDTVMAMMYTVVTPMLTPFIYSLRNr-----DMKGAL 310
gi 471370706 243 SHLSVVFLYYGTLAIIYFFPssnnSQIKDIIASVMYTVVTAMLNPFIYNLRNr-----DMKLAL 301
gi 556757367 243 HHLFVVFLYYGTIAGVYYFPssgnSKVKDIVASLMYTVVTPTEQQPLLFGLFlgmylvTVWGNL 306
gi 440899796 263 SHLSVVSLFYTTAIGVYLCPpsspSGGKDRVFSVMYMVVTPLLNPFIYSLRNr-----DIKGAL 321

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