Conserved Protein Domain Family
7tmA_OR2-like

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cd15237: 7tmA_OR2-like 
olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320365
View PSSM: cd15237
Aligned: 17 rows
Threshold Bit Score: 377.387
Threshold Setting Gi: 38372645
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372774   25 PILFVFIFIFYSLTLFGNTIIIALSWLDLRlhtpMYFFLSHLSLLDLCFTTSTVPQLLINLcgvdRTITRggCVAQLFIY 104
gi 229462940  75 GLIFAIISIIFFTALMANGVMIFLIQTDLRlhtpMYFLLSHLSLIDMMYISTIVPKMLVNYlldqRTISFvgCTAQHFLY 154
gi 14423818   26 KTFFVLILLMYLVILLGNGVLILVTILDSRlhtpMYFFLGNLSFLDICFTTSSVPLVLDSFltpqETISFsaCAVQMALS 105
gi 84029381   24 ILLCGLFSVFYTLTLLGNGVIFGIICLDSKlhtpMYFFLSHLAIIDMSYASNNVPKMLANLmnqkRTISFvpCIMQTFLY 103
gi 602668177  25 PLLFILFFTMCLITVLGNSLIIFLVWINSRlhtaMYFFIGNLSLLDIFFTLITTPQMLAHMvsetKVISFnrCMAQLNLT 104
gi 38372645   25 DTFFTLVLIIYLSTLLGNGFMIFLIHFDPNlhtpIYFFLSNLSFLDLCYGTASMPQALVHCfsthPYLSYprCLAQTSVS 104
gi 22129632   28 SILFIVFLLIYLSSVLGNGLIIMLVCLDTQlhtpMYFFLSTLSLLDMSYVTTTMPQMLVHLlahsQTISFvgCWLQMFVF 107
gi 564247125  25 ELLFTLFLLIYVVTLAGNGIIIVITSIDPRldtpMYFFLRNLSIIDICYISSTVPQLLVHFlsqtHTISLvaCALQNYAF 104
gi 543740539  25 TFLFIVFLIFYLFTVVGNIVIITVIRADYQlqspMYFFLANLSFLDICYISSNIPQMLVNLstkkRTISFsgCATQMYFY 104
gi 557293921  25 TLLFVLFLAMYLVTLSGNAVMVLLIGVDPRlrtpMYFFLLHLSLLDMCYSSVTVPQMLVHLlsvhKALPFarCALQMYIF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372774  105 LALGSTECVLLVVMAFDRYAAVCRPlhYMAIMhPHLCQTLAIASWGAGFVNSLIQTGlamaMPLCGH-RLNHFfCEMPVF 183
gi 229462940 155 LTLVGAEFFLLGLMAYDRYVAICNPlrYPVLMsRRVCWMIIAGSWFGGSLDGFLLTPitmsFPFCNSrEINHFfCEAPAV 234
gi 14423818  106 FAMAGTECLLLSMMAFDRYVAICNPlrYSVIMsKAAYMPMAASSWAIGGAASVVHTSlaiqLPFCGDnVINHFtCEILAV 185
gi 84029381  104 LAFAVTECLILVVMSYDRYVAICHPfqYTVIMsWRVCTILVLTSWSCGFALSLVHEIlllrLPFCGPrDVNHLfCEILSV 183
gi 602668177 105 LSCGITECFILALMAYDRYVAICWPlrYPIVMrMSMCMQMAGICWFGGFFNAAALTVctvnFPFCGPnEINHFfCEAPAV 184
gi 38372645  105 LALATAECLLLAAMAYDRVVAISNPlrYSVVMnGPVCVCLVATSWGTSLVLTAMLILsl-rLHFCGAnVINHFaCEILSL 183
gi 22129632  108 SALGITECTFFVVMAYDRYVAICYPlrYTVILnWGLCIHLTAGSWVCGLFSSLLHTFftmsLPYCGPnRVNHYfCEGPSV 187
gi 564247125 105 FAFGVTECFLLAVMAYDRYVAICNPlnYTLVMsRYACGKMAVASWVSGFLHSVVLTVytfhVPFCGSnQIDHFfCEAPQV 184
gi 543740539 105 FAFGTTECVLLAVMAYDRYMAICHPllYATAMnKKVCIHMVVASWTSSLLSSMVINSftlwLPFCGPhILNHYfCEVPAV 184
gi 557293921 105 LAFGMAECVLLAIMAYDRYVAICYPlhYGTIMsRHLCSRMAAAAWVSGFLNSLIVNAfalhLPYQGPsHINQFfCEVPAV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 38372774  184 LKLACadtegTEAKMFVARVIVVAVPAALILGSYVHIAHAVlrvkstAGRRKAFGTCGSHLLVVFLFYGSAIYTYLQSih 263
gi 229462940 235 LKLACadtalYETVMYVCCVLMLLIPFSVVLASYARILTTVqcmssvEGRKKAFATCSSHMTVVSLFYGAAMYTYMLPhs 314
gi 14423818  186 LKLACadisiNVISMEVTNVIFLGVPVLFISFSYVFIITTIlripsaEGRKKVFSTCSAHLTVVIVFYGTLFFMYGKPks 265
gi 84029381  184 LKLACadtwvNQVVIFATCVFVLVGPLSLILVSYMHILGAIlkiqtkEGRIKAFSTCSSHLCVVGLFFGIAMVVYMVPds 263
gi 602668177 185 FQLACmdtyvMKVFIFALSVIVLMLPLSFIVLSYLQIARLVfnmhsaEGQQRAFSTCATHLIIVVLFYSTISFTYLQPes 264
gi 38372645  184 IKLTCsdtslNEFMILITSIFTLLLPFGFVLLSYIRIAMAIirirslQGRLKAFTTCGSHLTVVTIFYGSAISMYMKTqs 263
gi 22129632  188 RSLACmdthvIEMVDFVLSVFVIVIPISLIVASYIGIAKAIlkikstEGRCKAFSTCASHLTVVTFFYAPATYIYMRPns 267
gi 564247125 185 LKLACtdtylNELVIFAVAILVLIIPLSLVFVSYSQILTTIlrmttaAGRRKTFSTCASHLTVVSLFYGAAIFMYMWPkt 264
gi 543740539 185 LALACahtalMKLVIFIFSILIVFTPFLLIVASYARILSTIlkirsaRVQSKTFSTCGSHLMVVTVFYGTAIYMYMNPks 264
gi 557293921 185 IKLASadtttAEVVVFVFGTLLLLVPFLLIAASYGRILAAIlrihsvEGRHRAASTCASHLLVVSLFYGTAVFAYMRPts 264
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1                 ## ###  #  ##              
gi 38372774  264 ------nySEREGKFVALFYTIITPILNPLIYTLRN 293
gi 229462940 315 ------yhKPAQDKVLSVFYTILTPMLNPLIYSLRN 344
gi 14423818  266 kdsmgadkEDLSDKLIPLFYGVVTPMLNPIIYSLRN 301
gi 84029381  264 ------nqREEQEKMLSLFHSVFNPMLNPLIYSLRN 293
gi 602668177 265 ------dhSADQEKKAAVFYSLVSPMLNPLIYSLRN 294
gi 38372645  264 ------ksYPDQDKFISVFYGALTPMLNPLIYSLRK 293
gi 22129632  268 ------sySPERDKQISLFYNTFTALLNPVVYSLRN 297
gi 564247125 265 ------shSAQQDKMISLFYAVITPMINPMIYSLRN 294
gi 543740539 265 ------rpPQDKDKVVAVFYTIVVPMLNPLIYSLRS 294
gi 557293921 265 a-----tsSTGQDKAVSIFYTVVTPMLNPLIYSLRN 295

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