Conserved Protein Domain Family
7tmF_FZD5

?
cd15249: 7tmF_FZD5 
class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors
This group includes subfamily 5 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and its closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.
Statistics
?
PSSM-Id: 320377
View PSSM: cd15249
Aligned: 4 rows
Threshold Bit Score: 643.149
Threshold Setting Gi: 17432995
Created: 22-Jan-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human smoothened receptor bound to an antitumor agent.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #        #                                                 #                  #
gi 17432995  212 PYFTQDEKMFVTFWIGLWSILCFISTFTTVATFLIDMERFRYPERPIIFLSACYLFVSIGYVVRLIVgHENVACN----K 287
gi 465951400  75 PYFTQDEKTFASFWIGLWSILCFLSTSTTVATFLIDMERFRYPERPIIFLSACYLFVSLGYIVRLVAgHASVACNq--eY 152
gi 116242481 225 PSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVgHASVACSr--eH 302
gi 190337522 235 PYFSQDERTFTTFWIGLWSVLCFVSTFTTVATFLIDMERFKYPERPIIFLAACYLFVSLGYIVRLLAgHERVACEgtgdQ 314
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 17432995  288 DHIHYETtGPALCTIVFLLIYFFGMASSIWWVILTFTWFLAAGMKWGnEAIASYSQYFHMAAWLIPSVKSIAVLALSsVD 367
gi 465951400 153 RHVHYETtGPALCTTVFLLLYFFGMASSIWWVILSLTWFLAAGLKWGnEAIAGYSQYFHLAAWLIPSVKAIAVLALSsVD 232
gi 116242481 303 NHIHYETtGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGnEAIAGYAQYFHLAAWLIPSVKSITALALSsVD 382
gi 190337522 315 QHILYDTtGPALCTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGnEAIAGYSQYFHLAAWLVPSVKSIAVLALSsVD 394
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #    # #  ##    #                                                              
gi 17432995  368 GDPVAGICYVGNQNLDNLRGFVLAPLVVYLFSGTMFLLAGFVSLFRIRSVIKqggTKTDKLEKLMIRIGIFSVLYTVPAT 447
gi 465951400 233 GDPVAGVCYVGNQNLGNLRGFVLAPLVVYLLTGTLFLLAGFVSLFRIRSVIKqggTKTDKLERLMIRIGIFTVLYTVPAT 312
gi 116242481 383 GDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKqggTKTDKLEKLMIRIGIFTLLYTVPAS 462
gi 190337522 395 GDPVAGICYVGNQSLEGLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIRSVIKqggTKTDKLEKLMIRIGLFTVLYTVPAT 474
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                    #  ##                  #    #  ##                            
gi 17432995  448 IVVACYIYEQHYREhWEKTHNCSCPGdk---qrYRPDYAVFMLKYLMCLVVGITSGVWIWSGKTLESWKRFTG 517
gi 465951400 313 LVVACYVYEQHYREsWEEAQNCSCPGdp---rkPRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLDSWRRFTG 382
gi 116242481 463 IVVACYLYEQHYREsWEAALTCACPGhdtgqprAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTS 535
gi 190337522 475 IVVACLVYEQHYRPsWERALACSCPSerq-rlgMGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFIA 546

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap