Conserved Protein Domain Family
7tmB2_GPR144

?
cd15255: 7tmB2_GPR144 
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
GPR144 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR133. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.
Statistics
?
PSSM-Id: 320383
View PSSM: cd15255
Aligned: 4 rows
Threshold Bit Score: 441.211
Threshold Setting Gi: 59797942
Created: 5-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #   #                                         #  ##  #      #      #     
gi 59797942   655 ESLLRTLSFVGCGVSFCALTTTFLLFLVAGVpksERTTVHKNLTFSLASAEGFLMTSEWAKanevACVAVTVAMHFLFLV 734
gi 465977034  569 ELTLKTLTFIGCGVSFCALIVTFILFLAVGVpksERTTVHKNLIFALAAGEALLMFSELAKtnqvLCFAVTAFLHLFFMA 648
gi 170285045  715 EWTLRTLTFIGCGVSLCALLVTFILFLAVGVpksERTTVHKNLIFALAAAESLLMFSELAKnnevVCITVTASLHLFFMA 794
gi 528488886  738 DAGLQILSLIGSAVSLCALIFTFILFVAVGVpksDRTTVHKNLMAALIVAQFLLILSDWAAgsqeACWLVTALLHLFFLS 817
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           ## # #        
gi 59797942   735 AFSWMLVEGLLLWRKVVavsmhpgPGMRLYHATGWGVPVGIVAVTLAMLphdyvapgHCWLnVHTNAIWAFVGPVLFVLT 814
gi 465977034  649 AFSWMLVEGLLLWSKVVavnmsedRRMKFYYVTGWGLPVVVVGVTLATSfnkyvadhHCWLnIQTDIIWAFVGPVLFVLT 728
gi 170285045  795 AFAWMLVEGLLLWSKVVavnmsedRRMRFYYITGWGLPIIIVSVTLATSfnkyvadsHCWLnVQTDIIWAFVGPVLFILT 874
gi 528488886  818 SFCWMLVEGLLLWSKVVsvnisedRRMKMYYVLGWGLPVVIVAVTLVATldqykaqqHCWLnLQSSVIWAFAGPVLFVLA 897
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  #         #   #       
gi 59797942   815 ANTCILARVVMITVSSARrrarmlspqpclqqqiwtQIWATVKPVLVLLPVLGLTWLAGILVHLSPAWAYAAVGLNSIQG 894
gi 465977034  729 VNTFVLFRVVMVTVSSARrrskmltpssglekqigiQIWATAKPILVLLPVLGLTWVCGVLVHLSIIWAHVFIVLNSLQG 808
gi 170285045  875 VNTFVLFRVVMVTISSARrrskmltpncslekqigiQVWATAKPIVVLLPVLGLTWLCGVLVHLSVVWAYVFIALNSFQG 954
gi 528488886  898 VNAVVLFRVVLVTVSSARrrakmltpssdsklhtldLTWAATRPVLILLPVLGLTWLCGVLVHLSDVMAYLFITLNAFQG 977
                         250       260
                  ....*....|....*....|...
Feature 1                                
gi 59797942   895 LYIFLVYAACNeEVRSALQRMAE 917
gi 465977034  809 LYIFLVYAIYNsEVRGSSHWVLI 831
gi 170285045  955 LYIFLIYAIYNsEVRNAIQRMKD 977
gi 528488886  978 LYIFLVYAVYNsEVRNAIRRIQE 1000

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap