Conserved Protein Domain Family
7tmB2_GPR133

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cd15256: 7tmB2_GPR133 
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors
GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.
Statistics
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PSSM-Id: 320384
View PSSM: cd15256
Aligned: 4 rows
Threshold Bit Score: 501.762
Threshold Setting Gi: 59797935
Created: 5-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #   #                                            #  ##  #      #      #  
gi 59797935  563 QVALSSISYVGCSLSVLCLVATLVTFAVLSSvstirnqRYHIHANLSFAVLVAQVLLLISFRLEpgttPCQVMAVLLHYF 642
gi 483514884 564 QVALSSITYIGCALSIFCLTITLVTFAVLSSvstirnqRYHIHANLSFAVLVAQILLLTSFQFSpgtlPCKILAILLHFF 643
gi 512811294 672 KVALSSITYIGCSLSIFCLAITLVTFAILSSvstirnqRYHIHANLSFAILVAQILLLISFRFVsgtlPCKIIAILLHFF 751
gi 410922172 537 QVALTAIGYVGCSISIFCLAITLVTFAVLSSvstirnqRYHIHANLSFAILVAEILLLISARFDpgtlPCKIMAILLHFF 616
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ## # #     
gi 59797935  643 FLSAFAWMLVEGLHLYSMVIKVFgsedSKHRYYYGMGWGFPLLICIISLSFAmdsygtsnnCWLslASGAIWAFVAPALF 722
gi 483514884 644 FLSAFAWMLVEGFHLYSMVIKVFgseeSKHLYYYGIGWGCPLVICVISTTSSlnsygendnCWLslENGAIWAFVAPALF 723
gi 512811294 752 FLSAFAWMLVEGLHLYSMVIKVFgseeSKHFYYYGIGWGSSLVICIVSVTSAldsygeranCWLslEKGAIWAFVAPALF 831
gi 410922172 617 FLSAFAWMLVEGLHLYSMVVKVFgsegSKHFYYYGIGWGSPLLICVVSMTSAlhsygevdnCWLslKNGAIWAFVAPAMF 696
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #  #           #   #          
gi 59797935  723 VIVVNIGILIAVTRVISQISADnykihgdpsAFKLTAKAVAVLLPILGTSWVFGVLAVNgcAVVFQYMFATLNSLQGLFI 802
gi 483514884 724 VILVNIGILIAVTRVISRISADnykvhgdanAFKLTAKAVAVLLPILGSSWIFGILAVNthTLVFQYMFAVFNSLQGFFM 803
gi 512811294 832 VIVVNIGILIAVTRIISRISADnykvhrdanAFKLTAKAVAVLLPILGSSWVFGVLAVNeqAIVFQYMFAIFNSLQGFFI 911
gi 410922172 697 VIVVNIGILISVTRIISRIGGEsykvhgdtnTVKLTAKAVAVLLPILGISWIFGILAVNthSLVFLYIFAIFNSLQGFFV 776
                        250       260
                 ....*....|....*....|
Feature 1                            
gi 59797935  803 FLFHCLLNsEVRAAFKHKTK 822
gi 483514884 804 FLFHCLLNsEVRAAFKHKTK 823
gi 512811294 912 FLFHCLLNsEVRAAFKHKTK 931
gi 410922172 777 FLFHCLLNsEVRAAFKHKTK 796

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