Conserved Protein Domain Family
7tmC_RAIG3_GPRC5C

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cd15277: 7tmC_RAIG3_GPRC5C 
retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
Retinoic acid-inducible G-protein-coupled receptors (RAIGs), also referred to as GPCR class C group 5, are a group consisting of four orphan receptors RAIG1 (GPRC5A), RAIG2 (GPRC5B), RAIG3 (GPRC5C), and RAIG4 (GPRC5D). Unlike other members of the class C GPCRs which contain a large N-terminal extracellular domain, RAIGs have a shorter N-terminus. Thus, it is unlikely that RAIGs bind an agonist at its N-terminus domain. Instead, the agonists may bind to the seven-transmembrane domain of these receptors. In addition, RAIG2 and RAIG3 contain a cleavable signal peptide whereas RAIG1 and RAIG4 do not. Although their expression is induced by retinoic acid (vitamin A analog), their biological function is not clearly understood. To date, no ligand is known for the members of RAIG family. Three receptor types (RAIG1-3) are found in vertebrates, while RAIG4 is only present in mammals. They show distinct tissue distribution with RAIG1 being primarily expressed in the lung, RAIG2 in the brain and placenta, RAIG3 in the brain, kidney and liver, and RAIG4 in the skin. The specific function of RAIG3 is unknown; however, this protein may play a role in mediating the effects of retinoic acid on embryogenesis, differentiation, and tumorigenesis through interaction with a G-protein signaling cascade.
Statistics
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PSSM-Id: 320404
View PSSM: cd15277
Aligned: 7 rows
Threshold Bit Score: 352.5
Threshold Setting Gi: 47219097
Created: 2-Feb-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative allosteric modulator binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of human mGluR1 receptor to a negative allosteric modulator FITM (contacts at 4A)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #           ##  ##  #
gi 46396014   48 AWGIVLEAVAGAGIVTTFVLTIILVASLPFvqdtKKRSLLGTQVFFLLGTLGLFCLVFACVVkpdFSTCASRRFLFGVLF 127
gi 148807482  56 AWGIVLQAVTSAGIVSTFILTIVLVASTPFiqnkKKKSLLGTQVFFLLSTLGLFCLVFDMVVkkdFATCASRRFLFGLLF 135
gi 387915166  43 VWGIVLQALSGAGVLSCFVLALVLLASVPFiqegKKKSTVGTQLLFLFGTLGLFCLVFDFVVkmnFATCASRRFLFGLLF 122
gi 449269908  43 AWGIVLEAVASLGVVTSFVLTIVLVASLPFvqdpQKKSLVATQVFFLLGTFGLFCLTFDFIVgpdFSTCTSRRFLFGVLF 122
gi 160773317  46 AWGIILEALAGLGIICSLLLAVIFLALAPSvmrdERKGSLGINFMFLFGVFGLFSLVFAFIIgpnTAVCEVRRFLFGVLF 125
gi 157841250  51 VWGVVVEAFAAAGLVASLILLIVLLASLPFinskNWRSSFGLHTVFLIFTFGLFALTFAFIVgknFATCASRRFLFGVLF 130
gi 47219097   25 VWGIGVEAVAAAGVVTSFVLFIILVASLPFgtdqKRKAMAVLQAGLLTFTLGLFGLTFAFIVgrySTSCAARRFLFGVLF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                    #   
gi 46396014  128 AICFSCLAAHVFALnflarknhgPRGWVIFTVALLLTLVEVIINTEWLIITLVRgsgeggpqgnssagwavasPCAIANM 207
gi 148807482 136 AICFSCLWVHGVSLnylvrrntqPSGWWIFGLAVCLSLVEAIINTEWLIITIVRta---------------nnPCSIGND 200
gi 387915166 123 AVCFSCLLTHALRLnflsrknsgPNGWRVMGLALTLSLVEAIINTEWLVITILRnnatss--------pvlgdPCDIANM 194
gi 449269908 123 GICFSCLLAHAVALnflarrnrgPRGWVTLAVALLLALVEVIINAEWLIITVARregg------------spdPCQLADA 190
gi 160773317 126 ALCFASLVAHSVRLnylalhnhgPGGGLIFLLATGLFLVEAVINAEWLLITNVRhnlpsa--------isighPCNIDNQ 197
gi 157841250 131 AGCFSCLLMQAVRLnilarrnsgPRGWVWCLGALGLWLVEVVINTEWLIITIVRypvnitgt----iapvlaiPCNIANQ 206
gi 47219097  105 AGCLACLMMHGLWLlllg-rlrrPRSWMLCLGALAVWLVEVIINTEWLIITLVRgpagsv--------dtpdfSCSIANL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ##  #                                   #  ##  #   #             ##  #  #   
gi 46396014  208 DFVMALIYVMLLLLGAFLGAWPALCGRYkrWRKHGVFVLLTTATSVAIWVVWIVMYTYGNkqh-nsPTWDDPTLAIALAA 286
gi 148807482 201 DFAMALIYVMFLILAGFITAWPALCGRYghWRKHAIFILLTLFLSISIWIVWIVMYVYGNvqvgkpLYWDDPTLAIALVS 280
gi 387915166 195 DFAMALIYVMVLMALTLVLGFTSQWGSFkhWKKHGVFILVTIWLSVAIWVAWITMYVYGNeal-grEGWDDPTLGIALVA 273
gi 449269908 191 DFVMALIYVMFLLVAAFSTAWPALCGHYrrWHKHSAFILATTGLSMAIWVAWMAMYLYGNqrvgekPVWDDPTLAIALVS 270
gi 160773317 198 DFVTSLVYVMFLILAALIIPCPVLCGHYlpWKRHGKYIVVTAFLSLSIWVIWIVMYLYGNdkl-gqRYWDDPVLAIALVS 276
gi 157841250 207 DFVMALIYVLNLLLAVVVASVPIMAGKHkqWRKDGALILVTGLLSVGIWVAWIVMYVSGNakn-ggPTWDDPTLAIALVS 285
gi 47219097  176 DFVMSLIYVMVLLLAAVLMPFPALAHKP--WRQDAAFILTTGVSSMVIWIAWILMYAHGNqvv-gnPSWDDPTLAVAVVT 252
                        250
                 ....*....|....*....
Feature 1        #                  
gi 46396014  287 NAWAFVLFYVIPEVSQVTK 305
gi 148807482 281 NGWAFIFFYIIPEISQLTK 299
gi 387915166 274 NAWVFLFFYIVPEICQVTK 292
gi 449269908 271 NACTFLLLYIIPEVTHMTR 289
gi 160773317 277 NGWVFIFFYFIPELLEMTR 295
gi 157841250 286 NAWVFLLLHTVPAVCSLSE 304
gi 47219097  253 NAWVFLFFYIVPEICLLTK 271

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