Conserved Protein Domain Family
7tmC_V2R_pheromone

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cd15283: 7tmC_V2R_pheromone 
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronsal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.
Statistics
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PSSM-Id: 320410
View PSSM: cd15283
Aligned: 19 rows
Threshold Bit Score: 360.438
Threshold Setting Gi: 444705453
Created: 10-Feb-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative allosteric modulator binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of human mGluR1 receptor to a negative allosteric modulator FITM (contacts at 4A)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #           ##  ##  #  
gi 110288009 592 PLGTVLVSLAISLSAFSAMILGLFICYRETPiVRANNRNLSYLLLISLKLCFSCSLMFIGqprTVTCVLRQIIFGIVFSI 671
gi 118406878 592 TMGITLLSVALLGSCFTLAVTLIFALKRHTPlVRANNSEISFLILSSLLLCFLCALAFIGrptTWSCGLRHTAFGIAFSL 671
gi 444705453 447 PLGAVLAVCTALLFLLALAILGIFIWHHQTPiVRANNHQLSYLLLSSLAFCFLCPFLFIGhpgPLTCAVRQAAFGVTFTV 526
gi 82174877   92 ILGIILAAFSVAGSLVALSITLVFYKNRTSPiVKANNSELSFLLLFSLTLSFLCALTFIGrptEWSCMLRHTAFGITFVL 171
gi 82267498  483 SLGIALMVTAVVGACTTIAIFAVFFYHRNTPiVRVNNAELSFFILLALVLCFLCSLVFIGeptSWSCMLRHTAFSITFSL 562
gi 358681350 243 PLGAVLAFIAFTFSVSTAIVLAIFIMFRDTPiVKANNRDLSYILLLSLMFCFLCSLLFIGqpqKVTCILRQAVFGIAFTV 322
gi 81870400  456 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPiVKANNRSLSYLLLMSLMFCFLCSFFFIGlpnKVICVLQQITFGIVFTV 535
gi 81865990  590 PLGKGITLLSIGFSTLTALFIWVFVDHRGTPiIKANNRSLSYILLITLILCFLCPLLFIGlpnTATCIMQQYMFGLLFTV 669
gi 81861136  506 PLGKTLCFMSLGFSSLTAAVLVVFLKNRDTPiVKANNLALSYTLLITLMLCFLCPLLFIGrpsTASCILQQNIFGLLFTV 585
gi 512879793 576 ELGMSISFLSIFFFFLTCLVMAVFNIHRTTPiVKANNQNLSYVLLFSLKMCFLCPLIFIGqpiKLTCMTRQTVFSIIFSI 655
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 110288009 672 VISAILAKTFIVVMAFkaikpgsilkmgmvtrlSNAIVCCGSIIQVCICAVWLGTYPPfpdvdmhsefgqiiLWCNEGST 751
gi 118406878 672 CLSCVLGKTLVVLMAFkaslpgsnvmrwfgplqQRGIIFMCTAVQVVICCTWLCVAPPiphmlmthetariiLLCDVGSS 751
gi 444705453 527 CVSTVLAKTIVVVAAFhatrpdawikkwagpvlPSTIPIACSLVQATLCIFWLIGWPPqpvnste-pgstvtVKCDEGSL 605
gi 82174877  172 CISCVLGKTIVVLIAFkatlpgsnvmkwfgplqQRLSVLGFTLVQVLICVLWLKIYPPfpynnmhqykekiiLECSLGSA 251
gi 82267498  563 CFSCILGKTLVVLAAFtatrpgynimkwlgpkqQRAIIFSCTLVQVIICIAWLIEAPPapfrnteyehskviLECSVGSS 642
gi 358681350 323 SVSSILGKTLTVVMAFyatkpgsnirswikfgvGSYLVVFCSIIQGIICFIWLLIAPPypsydsqsvtgqviLECSEGSI 402
gi 81870400  536 AVSTVLAKTVTVVLAFkvtdpgrrlryflvsgtLNYIIPICSLLQCVLCAIWLAVSPPfvdidehsqhghiiIVCNKGSV 615
gi 81865990  670 ALSTVLAKTITVVMAFkitapgrkirwlltsqvPKFAIPICTLIQVLLSGIWLGTSPPfidkdyhsehghiiILCNKGSY 749
gi 81861136  586 ALSTVLAKTITVVIAFkitspgrirrwllisraPNFIIPLCTLLQVFLSGIWLTTSPPfidkdahsehghiiIICNKGSA 665
gi 512879793 656 SLSSILAKTITVVIVFhatkpgnklknlmgskvSVSIVIFCSFVQVVICACWLGISPPfpqynmedevgkiiAECNEGSL 735
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  ##  #                                 #  ##  #   #       ##  #  #   #      
gi 110288009 752 LAFYCVLGYLGFLASLSLLIAFLARRLPdsFNEAKTITFSMLVFCSVWISFVPAYLSskGKTMVAVEILSILASSAGLLG 831
gi 118406878 752 FAFSLVLGYIGLLAAVCFLLAFFARKLPdnFNEAKFITFSMLIFCAVWIAFVPAYISspGKYTVAVEIFAILASSYGLLL 831
gi 444705453 606 ELFHAMLGYLGLLGLVSLLVAFPARRLPdtFNEAKHITLSMLVCSCVWVSFIPAHTSaqGKDTVAVEVFTILASGAGLMS 685
gi 82174877  252 IGLWAVLGYIGLLAFLCFVLAFLARKLPdnFNEAKFITFSMLIFCAVWITFIPSYVSspGKFTVAVEIFAILASSFGLIL 331
gi 82267498  643 VAFWCVLGYIGLQACLSFILAFLARKLPgnFNEAKFITFSMLIFCAVWLAFIPAYVSspGNYSDAVESFAILASSFGLLF 722
gi 358681350 403 MAFYYVLGYIGLLASLCFIIAFLARNLPdsFNEAKFITFSMLVFCSVWVAFIPTYLSskGKYMVAVEIFAILASSAGLLG 482
gi 81870400  616 TAFYCVLGYLACLALGSFTLAFLAKNLPdaFNEAKFLTFSMLVFCSVWVTFLPVYHStkGKHMVAVEIFSILASSAGMLE 695
gi 81865990  750 IYFYCTLAYLGVMAFGSYLLAFLSRRLPdrFNESKSLAFSMLVFCSVWVMFLPVYHStsGKVMVAMEMFSILASSASILI 829
gi 81861136  666 VAFHCNLGYLGALALVSYFMAFLSRNLPdtFNEAKFLAFSMLVFCSVWVTFLPVYHStkGKNMVAMEVFSILASSTSLLG 745
gi 512879793 736 IGFYCVLGYLGVLASVSFIIAFLARDLPdtFNEAKFITFSMLVFCSVWVSFIPAYMSakGKYVVAVEIFAILASSLALLG 815
                        250
                 ....*....|..
Feature 1                    
gi 110288009 832 CIFLPKCYVILL 843
gi 118406878 832 CIFTPKCYIILL 843
gi 444705453 686 CLFFPKCYIILL 697
gi 82174877  332 CIFAPKCFIIVF 343
gi 82267498  723 CMFAPKCYIILL 734
gi 358681350 483 CIFLPKCFVIIL 494
gi 81870400  696 CIFVPKIYIILM 707
gi 81865990  830 IVFAPKCYIVLF 841
gi 81861136  746 IIFAPKCYLILL 757
gi 512879793 816 CIFIPKCYIILV 827

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