Conserved Protein Domain Family
7tmC_TAS1R2

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cd15288: 7tmC_TAS1R2 
type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G protein-coupled receptors
This group represents TAS1R2, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive monosodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.
Statistics
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PSSM-Id: 320415
View PSSM: cd15288
Aligned: 5 rows
Threshold Bit Score: 443.844
Threshold Setting Gi: 465959188
Created: 10-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative allosteric modulator binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of human mGluR1 receptor to a negative allosteric modulator FITM (contacts at 4A)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #           ##  ##  #  
gi 116242831 564 APTIAVALLAALGFLSTLAILVIFWRHFQtpiVRSAGGPMCFLMLTLLLVAYMVVPVYVgppkVSTCLCRQALFPLCFTI 643
gi 465959188 188 GTTVVLLLFSVLGLIATVVISVTFAIHSHtpvVKSAGGRMCFLMLASLIIGFVNVPMYVgiptEFTCVCRQTAFSLCFTV 267
gi 612062884 550 PLTIIVVILATLGFLSTLAILIIFWVHFQtpmVRSAGGRMCFLMLTPLLVAYVSVPVYIgrptVFTCLYRQTLFTLCFTV 629
gi 620957463 104 GPTIVLIIFATLGFLSTLAIMAIFGLHLHtpmVRSAGGKMCFLMLAPLAVGFAFVPVHVgkptEFTCLCRQTVFTLCFTV 183
gi 505780002 560 APTILVATLAALGFLGTLAALLLFGRHVQtpvVRSAGGNMCFLMLVPLLGAYALVPLYVglptVPACLSRQALVPLCLTL 639
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
gi 116242831 644 CISCIAVRSFQIVCAFkmasrfpraysyWVRYQGPYVSMAFITVLKMVIVVIGMLATGlspttrtdpddpkitivscNPN 723
gi 465959188 268 CISCLTVGSFQIVSIFktaawlpkaysyWMKYNGQYIFITVIIALKVTITVTNFIIHPpapvllaqeddpstvalqcNKS 347
gi 612062884 630 CIACINVRSFQIVCIFkmasqlphaysyWVKYNGPYVFVVLITLLKVGIVVSSAMAIPtsptilydnenpqimilncNIN 709
gi 620957463 184 CIACIAVRSFQIVCIFkmarkwprayqcWLKYHGPYAFVALFTTLKVVIIAINVVASNyapttrldpedanvmiltcDPN 263
gi 505780002 640 CISCTAVRSFQIVCVFrvarrlpraygcWVRYHGPYLFVALTVLLKMATVAGSVLSKPtdlsaradpgdpqvlilacNPS 719
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #  ##  #                                 #  ##  #   #       ##  #  #   #    
gi 116242831 724 YRNSLLFNTSLDLLLSVVGFSFAYMGKELPtnYNEAKFITLSMTFYFTSSVSLCTFMSaysGVLVTIVDLLVTVLNLLAI 803
gi 465959188 348 YKLALLMNSSLDMFLSSLCFCFSYMGKELPknYNEAKYITLCMTCYSVSRIAIFLVMSryrGVLVTLCDAMRMVINLLGI 427
gi 612062884 710 SRKAILFNTSLDLILSIFGFSFSYMGKELPtnYNEAKFITLSMTFYFASSAFLCTFMSvyqGVLLTIFDVSITVINLLSI 789
gi 620957463 264 YRHALLSNTGMDLVLSLVGFLFAYMGKELPtnYNEAKFITLNMTFYFTSSVSLCTFMSvyeGVLVTIFDAAVTVVNLLGI 343
gi 505780002 720 YGRGLLANSGLDLLLSVLGFCFAYAGKELPtsYNEAKFITFCMTFYFASSVFLCTLMSvyeGVLVTFLDLLVTVLNLLCF 799
                        250
                 ....*....|....
Feature 1                      
gi 116242831 804 SLGYFGPKCYMILF 817
gi 465959188 428 SLGYFGPKCYLIFF 441
gi 612062884 790 SMGYFGPKCYMILF 803
gi 620957463 344 SLGYFAPKCYMILF 357
gi 505780002 800 TLGFFGPKCHTILF 813

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