Conserved Protein Domain Family
7tmC_TAS1R3

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cd15290: 7tmC_TAS1R3 
type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors
This group represents TAS1R3, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive monosodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.
Statistics
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PSSM-Id: 320417
View PSSM: cd15290
Aligned: 9 rows
Threshold Bit Score: 336.263
Threshold Setting Gi: 348604129
Created: 10-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative allosteric modulator binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of human mGluR1 receptor to a negative allosteric modulator FITM (contacts at 4A)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #           ##  ##  #  
gi 465954543 397 PLVIGLLVLMLFATVLTCLSAVLFLKSLNtplVQACGGTRSIFALLCLFLTCLSFCLHIGkpsVVSCMVQQPFYALGLSA 476
gi 118406880 567 YESIGVILGGIVVLASHVWVGALFFKHRGtplVKTAGGPLCGLTLLSLAGGCMSLVLFLGqpgDTVCRLQEPLNAFFPTV 646
gi 348604129 562 TLTIGLLMLMSIIIFLTCLTAVLFLKNLEtplVQASGGKLSLFALFMLILLCLSSCLYIGkpsNNLCMMQQIVYALCLNA 641
gi 123895155 563 PVSLYLIVAGVILLICQGSVFVLFLMHRGtpvVLASGGALTFATLLSLMGACLSLLLFFGqpgDVVCHIQLPLISIFQTV 642
gi 62299063  567 PAVLLLLLLLSLALGLVLAALGLFVHHRDsplVQASGGPLACFGLVCLGLVCLSVLLFPGqpsPARCLAQQPLSHLPLTG 646
gi 123895151 566 PEALLLTLAIVLVVLFMGSVVVVFVNHREtvlVTASGGTLSIVVLLGLMGACLSLLLFLGqpgDTVCRLQLPLISAFQTV 645
gi 317418847 565 PEALAMMLAVVLLLICQASVGVVFLKHRGtllVKASGGVLSFVAVLSLMGACLSLLLFLGqpgDVVCRLQLPLTSIFQTV 644
gi 573908749 575 YESLGLILGAVLVLAGQAAVGVLFLRHRGtplVQASGGPLCGVALLSLTGGCASLSLFLGkpgDAVCRLQQPFNAFFPAV 654
gi 597775786 570 YESIGLTLAGVLLLVCQAGVSVIFFKHRGtplVSATGGLLCALSLMSLVAGCASLVLFLGqpsDTVCRLQQPLNAIFPTV 649
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 465954543 477 CFSTFLVKSLEIVLLTEFtscpks-sllwvtQKRAWLIVAIACLVESMLCFWYIYSVPaipasnykl--lhaqvligcRI 553
gi 118406880 647 ALSVILSSSLQIVCVTEFleqsse-hlenlrGRGSWFVILGCCGLQAGLCGWYGLEGPsltqyvasldvtyvktflrcPV 725
gi 348604129 642 CFSTFFIKSLEITLVTEFpwcalt-flhwvtQGRAWLLVTLCLFTECLFCFCYLHLGPdymvrdyks--lptevllvcNT 718
gi 123895155 643 ALSVILAVSLQLLLVTEFpksvap-hlrtlrGPGSWVFVLICCLVQAGLCGWFVQDVPslseyknnmt-inflhsflaCP 720
gi 62299063  647 CLSTLFLQAAEIFVESELplswadrlsgclrGPWAWLVVLLAMLVEVALCTWYLVAFPpevvtdwhm--lptealvhcRT 724
gi 123895151 646 PLSIIMSISLQIFFVSEFpnlaas-ylhvlrGPGTWLLLLTCCAVQAGICGWFVQDGPslseyladrrvdfvrsflacPV 724
gi 317418847 645 ALAIITSISLQIFYVSEFpktaas-hlhvlrGPGSWLFVVICCVVHAGICGWYVQEGPslteymanmtinfvrefltcPV 723
gi 573908749 655 ALSIILAISLQVIYVTEFpgvtps-rldslrGPGSWMVVLTLCSVQAGLCGWFVQEGRplseyvsrmritfvetflrcEV 733
gi 597775786 650 TLSTILTISLQIVYVTEFperapv-vlqnlrGPGSWTVVLACCGLQMGLCGWFARDGPsltryvaglevkfltrflacPV 728
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #    #  ##  #                                 #  ##  #   #             ##  #  # 
gi 465954543 554 QSWFAFIMIHGYTGGLAFICFLCTFMVQTPakrYNMARGITFSMLSYFVTWIAFVATYStv------qPTQQPAAQICSG 627
gi 118406880 726 EPMLNFGLMLGFNVILALMSFMSTFMALKPpgqYNLARDITISTLSYCVMWVMFIPIYTsl------dDKNKSLAQVGVS 799
gi 348604129 719 ESWLAFALIHGYNGCLAFVCFLCTFMVQTSgkkYNIARGITFAILIYFIIWIFFIAIFAtl------kTVLRSVTQIGTI 792
gi 123895155 721 VPSEKLAIMQGLNGSMALVSFMCTFMAVKPlhqYNLARDITFSTLIYCVTWVIFIPLYTgfstsqstdHKKRSIAHVSFT 800
gi 62299063  725 RSWVSFGLAHATNATLAFLCFLGTFLVRSQpgcYNRARGLTFAMLAYFITWVSFVPLLAnv------qVVLRPAVQMGAL 798
gi 123895151 725 SPLSGFALMQGFSAAMALMSFMCTFMATKPlhqYNLARDITFSSLIYCVIWVTFIPIYIgl------eEKRRAIIHVSFI 798
gi 317418847 724 EPLSGFALLQGFNSALALISFMCTFMAVKPlhqYNLARDITFSSLIYCVIWVTFIPIYIgl------nVKNRSIVHVSFT 797
gi 573908749 734 EPMVGFGLMYGFNGLLALISFMCTFMAQKPakqYNLARDITFSTLAYCVVWVVFIPIYTgl------gEMNKSLAQMAAI 807
gi 597775786 729 EPVLNFGLMLGFNGVLALISFMCTFMAMKPvrqYNLARDITISSLAYCVTWVIFIPIYAgl------sDKEKSIAQVMVT 802
                        250       260
                 ....*....|....*....|.
Feature 1          #                  
gi 465954543 628 LLCALGLLASYYLPKCYILLF 648
gi 118406880 800 LLSNMGLVAAYFFPKCHLLVK 820
gi 348604129 793 LTCSLGILGTYYIPKCYIILF 813
gi 123895155 801 LVGISALVLAYYLPKCFLLLR 821
gi 62299063  799 LLCVLGILAAFHLPRCYLLMR 819
gi 123895151 799 LASDLGLVAVYYIPKCYFLLK 819
gi 317418847 798 LSSNLGLLAAYYFPKCFLLLR 818
gi 573908749 808 LLSNLGLVAAYFFPKCHLLLT 828
gi 597775786 803 LLSNMALVGTYYGPKCYLLVK 823

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