Conserved Protein Domain Family
7tmA_Histamine_H4R

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cd15295: 7tmA_Histamine_H4R 
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320422
View PSSM: cd15295
Aligned: 4 rows
Threshold Bit Score: 416.533
Threshold Setting Gi: 345317948
Created: 5-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 14194819   16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLf-EWDFGkeICVFWLTTD 94
gi 585692765  16 AVLMFLMSLFALVIMLGNAVVVLAFVVDKNLRHRSNYFLLNLAISDFFVGAISIPLYISYTLd-KWDLEsgLCPFWLIID 94
gi 334325854   9 VILSILMAFLAFSIVLGNGLVIIAFVVDKNLRLRSNFFFLNLAISDFFVGAICIPLYIPYETqgRWDAGnkLCVFWLVID 88
gi 345317948  36 SVLLAVIILLALVTVLGNALVAIAFAVDKNLRHRSNYLFLNLAISDFIVGAISIPLYIPYALtnRWVFGrgLCKFWLVID 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                      #    
gi 14194819   95 YLLCTASVYNIVLISYDRYLSVSNAVsYRTQHtGVLKIVTLMVAVWVLAFLVNGPMILvsesw----kdegsECEPGFFS 170
gi 585692765  95 HLLCTASAYNIVLISYDRYQSVSNAVsYRAKQtKTLWIVTPMMAVWVLAFLVHGPMILvsqsw----ktgqvQCEPRYFS 170
gi 334325854  89 YLLCTTSVYNIVLISYDRYQSVCNAIsYRNKPsSISRTATFMVAVWVLAFMVHGPAILsgskd----qtektECRNQLLF 164
gi 345317948 116 YLSCSASVFNVVLISYDRYQCVSNAVlYRNQQgATARAVIQMAATWILAFVVHGPAIVfwdyvtgvsavedgTCVAEFYS 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #  ##  #                                                                    
gi 14194819  171 EWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRdhlsrcqshpgltavssnicghsfrgrlssrrslsastevpasfhs 250
gi 585692765 171 KQYIIAIISVFEFLVPVILVVYFNIYIYWSLWKReslrrcqshlglnpdtsssnswclfkcglysgtslpelketgapch 250
gi 334325854 165 TDYYIITTSILEFLIPTILVTYFNYCIYWSLHSRsrvrgslvstpnisssvqgnsmtcaffpmvrlpkpdeevpsssv-- 242
gi 345317948 196 NWHFLMCVSVLDFAVPALSVAYFNTQIYRSIRKRsqrsqaedagplpasspanlrvpvrlarflrssllvwrqr------ 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #  ##  #      
gi 14194819  251 -erqrrksslmfssrtkmnsntiaskmgsfsqsdsvalhqrehvelLRARRLAKSLAILLGVFAVCWAPYSLFTIVLsfy 329
gi 585692765 251 peelgrkshllfllrthvnnniftskvwslshsasltphqkehlelLRAQKLAKSLAILVGLFVICWAPYTVSTIFFdak 330
gi 334325854 243 --kkirkkslfasfrtreeeetasaeltslshsnsvpivlraqhelLRDRKIAKSLAIILGAFVFCWAPYILFTIIRfac 320
gi 345317948 270 ------tldsdrredglcrspethsrpfgarslapsqcdtrsryklLRDRKMARSLAIILVTFAICWAPYSLLTIIRaac 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
Feature 1                  #   #   #                          
gi 14194819  330 ssatgpKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFC 374
gi 585692765 331 ----qrQSLWYEIAFWLQWLNSFINPILYPLCHRRFQRAFSKIFC 371
gi 334325854 321 n--qrrDNSWYTFTFWLQWFNSFLNPFLYPLCHKRFRIAFMKIFC 363
gi 345317948 344 e--khkGDPFYNFAFWLLWVNSSINPFLYPLCHKRFRKAFLKVLC 386

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