Conserved Protein Domain Family
7tmA_Histamine_H3R

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cd15296: 7tmA_Histamine_H3R 
histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320423
Aligned: 9 rows
Threshold Bit Score: 444.619
Created: 5-Jul-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                   #   #
Q9JI35        36 AVLAALMALLIVATVLGNALVMLAFVADSSLRtQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGlCKLWLVVD 115 domestic guinea...
KFQ95771      21 ALLAALMGLLVLATVLGNALVILAFVVDRSLRtQGNFFFLNLAIADLLVGGFCIPLYIPYVLTGEWRLGRGlCKLWLVVD 100 crested ibis
CAG10949      31 VILSVLMVTLVVVVVAGNALVIVAFMVDKTLRnQSNYFFLNLAISDFLVGAFCIPVYIPYSLTGRWMLGKGlCKVWLVMD 110 spotted green p...
Q9Y5N1        35 AVLAALMALLIVATVLGNALVMLAFVADSSLRtQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGlCKLWLVVD 114 human
EMP35828     105 IALAALMALLIVATVVGNALVMLAFVVDSSLRtQNNYFLLNLAISDFLVGAFCIPLYVPYVLTGRWAFGKSfCKLWLVID 184 green sea turtle
XP_002939863  27 VFLAVLMGVLIVSTVLGNALVMLAFVVDSSLRtQNNYFLLNLAISDFFVGALCIPLYVPYVLTGRWGFGRSvCKLWLVLD 106 western clawed ...
XP_002931741  56 IILAVLMALMVLATVLGNALVILAFVVEKGLRtQGNFFFLNLAIADFLVGGFCIPLYIPYVLTGQWKFGKGlCKLWLVMD 135 western clawed ...
NP_001020689  65 IFLTVLMTLLVFATVLGNALVILAFVVEKSLRtQGNFFFLNLAIADFLVGGFCIPVYIPYVLTGEWRLGRGlCKLWLVVD 144 zebrafish
ELV09907      43 VLLAVLMALLALATVLGNALVVVAFAVDRSLRsRGNFFFLNLAVADLLVGGFCIPLYIPYVLTGKWKFGKGlCKLWLVTD 122 Chinese tree shrew
Feature 1        #  ##                                                                      #    
Q9JI35       116 YLLCTSSVFNIVLISYDRFLSVTRAvsYRAQQgdTRRAVRKMVLVWVLAFLLYGPAILSWEYlsggssIPEGHCYAEFFY 195 domestic guinea...
KFQ95771     101 YLVCTASVFNIVLISFDRFISVTRAvsYRAQKgmTRNAVLKMITVWIAAFLLYGPAILSWEHiaqksiLPEGECHAEFFY 180 crested ibis
CAG10949     111 YLLCSASVFNIVLISYDRFLSVTRAvkYRVQRnmTRQAVLKMVAVWVLAFLLYGPAIIFWEAmvgqsvVPPHECYAEFYF 190 spotted green p...
Q9Y5N1       115 YLLCTSSAFNIVLISYDRFLSVTRAvsYRAQQgdTRRAVRKMLLVWVLAFLLYGPAILSWEYlsggssIPEGHCYAEFFY 194 human
EMP35828     185 YLLCTSSVFNIVLISYDRFLSVTRAvtYRAQQgnTKQAVLKMVMVWVLAFLLYGPAIISWEYvtgqsiIPDGECYAEFFY 264 green sea turtle
XP_002939863 107 YLLCTSSVFNIVLISYDRFISVTRAvsYRAQQsnSRHAVLKMTMVWILAFLLYGPAIITWEYiaggsiIPDGECFAEFFY 186 western clawed ...
XP_002931741 136 YLLCTASVFNIVLISYDRFISVTKAvsYRAQKgmTRNAVLKMLIVWVAAFLLYGPAIITWEYiarttiLPEGECYVEFYY 215 western clawed ...
NP_001020689 145 YMLCTASVFNIVLISFDRFQSVTKAvsYRCQKgiTKDAVLKMLCVWLAAFLLYGPAIISWEHitggsvVPDGECYAEFYF 224 zebrafish
ELV09907     123 YLVCTASVFNIVLISYDRFLSVTRAvtYRAQKnmTRDAILKMVLVWMAAFLLYGPAIISWEYvakrsiLPRGECYAEFCY 202 Chinese tree shrew
Feature 1            #  ##  #                                                                    
Q9JI35       196 NWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRtrlrldggareagpdplpeaqssppqpppgcwgcwpkgqgesmplh 275 domestic guinea...
KFQ95771     181 NWYFLMIASTIEFFTPFITVTYFNLSIYLNIRKRtslrnenlspgqddcemsfqgkkrehavffvkpanrhkhgkkrass 260 crested ibis
CAG10949     191 TWYFLLSGSIFEFFTPFVSVAFFNLSIYLNIHRRikdggasgddeareqgvskkprdggvwtvffmktrkvscseptais 270 spotted green p...
Q9Y5N1       195 NWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRtrlrldgareaagpepppeaqpspppppgcwgcwqkghgeamplhr 274 human
EMP35828     265 NWYFLMTASTLEFFTPFISVLFFNLSIYLNIQKRtkirldifhevqsqsfmeememspegklslkccqwdqkepgetldl 344 green sea turtle
XP_002939863 187 NWYFLMTASTLEFFTPFISVTYFNVSIYMNIQKRtkarldllqeaqshtntdnikappekarssslkcwklhqkmarfgg 266 western clawed ...
XP_002931741 216 NWYFLMIASTIEFFTPFISVTYFNLSIYINIKRRtmmrneemaqgqehceltfqgkrkehliffvkpadrpygeakkqgg 295 western clawed ...
NP_001020689 225 NWYFLMTASTVEFFTPFISVTYFNLSIYINIRNRcamreeqptyvrlrsfkmkplgagdvqrvffvrpveesrvadlasr 304 zebrafish
ELV09907     203 NWYFLMTASIIEFFTPFISVTYFNLSIYINIQKRtslrnnnfarsqngmemnfqerekkhvffvkpaerngkkrdqgfsl 282 Chinese tree shrew
Feature 1                                                                                        
Q9JI35       276 rygvgeagpgaea-geaalgggsgaaasptsssgsssrgterprslkrgskpsassaslekrmkmvsqsitqRFRLSRDK 354 domestic guinea...
KFQ95771     261 lsppkkasrl------slhkldnqslnlnvnqdlpplqvevetkphrngfyktpeslcnttsrvdiantmanRFRLSRDK 334 crested ibis
CAG10949     271 avie-------------------ddeapsphssrdpnssqllihrenssphgknsrlfqpagagpapdrraqRHRLSRDK 331 spotted green p...
Q9Y5N1       275 ygvgeaavgaeageatlgggggggsvasptsssgsssrgterprslkrgskpsassaslekrmkmvsqsftqRFRLSRDR 354 human
EMP35828     345 pkcetqqga--------anasqsvkdsqisdskssgpfgeksrsfnkrgykhsastislekrmkmvsqsitqRFRLSRDK 416 green sea turtle
XP_002939863 267 sdhqktiklt------esemmervrgmkrnslngstvtamgksrsarrsfnessstpslekkmrvvsqgiaqRFRLSRDK 340 western clawed ...
XP_002931741 296 tlspampsavg-----ngaqelespmldlninqdlpplqvevsakksqdcfyksaenacsnmrpdmassianRFRLSRDK 370 western clawed ...
NP_001020689 305 srccrlastakvsaaefgngrqskrrdstladlpplqveerilaaseaqfhyvdhsagphrhrpdmvaslanRFRLSRDK 384 zebrafish
ELV09907     283 rhqvl-----------------ssevpetqdlpplevdlgtksqqgwqnhcrvsenvcnvlrqpdlsntvasCLQLSRDK 345 Chinese tree shrew
Feature 1                        #  ##  #               #   #   #                     
Q9JI35       355 KVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCvPDYWYETSFWLLWANSAVNPVLYPLCHySFRRAF 423 domestic guinea pig
KFQ95771     335 RVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHCvQYSLYETSFWLLWVNSAINPVLYPLCHmSFRKAF 403 crested ibis
CAG10949     332 KIAKSLAIIVCIFGICWAPYTLLMIIRAACSGRCvADYWYEITFWLLWLNSAINPFLYPLCHsSFRRAF 400 spotted green pufferfish
Q9Y5N1       355 KVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCvPDYWYETSFWLLWANSAVNPVLYPLCHhSFRRAF 423 human
EMP35828     417 KVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCiPHYWYEVSFWLLWINSAVNPVLYPLCHySFRRAF 485 green sea turtle
XP_002939863 341 KVAKSLAVIVCAFGLCWAPYTLLMIIRAACRGHCvPNYWYEASFWLLWVNSAVNPILYPLCHnSFKRAF 409 western clawed frog
XP_002931741 371 RVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGRCvQDYLYEISFWLLWLNSAINPVLYPLCHmSFRKAF 439 western clawed frog
NP_001020689 385 KVAKSLAVIVCVFGLCWAPYTLLMIIRAACHGQCvQHYLYEISFWLLWINSSINPILYPLCHsSFKRAF 453 zebrafish
ELV09907     346 RVAKSLAIIVCVFGLCWAPYTFLMIIRAACHGTCvWHVFYETFFWLLWVNSAINPILYPLCHmSFRKAF 414 Chinese tree shrew

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