Conserved Protein Domain Family
7tmA_D4_dopamine_R

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cd15308: 7tmA_D4_dopamine_R 
D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors
Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.
Statistics
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PSSM-Id: 320434
View PSSM: cd15308
Aligned: 5 rows
Threshold Bit Score: 356.838
Threshold Setting Gi: 1345939
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human dopamine D3 receptor in complex with a D2/D3 selective antagonist (eticlopride).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                    #   
gi 109104872  31 AAALVGGVLLIGAVLAGNSLVCVSVATERALqtpTNSFIVSLAAADLLLALLVLPLFVYSEVqggaWLLSprlCDALMAM 110
gi 1345939    35 AAALVGGVLLIGAVLAGNSLVCVSVATERALqtpTNSFIVSLAAADLLLALLVLPLFVYSEVqggaWLLSprlCDALMAM 114
gi 58618089   19 YLALICGVPLILIIILGNVLVCLSVLTERSLktaTNYFIVSLAVADLLLAILVLPLYVYSEFlggiWTLSmyvCDALMTM 98
gi 512835451  63 FLALVFGFILIVCIICGNVLVCLSVCTEKALkttTNYFIVSLAVADLLLAVLVLPLYVYTEFvggvWTLSlvlCDVLMTM 142
gi 210076718  29 IAALVLGIVLILLIVGGNGLVCLSVCTERALkttTNYFIVSLAVADLLLALLVLPLYVYSEFqggvWSLStvlCDALMTM 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                                                         # 
gi 109104872 111 DVMLCTASIFNLCAISVDRFVAVAVPLRYNRqggSHRQLLLIGATWLLSAAVAAPVLCGLNDVrgRDPAVCRLEDRDYVV 190
gi 1345939   115 DVMLCTASIFNLCAISVDRFVAVAVPLRYNRqggSRRQLLLIGATWLLSAAVAAPVLCGLNDVrgRDPAVCRLEDRDYVV 194
gi 58618089   99 DVMLCTASILNLCAISVDRYIAVVVPLKYNRnqfSVRQLALITATWVLSLGVASPVIFGLNQVpnRNPHVCKLEDNQFVV 178
gi 512835451 143 DVMLCTASIFNLCAISVDRFIAVSIPLNYNRrqvDNRQLFLISTTWIFAFAVASPVIFGLNNVadRDPTMCKLEDNNYIV 222
gi 210076718 109 DVMLCTASIFNLCAISVDRFIAVSVPLNYNRrqiDLRQLILISTTWIFAFAVASPVIFGLNNVpnRDPSLCQLEDDNYIV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##                                                                             
gi 109104872 191 YSSVCSFFLPCPLMLLLYWATFRGLrrwevarraklhgraprrpsgpgppslvprlpqdpcgpdcappaprlpqdpcgpd 270
gi 1345939   195 YSSVCSFFLPCPLMLLLYWATFRGLqrwevarraklhgraprrpsgpgppsptppaprlpqdpcgpdcappapglprgpc 274
gi 58618089  179 YSSVCSFFVPCPVMLFLYYWMFRGLkrwssgrnrshlrrpprgrrslslrlgaalqkekgrarekvvylmpaglsptslt 258
gi 512835451 223 YSSVCSFFIPCPIMLVLYCAMFHGLrkweetrktklrshmspglkppqcpallldrsptdskldelnl------------ 290
gi 210076718 189 YSSICSFFIPCPVMLVLYCAMFQGLkrweearkaklrggiyggnrmlyhpspfierervgmepeeyh------------- 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 109104872 271 cappapgppqg-----------------------------------pcgpdrappapglpqglrgpncappvpglppdsc 315
gi 1345939   275 gpdcapaapglppdpcgpdcappapglpqdpcgpdcappapglprgpcgpdcappapglpqdpcgpdcappapglppdpc 354
gi 58618089  259 atpttpisstsp---------------------------------vtlttddlaegqmpgaesdpmttqmdsvsdaenpe 305
gi 512835451 291 ---------------------------------------------------------------------ydqgdcpfpks 301
gi 210076718 256 ----------------------------------------------------------------------pyahpehpls 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               ##  #               #   #
gi 109104872 316 dsncappdavraaalppqtppqtrrrrrakitGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCpaCSVPPRLVSAVT 395
gi 1345939   355 gsncappdavraaalppqtppqtrrrrrakitGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCpaCSVPPRLVSAVT 434
gi 58618089  306 rateddsgrengvgknhrphtgrrhsksnrvsGRERKAMKVLPVVVGVFLACWTPFFVVHVTKALCesCDIGPTLISVVT 385
gi 512835451 302 yvdnghgiqtvayphlkystnmeperkqakinGRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCesCYIPEQLISIVT 381
gi 210076718 266 gdyvmsnglqtvsyphlkyphpahgqkrakinGRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCksCTIPTQVTSIVT 345
                        410       420
                 ....*....|....*....|....*
Feature 1           #                     
gi 109104872 396 WLGYVNSALNPVIYTVFNaEFRNVF 420
gi 1345939   435 WLGYVNSALNPVIYTVFNaEFRNVF 459
gi 58618089  386 WLGYVNSAVNPIIYTAFNvEFRNVF 410
gi 512835451 382 WLGYVNSALNPVIYTIFNtEFRNYF 406
gi 210076718 346 WLGYVNSAVNPIIYTVFNaEFRNFF 370

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