Conserved Protein Domain Family
7tmA_TAAR2_3_4

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cd15312: 7tmA_TAAR2_3_4 
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320437
View PSSM: cd15312
Aligned: 13 rows
Threshold Bit Score: 447.571
Threshold Setting Gi: 301613736
Created: 20-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 82592527   44 VAMYSFMAGSIFITIFGNLAMIISISYFKQLHtpTNFLILSMAITDFLLGFTIMPYSMIRSVenCWYFGltfCKIYYSFD 123
gi 483524834  32 GVLYLFMTAAFLLTISGNLAIIVSISYFKQLQspTNFLILSMAATDFLLGFAIMPYSMVRSVenCWYFGmafCKVHYSFD 111
gi 38257784   32 GDNVFGYDWSHDYPLFGNLVIMVSISHFKQLHspTNFLILSMATTDFLLGFVIMPYSIMRSVesCWYFGdgfCKFHTSFD 111
gi 130507762  35 VTMYAFMVLMILTTVFGNLLIIISISHFKQLQspTHLIVRSLAASDCLLGSLVMPYSMVRSVegCWYLGdvvCKVHSSLD 114
gi 81909985   34 CAMYLIMIGAIVMTMLGNMAVIISIAHFKQLHspTNFLILSMATTDFLLSCVVMPFSMIRSIesCWYFGdlfCKVHSCCD 113
gi 557026947  34 VIMYVFFSGSILVTVFGNLVVIISISHFKQLHspTNFLLLSLAVTDFLVGFIVMPYSMITSIetCWYFGdvfCKIHSSCD 113
gi 591375263  34 WVMYSFMVGAIVLTMGGNMLVIISIAHFKQLHspTNFLICSMATTDFLLSFMVMPYSMIRSVesCWYFGdlfCKLHTCCD 113
gi 557023587  34 MVMYIFMSGAIIITMIGNLLVIISISHFKQLQspTNFLLLSLAIADFLLGFGIMPYSMIRSIesCWYFGeslCKIHSGFD 113
gi 597794551  31 GAMYGFMLVAILMTVFGNLLVIFSISHFKQLQspTNFIILSMALVDCLLGCLVMPFSMVRWVegCWFLGdffCQIHSSLD 110
gi 573876532  23 VAMYIFMVGTMLATVSGNLMVIISIAHFKQLHspTNFLTLSLGCADCLLGAFVMPYSMVRSVetCWYFGdlfCKIHSSLD 102
gi 573876534  32 VAMYVFMAGTIFVAVCGNCMVIISISHFKQLHspSNFLILSLGCVDCLLGSLIMPYSMIRSVesCWYFGeifCAIHSSLD 111
gi 512844684  23 SAMFIVMAGAIVLTTIGNLMVIISVSHFKQLHspTNFLILSLAITDCLLGLVIMPYSMVRSLtsCWYFGdlfCRLHSCLD 102
gi 301613736  45 SALLLFMLGAIIFTTVGNLMVIISVSHFKQLQtpTNVLVMSLAIADFLLGLLVMPYSMVRSLtsCWYFGevfCKLHSCID 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                          #
gi 82592527  124 LMLSITSIFHLCSVAIDRFYAICYPlLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGiegydilvaCSSSCPV 203
gi 483524834 112 LMLCLVSIFHLCSIAVDRFYAICHPlHYAYLMTMNAIKQIIAVCWSAPAAFAFGVVFSEAYASGiegyenlvkCSSLCPV 191
gi 38257784  112 MMLRLTSIFHLCSIAIDRFYAVCYPlHYTTKMTNSTIKQLLAFCWSVPALFSFGLVLSEADVSGmqsykilvaCFNFCAL 191
gi 130507762 115 MTFSISSLIHLSLVSVDRYWAICDPlRYRMRVTNNTVIVFTVFTWLFSFVYSFSVVFSGVNRIGletfimqvyCVGSCVL 194
gi 81909985  114 IMLCTTSIFHLCFISVDRHYAVCDPlHYVTQITTRVVGVFLLISWSVPIFFAFGLVFSELNLIGaedfvaaidCTGLCVL 193
gi 557026947 114 VMLTTASIFHLCFIAIDRYYAVCDPlHYTTTVTIPVILLFLVISWAAPICFAFGMVFSGVNLEGiedlvalifCEGSCIL 193
gi 591375263 114 IMLCTTSIFHLCFISVDRYYAVCDPlHYVTKITVPVIGLFLLISWSVPFLLAFGLVFSELNIDGieeyaasidCSDFCAF 193
gi 557023587 114 MMLSTASTFHLCFIAVDRYCAVCDPlHYSVRITIPVVILFLVISWLVPICFAFGVMFIDSHAEGiedfvdsvsCTGFCAV 193
gi 597794551 111 MTLSIASILHLCLVSVDRYMAICDPlSYRMKVTNGSVAVWIVVTWLFSCLFSFGIVFSKVNLIGldeq-mlnsCVGNCVL 189
gi 573876532 103 MTISVASILHLTFIAVDRYVAICDPlRYRSKITTFVVAIFIGISWIYSLGLGFGVVFSKINLTGieefvilnsCVGTCFL 182
gi 573876534 112 MMMSIASILHLGFIAADRYFAICDPlRYRNKMTMFNITLFIVISWLFSFAFGFGVVLSKVNLAGieefvvsssCVGACIV 191
gi 512844684 103 MTLSTTSIFHLFFISVDRYYAVCQPlHYCRNITTNVILVFICISWAFSCLYSSGLVFSNVHTEGiqnylatfaCTGSCSL 182
gi 301613736 125 MMLSTTSIFHLFFISVDRYYAVCQPlHYYKNITTSVIEVFVFISWCLPCIYSFGLFFSNVDTEGtqdi--gifCTGSCFI 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  ##  #                                                                 #
gi 82592527  204 mFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSrkhahainn--------lrenqnnqvKKDKKAAKTLGIVIGVFLLCW 275
gi 483524834 192 mFNKVWGAVLFTVGLFAPACVMIGIYCKIFLVSqkhvcelsqahk--htksdmknelskSKDRKAARTLSVVMLGFLICW 269
gi 38257784  192 tFNKFWGTILFTTCFFTPGSIMVGIYGKIFIVSkqharvishvpe--ntkgavkkhlskKKDRKAAKTLGIVMGVFLACW 269
gi 130507762 195 fFNKQWGLICSLLTFFLPCTIMSSLYMKIFHVArkhakvmserv-----tgglksqssaQREGKAAKTLAIVMGVFYLCW 269
gi 81909985  194 iFNKLWGVLASFIAFFLPGTVMVGIYIHIFTVAqkharqigtgprtkqalseskmkatsKKESKATKTLSIVMGVFVLCW 273
gi 557026947 194 lFNKLWGTLGLVIAFFIPCTVMIGIYVKIFFVArrhakvlnsmtekmaskgenkkkisgNKERKAAKTLGIVMGVFLLCW 273
gi 591375263 194 iFNKLWGVLGSLIAFFFPGTVMVGIYVHIFTVArkharqmdnipstikyasamtnkistKKENKATKTLSIVMGVFLFCW 273
gi 557023587 194 fLNKLWGVLAPIIAFFSPALIMIGIYAKIFFVArrhavvinntidkvnfvkdiknkiskNKETKAAKTLSIVMGVFLLCW 273
gi 597794551 190 iFNKEWGVIAPLLNFYIPGTIMSCLYLKIFHVArkqakmisdrta--vglageknqvseQRERKAAKTLGIVMGVFLLCW 267
gi 573876532 183 iFNKHWGVLAALLAFLIPGTVMISLYVKIFMVAsrhvrvlndtsgkicarndhkrkiveNRERKAAKTLGIVMGVFLICW 262
gi 573876534 192 iLNKEWGMLSASVAFIIPGTVMISLYIKIFFVArrharvinaaa-----pvddkssiadKREKKAAKTLGIVIGVFLLCW 266
gi 512844684 183 aFNKIWAVITSALCFFMPGTMMIGIYIHIFSVAskqaklvrnqqn--vhpdkaknklsfRAESKAAKALSIVMGVFLFCW 260
gi 301613736 203 lLDKLWGTISSLISFYIPGNFIIGIYIYIFSVAkkqakivhhypstqdqkpnsriklslTIETKAAKTLSIVMGTFLLCW 282
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1          ##  #              #   #   #                     
gi 82592527  276 FPCFFTILLDPFlnfstPVVLFDALTWFGYFNSTCNPLIYGFFYpwFRRAL 326
gi 483524834 270 FPCFFAILIDPFlnfstPVSLFDALTWLGYLNSLCNPLIYGFFYpwFRKAF 320
gi 38257784  270 LPCFLAVLIDPYldystPILILDLLVWLRYFNSTCNPLIHGFFNpwFQKAF 320
gi 130507762 270 LPFFTATAVDPFlnfstPVHVFDALVWFGYFNSTCNPLIYGFFYprFQKAF 320
gi 81909985  274 LPFFVLTITDPFidfttPEDLYNVFLWLGYFNSTFNPIIYGMFYpwFRKAL 324
gi 557026947 274 LPFFTTIIVDPFldfstPGIVFECLVWLGFFNSTFNPIIYGFFYpwFQKAL 324
gi 591375263 274 LPFFILTIADPFinfstPEDLYNAFLWLGYFNSTCNPIIYGLFYswFCKAF 324
gi 557023587 274 LPFMVISVVDPFlnfstPAVLFDAFMWLGYFNSMFNPIIYGFFYpwFRKAL 324
gi 597794551 268 LPFFLTTVIDPFlgfstPVDVFDALIWFGYFNSMFNPLIYGFFYprFQKAF 318
gi 573876532 263 LPFFMATIIDPFigfstPVILFDALVWFGYFNSTCNPVIYGFFYpwFQKAF 313
gi 573876534 267 LPFFITIIIDPFidfstPVIVFDTLMWLGYFNSACNPMIYGFFYpwFQKAF 317
gi 512844684 261 LPFFIVTLVDPYtdfsaSEDVYNTVLWFGYLNSAINPIIYALFYpwFKRSC 311
gi 301613736 283 LPFSVVALFDPYfnfasANGIYDIVLWLGYINSTLNPMIYAFFYpwFRKCF 333

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