Conserved Protein Domain Family
7tmA_TAAR1

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cd15314: 7tmA_TAAR1 
trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320438
View PSSM: cd15314
Aligned: 30 rows
Threshold Bit Score: 387.752
Threshold Setting Gi: 47191525
Created: 28-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 38258636   24 ASLYSLMVLIILTTLVGNLIVIVSISHFKQlhtpTNWLIHSMATVDFLLGCLVMPYSMVRSAehCWYFGevfCKIHTSTD 103
gi 130501796  23 VPMLIAIMLIISMTFIGNLLVIISIGHFRQlhtpTNQLILSLALCDFLIGLFVMPLSAVRSMqgCWYFGeflCKLHTCID 102
gi 131888587  35 APLYLLFIIAIILIVFGNLWVICTISFFQQlhtpTNYLILSMAVSDLLLGSFVMPPSMLRSLetCWYFGdffCKFHSATD 114
gi 465973749  23 MSMYSLMVCIILATLAGNLTVIISIAHFKQlhtpTNFLILSMSTVDFLLGCFIMPYSMVRSVenCWYFGelfCKIHTSTD 102
gi 573876507  34 SPLYLIFVAVILFTVCGNLFVIISIAHFKQlhtpTNFLVLSLAVADLLLGGFIMPPSMVRSLetCWYYGdlfCKIHSSTD 113
gi 557021314  34 IPMYIFMLSTISVTICGNLVVIVSIAHFRQlhtpTNYLILSLATVDFLLAIFVMPYSMVRSVetCWYFGdlfCKIHSSID 113
gi 301612712  25 IPMYVFMVSTILATVVGNLAVIISIAHFKQlhtpTNYLILSMSTVDFLLGSCVMPYSMVRSVenCWYFGdlfCKVHTSTD 104
gi 557021320  32 IPIYAAIGGTILITVCGNLVVIISIAHFKQlhtpTNFLVMSMAVVDLLLGSMVMPYSMVRSVenCWYFGdifCKVHSSTD 111
gi 632962614  34 ITLYLLAVLAILVTLFGNMLVIISIAHFKQlhtpTNYLVFSLAIADFLLGCIVMPYSLIRSIesCWYFGilfCKLHTSFD 113
gi 597794545  34 VPLYILFALIVFLIVSGNLLVICIILLSQHlqmaTNCLILSLSVAGLLLGGLVLPPSMVRSLetCWYFGehfCDFHSTAD 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                           
gi 38258636  104 IMLSSASIFHLSFISIDRYYAVCDPlrYKAKMnILVICVMIFISWSVPAVFAFGMIFLElnfkgaeeiyykhvhCRGGCS 183
gi 130501796 103 ITLSTSSIFHLVSVSAERFCAVCGPlrYRSCFgLSTVLLMISISWLIPGIFAYVMTFLEinihggkdfydahvrCVGGCH 182
gi 131888587 115 FTLCNASVLHLVFISIDRYYAVCQPfhYQSRMtTRVSVFMILISWSFSAFFGFGIIFSElkiekkr-teelhvaCKGGCL 193
gi 465973749 103 IMLSTASIFHLSFISIDRYCAVCDPlrYKSKInTCIIVVMIVISWTVPAIFAFGMIFLElnlkgaeeifynhihCVGGCF 182
gi 573876507 114 VMLSTTSILHLSFISIDRYYAVCEPlkYKTKItVCVALYMVIISWAVSAVIGFGMIFLElnikgmedtyynrfdCVGGCV 193
gi 557021314 114 IMLSTASIFHLSFISIDRYYAVCDPlrYKTKItAFVTLIMISMSWIVSAVFAFGMIFLDlnikgdedfyyqyvvCAGGCI 193
gi 301612712 105 IMLSTSSIFHLSFISVDRYFAVCDPlrYKTKMnVFSVSLMIVTSWVVPTIFAFTMVFLElnikgtesyyynqvsCFGGCA 184
gi 557021320 112 MMLCTASILHLCFVAVDRYYAVCNPlqYKAKItGFVVMMMITISWMLPAVVSFAVIFLGlhmkgveefynnhtkCTGGCV 191
gi 632962614 114 LVLCAASIIHLCCISVDRYYAVCDPlkYKTTItVSTVLIMICLSWALSFLVGFVIIFLElhlieikdfyyheiaCFGGCT 193
gi 597794545 114 IILCNTTVWHLTFISVDRYLAVCHPvhYQNRViKRLYIVMILTSWGLSSVFGFAITLSNpevlik---ddpqktCIGECL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #      #  ##  #                                                                 
gi 38258636  184 VffSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAkeqarlisdanqk--lqiglemkngisqSKERKAVKTLGIVMGVFL 261
gi 130501796 183 VffSHGPAVFTSVFSFYIPGFIIVVIYSRIYMVArnqersirlqln----qlrrvypsrdvqLQTRKATVTIAIVVGAFL 258
gi 131888587 194 AlhGREIGVTYSLVFYFLPMFIIVSLYSRVFIIAlkhvrvins-----------aasslsatKMDLKATKTLAIIIGVFM 262
gi 465973749 183 VffSETSGVVASMISFYIPAFVMLCIYGKIYAIAkrqarsikdaasq--tqirfemkhhispSRERKAAKTLGIVMGVFL 260
gi 573876507 194 LiqSEASSTISSTLSFDIPGFMMVGIYFKIFLVArrqartiqgivsq--sktsedgktmtssKTERKAAKTLGIVMGVFL 271
gi 557021314 194 VffTKTSGVVASLFSFYIPGVIMVCIYGKIYLVArdqarsiedvev----qtaeqnrgrvskKRERKAAKTLGIVVGVFL 269
gi 301612712 185 VffSQTSGLVASMVSFYIPGFVMLCVYGKIYVIArrqarsikdsanqmpfqitlgvnqhvsrSRDRKAAKTLGIIMGVFL 264
gi 557021320 192 LflNEASLVFGSMISFYVPGVIMVCIYGKIYLIAskqaraikgvan----kakeasrsrisrNRERKAAKTLGIVMGDFL 267
gi 632962614 194 LmmGKVCALVYSTISFYFPAFIMVCIYTKIYLVAkkqartinnlsrk--vqpinegnsiasqRSERKAAKTLGIVMGVFI 271
gi 597794545 191 AlhTKEIGVEYSIIFFFMPVSIIVSVYSKVYCVAqrhsraihsy---------ahnpkamptSKDLKATKTLGIVIGNFL 261
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1          #  ##  #              #   #   #                     
gi 38258636  262 ICWCPFFICTVMDpflhyiiPPTLNDVLIWFGYLNSTFNPMVYAFFYpwFRKAL 315
gi 130501796 259 VCWTPFFLCNILNpfigyatPPMLIDVLMWFGYANSTLNPFIYAFMHswCRKAV 312
gi 131888587 263 SCWTPYFMCNIIDpivnhtiPALLYEVLMWVAYLNAVFNPLVYAFFYswFRDKS 316
gi 465973749 261 ICWSPFFFCTATDpfmnystPPILIDALMWFGYLNSTFNPLVYAFFYmwFRRAL 314
gi 573876507 272 SCWTPFFLCNIMDpifnysiPPVLLDTLVWLGYLNSTFNPLVYAFFYnwFRKAL 325
gi 557021314 270 FCWSPFFVCNLMDpflnyktPSLLFDALIWFGYLNSACNPIVYGFFYtwFQKAL 323
gi 301612712 265 ICWTPFFFCTATDgfinyviPPIVIDAFVWIGYLNSTFNPMVYAFFYlwFQRAL 318
gi 557021320 268 LCWFPYLFCNIMDpflnyrtPPVLFEVLVWFAYLNSTFNPIMYGFFYiwFREAL 321
gi 632962614 272 LCWSPYFVCDSIEpfikystPPVLFDAFFWVGYLNSTFNPMIYGFFYswFRKAL 325
gi 597794545 262 FCWTPFFMCNIMDpilnhsiPSVLYEVLMWFSYLNSLFNPLIYAFFYrwFRETA 315

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