Conserved Protein Domain Family
7tmA_TAAR6_8_9

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cd15316: 7tmA_TAAR6_8_9 
trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors
Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320439
View PSSM: cd15316
Aligned: 4 rows
Threshold Bit Score: 470.881
Threshold Setting Gi: 465973748
Created: 20-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 38258634   33 VILYIVFGFGAVLAVFGNLLVMISILHFKQlhspTNFLVASLACADFLVGVTVMPFSMVRTVesCWYFGrsfCTFHTCCD 112
gi 38258635   33 SILYAVLGFGAVLAAFGNLLVMIAILHFKQlhtpTNFLIASLACADFLVGVTVMPFSTVRSVesCWYFGdsyCKFHTCFD 112
gi 38258876   32 VILYTAFSFGSLLAVFGNLLVMTSVLHFKQlhspTNFLIASLACADFLVGVTVMLFSMVRTVesCWYFGakfCTLHSCCD 111
gi 465973748  33 VSLYIVLGLLVIFTVGGNLMVVVSIVYFKQlhspTHFLIASLACADFGLGLTVLPFSTVRSVetCWYFGeifCRFHYCLD 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                          #
gi 38258634  113 VAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFtVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEElsdalnCIGGCQT 192
gi 38258635  113 TSFCFASLFHLCCISVDRYIAVTDPLTYPTKFtVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEElvvaltCVGGCQA 192
gi 38258876  112 VAFCYSSVLHLCFICIDRYIVVTDPLVYATKFtVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEElvsalnCVGGCQI 191
gi 465973748 113 VSLCQASIFHLCFISVDRYVAVNNPLIYPIKFtVPVSGMFIAVAWIFSLVISFSVVFTGSNDKEMQElvnglsCAGSCQI 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ##  #                                                                 # 
gi 38258634  193 vVNQNWVLTDFLSFFIPTFIMIILYGNIFLVArrqakkientgsktesssesykarvaRRERKAAKTLGVTVVAFMISWL 272
gi 38258635  193 pLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAkhqarkiestasqaqsssesykervaKRERKAAKTLGIAMAAFLVSWL 272
gi 38258876  192 iVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAkqqaikiettsskvesssesykirvaKRERKAAKTLGVTVLAFVISWL 271
gi 465973748 193 iLNKMWVVVSSLLYFIPFFAMIMLYGRIFAVAkqqvrmiemmsnn-tqssnnysdrvgRRERKAAKTLGIPVIAFLVFWS 271
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #              #   #   #                     
gi 38258634  273 PYSIDSLIDafmgfitPACIYEICCWCAYYNSAMNPLIYALFYPWFRKAI 322
gi 38258635  273 PYLVDAVIDaymnfitPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAI 322
gi 38258876  272 PYTVDILIDafmgfltPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAI 321
gi 465973748 272 PYLIIVTIDaflnfiiPPLIFDIAIWFAYSNSAINPLIYSVFYPWFRKAM 321

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