Conserved Protein Domain Family
7tmA_D1B_dopamine_R

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cd15319: 7tmA_D1B_dopamine_R 
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.
Statistics
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PSSM-Id: 320442
View PSSM: cd15319
Aligned: 4 rows
Threshold Bit Score: 589.62
Threshold Setting Gi: 118214
Created: 20-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 118214     41 VVTACLLTLLIIWTLLGNVLVCAAIVRSRHlraNMTNVFIVSLAVSDLFVALLVMPWKAVAEVaGYWPFGaFCDVWVAFD 120
gi 449501265 202 VAAGSLLALLILWTLFGNVLVCAAIVRYRHlrsKVTNIFIVSLAVSDLLVALLVMPWKAVAEVaGYWPFGaFCNVWVAFD 281
gi 1169230    42 IVTGSLLLLLIFWTLFGNILVCTAVMRFRHlrsRVTNIFIVSLAVSDLLVALLVMPWKAVAEVaGHWPFGaFCDIWVAFD 121
gi 542221292  45 TVTGCLLSLLILWTLLGNILVCSAVLRFRHlrtKVTNIFIVSLALSDLFVAVLVMPWKAVAEVaGYWPFGtFCNVWVAFD 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                           
gi 118214    121 IMCSTASILNLCVISVDRYWAISRPFRYKRKMtQRMALVMVGLAWTLSILISFIPVQLNWHrdqaaswggldlpnnlanw 200
gi 449501265 282 IMCSTASILNLCVISVDRYWAISSPFRYERKMtQRLALVMISVAWALSVLISFIPVQLNWHkdmsttwvalaavrps--- 358
gi 1169230   122 IMCSTASILNLCVISVDRYWAISSPFRYERKMtQRVALLMISTAWALSVLISFIPVQLSWHksetedhl----------- 190
gi 542221292 125 IMCSTASILNLCIISVDRYWAISSPFRYERKMtQRVAFVMISVTWTLSVLISFIPVQLNWHkasgddmvgah-------- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #      #  ##  #                                               
gi 118214    201 tpweedfwepdvnaeNCDSSlNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQirRISSLERAAEHAQSCRssaac-- 278
gi 449501265 359 dgtsgsndtlsgpseSCDSSlNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQirRISSLERAAEHAQSCRsshid-- 436
gi 1169230   191 --------lsnhstgNCDSSlNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQikRISTLERAAEHAQSCRsnrvdsc 262
gi 542221292 197 -----nssisrqveeNCDSSlSREYAISSSLISFYIPVAIMIVTYTRIYRIAQIQirRIASLERAAEHAQSCRtnrie-- 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #  ##  #                        #   #   #       
gi 118214    279 --apdtSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCsghpegppagfPCVSETTFDVFVWFGWANSSLNP 356
gi 449501265 437 -chhhtSLKSSIRKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCesppsdphaglPCVSETTFNIFVWFGWANSSLNP 515
gi 1169230   263 srhhqtSLRTSIKKETKVLKTLSIIMGVFVCCWLPFFILNCMVPFCdrspghpqaglPCVSETTFDIFVWFGWANSSLNP 342
gi 542221292 270 -cqhhnTLKTSIKRETKVFKTLSVIMGVFVCCWLPFFVLNCMVPFCdrpaadrdaglPCVSETTFDVFVWFGWTNSSLNP 348
                        330
                 ....*....|...
Feature 1                     
gi 118214    357 VIYAFNADFQKVF 369
gi 449501265 516 IIYAFNADFRKVF 528
gi 1169230   343 IIYAFNADFRKVF 355
gi 542221292 349 IIYAFNAEFRKAF 361

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