Conserved Protein Domain Family
7tmA_alpha2A_AR

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cd15322: 7tmA_alpha2A_AR 
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.
Statistics
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PSSM-Id: 320445
Aligned: 4 rows
Threshold Bit Score: 425.127
Created: 8-Jul-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                   #   #
P08913        34 LTLVCLAGLLMLLTVFGNVLVIIAVFTSRAlkapQNLFLVSLASADILVATLVIPFSLANEVmgyWYFGkaWCEIYLALD 113 human
NP_001072843  47 LALITLVGMLMLFTVFGNVLVIIAVFTSRAlkapQNLFLVSLASADILVATLVIPFSLSNEVmgyWYFGkvWCEIYLALD 126 western clawed ...
Q90WY4        23 LPLSIAVGLLILLIIFGNVLVIIAVFTSRAlrapQNLFLVSLASADILVATLVMPFSLANELmgmWTFGgvWCEIYLALD 102 zebrafish
EOB05122      27 VTLISLAGLLMLFTVFGNVLVIIAVFTSRAlkapQNLFLVSLASADILVATLVIPFSLANEVmgyWYFGkvWCEIYLALD 106 mallard
Feature 1        #  ##                                                                       #   
P08913       114 VLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKAIIITVWVISAVISFPPLISIekkgggggpqpaepRCEINdQ 193 human
NP_001072843 127 VLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekesg----kvempICKINdE 202 western clawed ...
Q90WY4       103 VLFCTASITHLCAISLDRYWSITQAiEYNLKRTPQRIKRIIFIVWIIAAVISCPPLITMkks--------egdICDINkE 174 zebrafish
EOB05122     107 VLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKCIIFIVWVISAVISFPPLISIekksgqq-tdqgvaLCKINdE 185 mallard
Feature 1           #  ##  #                                                                     
P08913       194 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdavaappggterrpnglgpersagpggaeaeplptql 273 human
NP_001072843 203 KWYIIYSSIGSFFAPCVIMVLVYIRIYQIAKkrtrvppgkrsnaaevgakqhnglaekdlpvklngdkaggsggdhgkev 282 western clawed ...
Q90WY4       175 KWYIVSSCIGSFFLPCIIMVLVYIRIYQIAKkrtrappgdhrknevgkkendpheklngiqnaepddkdeingvdmeess 254 zebrafish
EOB05122     186 KWYIISSSIGSFFAPCLIMILVYVRIYQIAKrrtrvppnkraerpekkqngladkedlpataqlngekaagggdgqegev 265 mallard
Feature 1                                                                                        
P08913       274 ngapgepapagprdtdaldleessssdhaerppgprrpergprgkgkarasqvkpgdslprrgpgatgigtpaagpgeer 353 human
NP_001072843 283 eangvdmdd---------------------------ssssehqednqyqarkkqdklprgkgktklsqikpgdslprree 335 western clawed ...
Q90WY4       255 --------------------------------------------ssdhkvsnpcslkkksskgktklsqikpgdgdktea 290 zebrafish
EOB05122     266 ngidmee-------------------------------tsssehqdnnqskkserpsrgkaktklsqikpgdslprkvee 314 mallard
Feature 1                                         #  ##  #               #   #   #               
P08913       354 vgaakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAv--gCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNh 431 human
NP_001072843 336 ernpkvsrwkgrqNREKRFTFVLAVVIGVFVICWFPFFFTYTLMAvcvrCYVPAPLFKFFFWFGYCNSSLNPFIYTIFNh 415 western clawed ...
Q90WY4       291 cqttkasrwkgrqNREKRFTFVLAVVIGVFVICWFPFFFTYTFTAfc-dCCVPETLFKFFFWFGYCNSSLNPIIYTIFNn 369 zebrafish
EOB05122     315 erttkgsrwrgrqNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAvcmsCSVPETLFKFFFWFGYCNSSLNPVIYTIFNh 394 mallard
Feature 1              
P08913       432 DFRRAF 437 human
NP_001072843 416 DFRRAF 421 western clawed frog
Q90WY4       370 DFRRSF 375 zebrafish
EOB05122     395 DFRRAF 400 mallard

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