Conserved Protein Domain Family
7tmA_alpha2A_AR

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cd15322: 7tmA_alpha2A_AR 
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.
Statistics
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PSSM-Id: 320445
View PSSM: cd15322
Aligned: 4 rows
Threshold Bit Score: 425.127
Threshold Setting Gi: 68052367
Created: 8-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 1351829    34 LTLVCLAGLLMLLTVFGNVLVIIAVFTSRAlkapQNLFLVSLASADILVATLVIPFSLANEVmgyWYFGkaWCEIYLALD 113
gi 118403818  47 LALITLVGMLMLFTVFGNVLVIIAVFTSRAlkapQNLFLVSLASADILVATLVIPFSLSNEVmgyWYFGkvWCEIYLALD 126
gi 68052367   23 LPLSIAVGLLILLIIFGNVLVIIAVFTSRAlrapQNLFLVSLASADILVATLVMPFSLANELmgmWTFGgvWCEIYLALD 102
gi 483519279  27 VTLISLAGLLMLFTVFGNVLVIIAVFTSRAlkapQNLFLVSLASADILVATLVIPFSLANEVmgyWYFGkvWCEIYLALD 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                       #   
gi 1351829   114 VLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKAIIITVWVISAVISFPPLISIekkgggggpqpaepRCEINdQ 193
gi 118403818 127 VLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekesg----kvempICKINdE 202
gi 68052367  103 VLFCTASITHLCAISLDRYWSITQAiEYNLKRTPQRIKRIIFIVWIIAAVISCPPLITMkks--------egdICDINkE 174
gi 483519279 107 VLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKCIIFIVWVISAVISFPPLISIekksgqq-tdqgvaLCKINdE 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  ##  #                                                                     
gi 1351829   194 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdavaappggterrpnglgpersagpggaeaeplptql 273
gi 118403818 203 KWYIIYSSIGSFFAPCVIMVLVYIRIYQIAKkrtrvppgkrsnaaevgakqhnglaekdlpvklngdkaggsggdhgkev 282
gi 68052367  175 KWYIVSSCIGSFFLPCIIMVLVYIRIYQIAKkrtrappgdhrknevgkkendpheklngiqnaepddkdeingvdmeess 254
gi 483519279 186 KWYIISSSIGSFFAPCLIMILVYVRIYQIAKrrtrvppnkraerpekkqngladkedlpataqlngekaagggdgqegev 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1351829   274 ngapgepapagprdtdaldleessssdhaerppgprrpergprgkgkarasqvkpgdslprrgpgatgigtpaagpgeer 353
gi 118403818 283 eangvdmdd---------------------------ssssehqednqyqarkkqdklprgkgktklsqikpgdslprree 335
gi 68052367  255 --------------------------------------------ssdhkvsnpcslkkksskgktklsqikpgdgdktea 290
gi 483519279 266 ngidmee-------------------------------tsssehqdnnqskkserpsrgkaktklsqikpgdslprkvee 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #  ##  #               #   #   #               
gi 1351829   354 vgaakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAv--gCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNh 431
gi 118403818 336 ernpkvsrwkgrqNREKRFTFVLAVVIGVFVICWFPFFFTYTLMAvcvrCYVPAPLFKFFFWFGYCNSSLNPFIYTIFNh 415
gi 68052367  291 cqttkasrwkgrqNREKRFTFVLAVVIGVFVICWFPFFFTYTFTAfc-dCCVPETLFKFFFWFGYCNSSLNPIIYTIFNn 369
gi 483519279 315 erttkgsrwrgrqNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAvcmsCSVPETLFKFFFWFGYCNSSLNPVIYTIFNh 394

                 ....*.
Feature 1              
gi 1351829   432 DFRRAF 437
gi 118403818 416 DFRRAF 421
gi 68052367  370 DFRRSF 375
gi 483519279 395 DFRRAF 400

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