Conserved Protein Domain Family
7tmA_alpha1B_AR

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cd15326: 7tmA_alpha1B_AR 
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors
The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.
Statistics
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PSSM-Id: 320449
View PSSM: cd15326
Aligned: 4 rows
Threshold Bit Score: 484.396
Threshold Setting Gi: 47212001
Created: 13-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 116241241  46 ISVGLVLGAFILFAIVGNILVILSVACNRHlrtpTNYFIVNLAMADLLLSFTVLPFSAALEVlGYWVLGriFCDIWAAVD 125
gi 465989677  50 IIVGLVLGAFILFAIVGNILVILSVACNRHlripTNYFIVNLAIADLLLSFTVLPFSATLEIlGYWVLGriFCDIWAAVD 129
gi 47212001   46 IPLGLVLGAFIVFAIAGNILVILSVVCNRHlrtpTNYFIINLAIADLLLSTTVLPVSATLEIlNYWVFGriFCDIWAAVD 125
gi 512882669  45 MLLGFTLGAFISVAIIGNIMVIISVVTNKQlripTNYLIVNLAIADLLLSSTVLPFSATKEIvGYWVFGriLCDVWAAMD 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                  #      # 
gi 116241241 126 VLCCTASILSLCAISIDRYIGVRYSLqYPTLVtRRKAILALLSVWVLSTVISIGPLLGWKEpapnDDKECGVteEPFYAL 205
gi 465989677 130 VMCCTASILSLCAISIDRYIGVSYSLqYPTLVtRRKAILALLSVWVLSTVISIGPLLGWKEpapkDDKECRIteEPFYAL 209
gi 47212001  126 VLCCTASIMSLCVISIDRYIGVSHPLqYPGIVtEKRALLAMLGVWALSVVISIGPLFGWKQppspDDTVCPIteEPFYAL 205
gi 512882669 125 VLCCTASIFSLCTISIDRYIGVRHSLrYPTIVtRKRTILALLGVWMFSTVISIGPLLGWKEpappDTYVCEIttEIFYAI 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                                                          
gi 116241241 206 FSSLGSFYIPLAVILVMYCRVYIVAkrttknleagvmkemsnskeltlrihs---------knfhedtlsstkakghnpr 276
gi 465989677 210 FSSLGSFYIPLIVILVMYCRVYIVAkrttknleagalkemcdskeltlrihs---------rnihedtfnsskakghhpr 280
gi 47212001  206 FSSLGSFYIPLVVILAMYCRVYIVAkrttknleagvmrermnsseltlrihkgsqvneesghaatatgtgtgkgrahqar 285
gi 512882669 205 FSSLASFYIPLIVILVMYCRVYVVAkritknleagvmkermdskeltlrihc---------rnkqddspnnskvqnnqpr 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #  ##  #               #   #   #                  
gi 116241241 277 ssiavklFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLfstlkpPDAVFKVVFWLGYFNSCLNPIIYPCSSkEFK 356
gi 465989677 281 nsiafklFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLfsalkpPETIFKIIFWLGYFNSCLNPIIYPCSSkEFK 360
gi 47212001  286 ssltvklLKFSREKKAAKTLGVVVGMFTLCWLPFFLALPIGSFnvnlrpPEILFKVIFWLGYFNSCLNPIIYPCYSrEFK 365
gi 512882669 276 salslklLKFSREKKAAKTLGIVVGMFILCWLPFFTVLPLSSLsehltpPVTLEKIIFWLGYFNSCINPIIYPCSSkEFK 355

                 ...
Feature 1           
gi 116241241 357 RAF 359
gi 465989677 361 RAF 363
gi 47212001  366 LAF 368
gi 512882669 356 RAF 358

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