Conserved Protein Domain Family
7tmA_5-HT5

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cd15328: 7tmA_5-HT5 
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors
5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.
Statistics
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PSSM-Id: 320451
View PSSM: cd15328
Aligned: 6 rows
Threshold Bit Score: 464.809
Threshold Setting Gi: 529445490
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications dihydroergotamine and ergotamine.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     ## 
gi 1345607    41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRvPHNLVASMAVSDVLVAALVMPLSLVHELs-gRRWQLGRrLCQLWIA 119
gi 543730     53 VLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRvPHNLVASTAVSDVLVAALVMPLSLVSELsagRRWQLGRsLCHVWIS 132
gi 120537569  31 VLTLTLLAMLVVATFVWNLLVLVTILRVRTFHRvPHNLVASMAISDVMVAGLVMPLSLVRELy-gRRWILGRaLCQVWIS 109
gi 529445490  55 ILVLTLLVLLTVATFLWNLLVLATILRVKAFHRvPHNLVASTAVSDVLVAALVMPLSLVKELsagQRWRLGReLCLVWVC 134
gi 50732639   39 VLVLTLLAMLVVATFLWNGLVLATIFRVRTFHRvPHNLVASMAISDVMVAALVMPLSLVHELs-gRRWWLGRsLCQVWIS 117
gi 512849342  36 VLILTLLAMLVIATFLWNVLVLVTILRVRTFHRvPHNLVASMAISDVMVAALVMPLSLVHELn-dRRWRLGRvLCHIWIS 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  ##                                                                 #       
gi 1345607   120 CDVLCCTASIWNVTAIALDRYWSITRHmeYTLRTRKCVSNVMIALTWALSAVISLAPLlFGWGETYSegsEECQVSrEPS 199
gi 543730    133 FDVLCCTASIWNVAAIALDRYWTITRHlqYTLRTRRRASALMIAITWALSALIALAPLlFGWGEAYDarlQRCQVSqEPS 212
gi 120537569 110 CDVLCCTASIWNVTAIALDRYWSITRHleYTLKTRKRISNVMIGLTWLLSSVISLSPL-FGWGETYSedsLACQVSqEPS 188
gi 529445490 135 FDVLCCTASIWNVTAIALDRYWSITRHlqYTLVTRRRISNFMIALTWVLSAAISLAPL-FGWGETYSpeqERCQVSqEPS 213
gi 50732639  118 FDVLCCTASIWNVTAIALDRYWSITRHleYTLRTRRRISNIMIALTWVLSAFISLAPLlFGWGETYSedsEECQVSqEPS 197
gi 512849342 115 FDVLCCTASIWNVTAIALDRYWSITRHleYTLKTRKRISNIMILLTWLLSAVISLSPL-FGWGETYSevnEECQVSqEPS 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #   #                                                                       
gi 1345607   200 YAVFSTVGAFYLPLCVVLFVYWKIYKAAkfrvgsrktnsvspiseavevkdsa-kqpqmvftvrhatvtfqpegdtwreQ 278
gi 543730    213 YAVFSTCGAFYVPLAVVLFVYWKIYKAAkfrfgrrrravvplpattqakeapq-esetvftarcratvafqtsgdswreQ 291
gi 120537569 189 YTVFSTFGAFYLPLCVVLFVYWKIYKAAkfrigsrktntitpmaevievkeae-rqpqmaftvrhatvsfqtdgetwreQ 267
gi 529445490 214 YTIVSTGGAFYLPLCVVLFVYWKIYKAArfrgggrrrnavvpvpeaaqvkeas-hepqmvftarhaaitfqtdgetwreQ 292
gi 50732639  198 YTIFSTFGAFYLPLCVVLFVYWKIYKAAkfrigsrksnsitpvspeapeikeaaqqpqmvftvrhatvtfqtdgdtwreQ 277
gi 512849342 194 YTIFSTFGAFYLPLCVVLFVYWKIYKAAkfrigskktntitpmpevievkeas-hqpqmvftvrhatvtfqtdgdtwreQ 272
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                           #  ##     #        #  ##  #   #                     
gi 1345607   279 KEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCdiPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
gi 543730    292 KEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACslPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 362
gi 120537569 268 KERRAALMVGILIGVFVLCWIPFFLAELIIPLCSCdiPPVWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAF 338
gi 529445490 293 KEKKAALMVGILIGVFVLCWIPFFITELISPLCSCniPPVWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 363
gi 50732639  278 KERRAALMVGILIGVFVLCWIPFFITELISPLCSCdiPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 348
gi 512849342 273 KEKKAALMVGILIGVFVLCWIPFFITELINPLCSCdiPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 343

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