Conserved Protein Domain Family
7tmA_5-HT5

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cd15328: 7tmA_5-HT5 
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors
5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.
Statistics
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PSSM-Id: 320451
Aligned: 6 rows
Threshold Bit Score: 464.809
Created: 13-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications dihydroergotamine and ergotamine.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     ## 
P47898        41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRvPHNLVASMAVSDVLVAALVMPLSLVHELs-gRRWQLGRrLCQLWIA 119 human
P35365        53 VLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRvPHNLVASTAVSDVLVAALVMPLSLVSELsagRRWQLGRsLCHVWIS 132 Norway rat
AAI29144      31 VLTLTLLAMLVVATFVWNLLVLVTILRVRTFHRvPHNLVASMAISDVMVAGLVMPLSLVRELy-gRRWILGRaLCQVWIS 109 zebrafish
XP_005242455  55 ILVLTLLVLLTVATFLWNLLVLATILRVKAFHRvPHNLVASTAVSDVLVAALVMPLSLVKELsagQRWRLGReLCLVWVC 134 peregrine falcon
XP_425970     39 VLVLTLLAMLVVATFLWNGLVLATIFRVRTFHRvPHNLVASMAISDVMVAALVMPLSLVHELs-gRRWWLGRsLCQVWIS 117 chicken
XP_002932543  36 VLILTLLAMLVIATFLWNVLVLVTILRVRTFHRvPHNLVASMAISDVMVAALVMPLSLVHELn-dRRWRLGRvLCHIWIS 114 western clawed ...
Feature 1         ##  ##                                                                 #       
P47898       120 CDVLCCTASIWNVTAIALDRYWSITRHmeYTLRTRKCVSNVMIALTWALSAVISLAPLlFGWGETYSegsEECQVSrEPS 199 human
P35365       133 FDVLCCTASIWNVAAIALDRYWTITRHlqYTLRTRRRASALMIAITWALSALIALAPLlFGWGEAYDarlQRCQVSqEPS 212 Norway rat
AAI29144     110 CDVLCCTASIWNVTAIALDRYWSITRHleYTLKTRKRISNVMIGLTWLLSSVISLSPL-FGWGETYSedsLACQVSqEPS 188 zebrafish
XP_005242455 135 FDVLCCTASIWNVTAIALDRYWSITRHlqYTLVTRRRISNFMIALTWVLSAAISLAPL-FGWGETYSpeqERCQVSqEPS 213 peregrine falcon
XP_425970    118 FDVLCCTASIWNVTAIALDRYWSITRHleYTLRTRRRISNIMIALTWVLSAFISLAPLlFGWGETYSedsEECQVSqEPS 197 chicken
XP_002932543 115 FDVLCCTASIWNVTAIALDRYWSITRHleYTLKTRKRISNIMILLTWLLSAVISLSPL-FGWGETYSevnEECQVSqEPS 193 western clawed ...
Feature 1            #   #                                                                       
P47898       200 YAVFSTVGAFYLPLCVVLFVYWKIYKAAkfrvgsrktnsvspiseavevkdsa-kqpqmvftvrhatvtfqpegdtwreQ 278 human
P35365       213 YAVFSTCGAFYVPLAVVLFVYWKIYKAAkfrfgrrrravvplpattqakeapq-esetvftarcratvafqtsgdswreQ 291 Norway rat
AAI29144     189 YTVFSTFGAFYLPLCVVLFVYWKIYKAAkfrigsrktntitpmaevievkeae-rqpqmaftvrhatvsfqtdgetwreQ 267 zebrafish
XP_005242455 214 YTIVSTGGAFYLPLCVVLFVYWKIYKAArfrgggrrrnavvpvpeaaqvkeas-hepqmvftarhaaitfqtdgetwreQ 292 peregrine falcon
XP_425970    198 YTIFSTFGAFYLPLCVVLFVYWKIYKAAkfrigsrksnsitpvspeapeikeaaqqpqmvftvrhatvtfqtdgdtwreQ 277 chicken
XP_002932543 194 YTIFSTFGAFYLPLCVVLFVYWKIYKAAkfrigskktntitpmpevievkeas-hqpqmvftvrhatvtfqtdgdtwreQ 272 western clawed ...
Feature 1                           #  ##     #        #  ##  #   #                     
P47898       279 KEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCdiPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349 human
P35365       292 KEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACslPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 362 Norway rat
AAI29144     268 KERRAALMVGILIGVFVLCWIPFFLAELIIPLCSCdiPPVWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAF 338 zebrafish
XP_005242455 293 KEKKAALMVGILIGVFVLCWIPFFITELISPLCSCniPPVWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 363 peregrine falcon
XP_425970    278 KERRAALMVGILIGVFVLCWIPFFITELISPLCSCdiPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 348 chicken
XP_002932543 273 KEKKAALMVGILIGVFVLCWIPFFITELINPLCSCdiPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 343 western clawed frog

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