Conserved Protein Domain Family
7tmA_5-HT1A_vertebrates

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cd15330: 7tmA_5-HT1A_vertebrates 
serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors
The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.
Statistics
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PSSM-Id: 320453
View PSSM: cd15330
Aligned: 4 rows
Threshold Bit Score: 476.008
Threshold Setting Gi: 270311548
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications dihydroergotamine and ergotamine.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   ##  #
gi 231454     37 VITSLLLGTLIFCAVLGNACVVAAIALERSLQnvANYLIGSLAVTDLMVSVLVLPMAALYQVLnkWTLGqvtCDLFIALD 116
gi 6224982    46 IITSLFLGALILCSIFGNSCVVAAIALERSLQnvANYLIGSLAVTDLMVSVLVLPMAALYQVLnkWTLGqdiCDLFIALD 125
gi 82246556   31 IIASLFLGRSFSAGIFGNACVIAAIALERSLQnvANYLIGSLAVTDLMVSVLVLPMAAQNQVLnkWTLGqvtCDIFISLD 110
gi 270311548  31 LLTSLLLGTLILCAVSGNACVIAAIALERSLQtvANYLIGSLAVTDLMVSVLVLPMAALYQVLnkWTLGqviCDIFISLD 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                 #         
gi 231454    117 VLCCTSSILHLCAIALDRYWAITDPiDYVNKRtPRRAAALISLTWLIGFLISIPPMLGWRTPEDrsdPDACTIskDHGYT 196
gi 6224982   126 VLCCTSSILHLCAIALDRYWAITDPiDYVNKRtPRRAAVLISVTWLIGFSISIPPMLGWRSAEDranPDACIIsqDPGYT 205
gi 82246556  111 VLCCTSSILHLCAIALDRYWAITDPiDYVNKRtPRRAAVLISITWIVGFSISIPPMLGWRTPEDrsdPNACRIseDPGYT 190
gi 270311548 111 VLCCTSSILHLCAIALDRYWAITDPiDYVNKRtPRRAAVLISLTWLIGFLISIPPMLGWRTPEDrsnPDACTIskDHGYT 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #   #                                                                         
gi 231454    197 IYSTFGAFYIPLLLMLVLYGRIFRAArfrirktvkkvektgadtrhgaspapqpkksvngesgsrnwrlgveskaggalc 276
gi 6224982   206 IYSTFGAFYIPLILMLVLYGRIFKAArfrirktvkktekakasdmcltlspavfhkrangdavsaewkrgykfkpsspca 285
gi 82246556  191 IYSTFGAFYIPLILMLVLYGKIFKAArfrirktvkkaekkkvadtclsvsqqspkekqrgaqqeleevggaqaqrcvnga 270
gi 270311548 191 IYSTFGAFYIPLLLMLVLYGRIFKAArfrirktvkkaekkkiadtcltlspaalqkksngepgkgwrrtveprsgacvng 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 231454    277 angavrqgddgaalevievhrvgnskehlplpseagptpcapasferknernaeakrkmalARERKTVKTLGIIMGTFIL 356
gi 6224982   286 --------ngavrhgeemesleiievnsnskthlplpntpqsssheninekttgtrrkialARERKTVKTLGIIMGTFIF 357
gi 82246556  271 -------irhgeegavleiievhhyvnskchlhckpvpppeqlppalkndrateakrkvalARERKTVKTLGIIMGTFIL 343
gi 270311548 271 av---rqgedgaalevievqrcsssskthlplpseacgsppppsferrneknteakrrmalSREKKTVKTLGIIMGTFIL 347
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1         #  ##     #          #  ##  #   #                     
gi 231454    357 CWLPFFIVALVLPFCessCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAF 411
gi 6224982   358 CWLPFFIVALVLPFCaenCYMPEWLGAVINWLGYSNSLLNPIIYAYFNKDFQSAF 412
gi 82246556  344 CWLPFFIVALVLPFCe-tCHMPHLLFDIITWLGYSNSLLNPIIYAYFNKDFQSAF 397
gi 270311548 348 CWLPFFIVALVLPFCdskCYMPEWLGAVINWLGYSNSLLNPIIYAYFNKDFQSAF 402

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