4IAR,4IAQ


Conserved Protein Domain Family
7tmA_5-HT1B_1D

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cd15333: 7tmA_5-HT1B_1D 
Click on image for an interactive view with Cn3D
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors
The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.
Statistics
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PSSM-Id: 320455
View PSSM: cd15333
Aligned: 10 rows
Threshold Bit Score: 432.297
Threshold Setting Gi: 2494925
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4IAQ: Human 5-HT1B G protein-coupled receptor binds the agonist antimigraine medication dihydroergotamine, contacts at 4A.
    View structure with Cn3D
  • Structure:4IAR: Human 5-HT1B binds ergotamine, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
4IAR_A        17 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTgRWTLGQVVCDFW 96
gi 514739003  19 LSGKIVLAVVLALVTLATVLSNAFVIATVYQTRKLHTPANYLIASLAVTDLLVSILVMPISTVYTVTgKWTLGQIVCDIW 98
gi 112821     46 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTgRWTLGQVVCDFW 125
4IAQ_A        17 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTgRWTLGQVVCDFW 96
gi 512841768  42 SFSKIILTVILALITLATLLSNAFVITTVYQTRKLHTPANYLIASLAFTDLLVSILVLPIAIVYTVTgKWTLGQIICDMW 121
gi 410915987  36 VAVQAGVAVTLALITFATTLSNAFVIATIYQSRKLHTPANFLIASLAVTDLLVSILVMPISALYTVSqTWTLGQVMCDIW 115
gi 112819     35 QALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIThTWNFGQILCDIW 114
gi 363742200  35 LGLKISLSVLLSVITLATILANVFVVITIFLTRKLHTPANYLIGSLAVTDLLVSVLVMPISIAYTVThTWAFGQVLCDIW 114
gi 512825217  10 LGLKITLAVLLSIITLATLLSNVFVIITIVMTRKLHTPANYLIGSLAFTDLLVSILVMPISIAYTVThTWTFGQIVCDIW 89
gi 2494925    33 LGLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLAVTDMLVSILVMPISIVYTVSkTWSLGQIVCDIW 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##  ##                                                                #      
4IAR_A        97 LSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEevsECVVNTDH 176
gi 514739003  99 LSSDITCCTASILHLCVIALDRYWAITDAVEYSTKRTPKRAAGMIALVWVFSICISMPPLFWRQAKAEEv-sHCVVNTDH 177
gi 112821    126 LSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEevsECVVNTDH 205
4IAQ_A        97 LSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEevsECVVNTDH 176
gi 512841768 122 LSSDITCCTASILHLCVIALDRYWAITDAVEYTKKRTPKRAVVMIALVWVFSISISMPPLFWRQSKAEEi-aVCAVNTDH 200
gi 410915987 116 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPARAAGMIATAWVIAISISLPPFFWRQVKAEEv-tSCNVNSDH 194
gi 112819    115 LSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEemsDCLVNTSQ 194
gi 363742200 115 LSSDITCCTASILHLCVIALDRYWAITDALEYAKRRTAGRAMLMIAVVWMISISISVPPFFWRQVKAHEeiaKCNVNTDQ 194
gi 512825217  90 LLSDITCCTASILHLCVIALDRYWAITDALEYTKHRTARRAAVMILVVWIISICISIPPLFWRQAKAHEeltVCTINTDQ 169
gi 2494925   113 LSSDITFCTASILHLCVIALDRYWAITDALEYSKRRTMRRAAVMVAVVWVISISISMPPLFWRQAKAHEelkECMVNTDQ 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #   #                                                                     
4IAR_A       177 ILYTVYSTVGAFYFPTLLLIALYGRIYVEARsriadlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatpp 256
gi 514739003 178 VLYTVYSTVGAFYFPTLLLIALYGRIYVEARsrilkqtpkkagkrltraqlitdspgssssvtsin-------------- 243
gi 112821    206 ILYTVYSTVGAFYFPTLLLIALYGRIYVEARsrilkqtpnrtgkrltraqlitdspgstssvtsin-------------- 271
4IAQ_A       177 ILYTVYSTVGAFYFPTLLLIALYGRIYVEARsriadlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatpp 256
gi 512841768 201 ILYTVYSTVGAFYIPTLLLIALYGRIYVEARsrilkqspkttgkrltkahlitdspgsssvsstns-------------- 266
gi 410915987 195 IFYTIYSTFGAFYIPTLLLIALYGRIYVEARkrilkqshnkpgkrltsahlitnspgsvasttslny------------- 261
gi 112819    195 ISYTIYSTCGAFYIPSVLLIILYGRIYRAARnrilnppslygkrfttahlitgsagsslcslnss--------------- 259
gi 363742200 195 ISYTIYSTCGAFYIPTVLLLILYGRIYVAARsrilkppslygkrfttahlitgsagsslcsinas--------------- 259
gi 512825217 170 ISYTIYSTCGAFYIPTVLLILLYGKIYIAARsrilkppsiygkrfttaqlipgstgssfcsinan--------------- 234
gi 2494925   193 ISYTLYSTFGAFYVPTVLLIILYGRIYVAARsrifktpsysgkrfttaqliqtsagsslcslnsasnqe----------- 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
4IAR_A       257 kledks--pdspemkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylaARERKATKTLGIILGAF 334
gi 514739003 244 ----------------------------skapegssetgspvymnqvkvkvsdallekkkltaARERKATKTLGIILGAF 295
gi 112821    272 ----------------------------srvpdvpsesgspvyvnqvkvrvsdallekkklmaARERKATKTLGIILGAF 323
4IAQ_A       257 kledkspdspemkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkyllmaARERKATKTLGIILGAF 336
gi 512841768 267 -----------------------------rtlempsdagspvylnqvkvkvsdallekkkimaARERKATKTLGVILGAY 317
gi 410915987 262 ----------------------------gtndssscdttsspnigqvkvtvsdallekkrisaARERKATKTLGIILGAY 313
gi 112819    260 -----------------------------lheghshsagsplffnhvkikladsalerkrisaARERKATKILGIILGAF 310
gi 363742200 260 -----------------------------lheghshsggspifinhvqikladsilerkrisaARERKATKTLGIILGAF 310
gi 512825217 235 -----------------------------vhmehphtsetpvcinhikikladsiierkrlsaAREKKATKTLGIILGAF 285
gi 2494925   262 --------------------------ahlhsgaggegggsplfvnsvkvkladnvlerkrlcaARERKATKTLGIILGAF 315
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1           #  ##     #           #  ##  #   #                            
4IAR_A       335 IVCWLPFFIISLVMPICKD-ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 391
gi 514739003 296 IVCWLPFFIISLVLPICKD-ACWFHMAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 352
gi 112821    324 IVCWLPFFIISLVMPICKD-ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 380
4IAQ_A       337 IVCWLPFFIISLVMPICKD-ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 393
gi 512841768 318 IVCWLPFFIISLVMPICKD-ACWFHPAIFDFFNWLGYLNSLINPIIYTMSNEd-------FKQAF 374
gi 410915987 314 IVCWLPFFIYTLLVPVCPScFYPELFDSFTWLGYLNSLINPIIYTMSNEDFKqafhklirFKCCR 378
gi 112819    311 IICWLPFFVVSLVLPICRD-SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEe-------FRQAF 367
gi 363742200 311 IFCWLPFFVMSLVLPICQD-ACWFHPILLDFFTWLGYLNSLINPVIYTAFNEe-------FKQAF 367
gi 512825217 286 IVCWLPFFVVSLVLPICRD-ACWFDPLLFDFFTWLGYLNSLINPVIYTVFNEd-------FKKAF 342
gi 2494925   316 IICWLPFFVVTLVWAICKE-CSFDPLLFDVFTWLGYLNSLINPVIYTVFNDE--------FKQAF 371

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