Conserved Protein Domain Family
7tmA_5-HT1F

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cd15334: 7tmA_5-HT1F 
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors
The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.
Statistics
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PSSM-Id: 320456
View PSSM: cd15334
Aligned: 4 rows
Threshold Bit Score: 428.598
Threshold Setting Gi: 47226259
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications dihydroergotamine and ergotamine.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   ##  #
gi 398967     24 ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVrESWIMGQvvCDIWLSVD 103
gi 47226259   31 ILLTVTLFIVAILTTFLNCLVITAIAVTRKLHHPANYLICSLAVTDLLVAVLVMPFSIMYIQkETWVMGQvmCTIWLSVD 110
gi 449283864  24 ILISITLSVLALMTTAINSLVMTAIIVTRKLHHPANYLICSLAVTDFLVAILVMPFSIVYIVkETWIMGQvvCDIWLSVD 103
gi 301604331  24 ILISLTLSILTLMTTAINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIMkETWIMGQaiCDIWLSVD 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                 #         
gi 398967    104 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHqgt--srDDECIIkHDHIVS 181
gi 47226259  111 VTCCTCSILHLAAIAIDRYRAITDAVEYSRKRTGARAGQMVAVVWLLSILISLPPLLWRHftedseqEDQCIIiHHHIAF 190
gi 449283864 104 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHqtt--srDDECIIkHDHIVF 181
gi 301604331 104 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAAFMIAVVWIISIFISMPPLFWRHqal--nkEDECIIkHDHIVF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #   #                                                                        
gi 398967    182 TIYSTFGAFYIPLALILILYYKIYRAAktlyhkrqasriakeevngqvllesgekstksvstsyvl-------------- 247
gi 47226259  191 TLYSTFGAFYIPLLLILILYYKIYRAAqtlymrreasrasrhscmtngsmipssypagdggprspeplspaekssdpste 270
gi 449283864 182 TIYSTFGAFYIPLALILILYYKIYKAAktfhrrsvsrivreevngqvlldtgerstksasmpsta--------------- 246
gi 301604331 182 TIYSTFGAFYIPLALILILYYKIYKAAktlyhkrsvsrvereqngqvlldatttlciaeksf------------------ 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         #  ##     #    
gi 398967    248 -------ekslsdpstdfdkihstvrslrsefkhekswrrqkisgTRERKAATTLGLILGAFVICWLPFFVKELVVNVCD 320
gi 47226259  271 epprervrapkksfqgksrrfesrrgesrsesrrsqfnqgprisgSRERKAAYTLGLIIGAFIICWLPFFVKEVIVNTCD 350
gi 449283864 247 --------ektsdplvdcdkinislrsprseskhekswkkqrissTRERKAATTLGLILGAFVICWLPFFVKEVVVNTCE 318
gi 301604331 244 -----------sdhstdfdkihitvrnarvemkqekayrkqkissTRERKAATTLGLILGAFVICWLPFFVKEVIVNICE 312
                        330       340       350
                 ....*....|....*....|....*....|....*....
Feature 1             #  ##  #   #                      
gi 398967    321 KCkiSEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQ 359
gi 47226259  351 SCytSVEMADFLTWLGYINSLINPLIYTIFNEDFKKAFQ 389
gi 449283864 319 RChiSEDMSNFLAWLGYINSLINPLIYTIFNEDFKKAFQ 357
gi 301604331 313 SCyiSDDMSNFLTWLGYLNSLINPLIYTIFNEDFKKAFQ 351

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