2ZIY,2Z73


Conserved Protein Domain Family
7tmA_Opsin_Gq_invertebrates

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cd15337: 7tmA_Opsin_Gq_invertebrates 
Click on image for an interactive view with Cn3D
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 320459
View PSSM: cd15337
Aligned: 12 rows
Threshold Bit Score: 420.959
Threshold Setting Gi: 360045130
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2ZIY: Todarodes pacificus rhodopsin binds retinal, contacts at 4A.
    View structure with Cn3D
  • Structure:2Z73: Todarodes pacificus rhodopsin binds retinal, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                             #                       #  
2ZIY_A        34 YSLGIFIGICGIIGCGGNGIVIYLFTKTKSlq-tpANMFIINLAFSDFTFSLVNGFPLMTISCFLkkWIFGfaaCKVYGF 112
2Z73_A        35 YSLGIFIGICGIIGCGGNGIVIYLFTKTKSlq-tpANMFIINLAFSDFTFSLVNGFPLMTISCFLkkWIFGfaaCKVYGF 113
gi 3024254    52 YIIGVYITIVGLLGIMGNTTVVYIFSNTKSlr-spSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHqkWIFGslfCQLYGF 130
gi 8132429    37 YLVGIYIGIVGILAVMGNSLVITLFLLCKQlr-tpPNMLIVSLAISDFSFALINGFPLKTIAAFNhrWGWGklaCELYGF 115
gi 19309911   52 YAVAAWMTFFGILGVSGNLLVVWTFLKTKSlr-taPNMLLVNLAIGDMAFSAINGFPLLTISSINkrWVWGklwRELYAF 130
gi 405957481  49 YAIGVFISIVGIIGIFGNATVIYIFSTTKNlk-tpSNMFIVNLALSDMIFSLVMGFPLLTISAFNkkWIWGntaCELYGL 127
gi 501418495  56 WVIGVYIAIVGMIGVIGNFLVIFFFSTTRSlr-tpSNLFVINLAISDLGFSAVNGFPLMTISSFMrkWYFGniaCTLYGF 134
gi 478859336  47 ILFGTYISIIGLLAVFGNGLILGVFKRCKAlrlrpSSVLTISLLASDMAFSAVNGFPILTFTSYYkkWIFGstgCQLYAF 126
gi 226479150  37 YAIGLFIAVVGITGMCLNLLVIVFFTMFKAlr-tpSNILVINLAISDFGFSAVIGFPLKTMAAFNnfWPWGktaCTIYGL 115
gi 443703979  47 YGLGLYMAVVGIVGTLGNLVVITLFIKTRSlr-tpPNMFIINLALSDMGFCATNGFPLMTVASFQklWRWGpvaCELYAL 125
gi 360045130  48 YLVAIFVALIGIFGTITNLLVIFVFLTPKSsi-slQCALIINLAISDFGFSAVIGFPLKTIAAFNqyWPWGsvaCQLYGF 126
gi 349922084  56 YLFGAYASIVGVSSIALNSFIILAFSLNGFvr-ktRHWFTVNLAVADLGLTISCCFPLKAISLFRgkWIWGkvgCDFYGF 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #   #                                                                  ###    
2ZIY_A       113 IGGIFGFMSIMTMAMISIDRYNVIGRPmaaskkmsHRRAFIMIIFVWLWSVLWAIGPI--FGWGAYTLEGVLCNCSFDYI 190
2Z73_A       114 IGGIFGFMSIMTMAMISIDRYNVIGRPmaaskkmsHRRAFIMIIFVWLWSVLWAIGPI--FGWGAYTLEGVLCNCSFDYI 191
gi 3024254   131 VGGVFGLMSINTLTAISIDRYVVITKPlqasqtmtRRKVHLMIVIVWVLSILLSIPPF--FGWGAYIPEGFQTSCTFDYL 208
gi 8132429   116 AGSIFGFISLTTMAFIALDRYLVIVQPfetfsritYGKVIVMIFITWIWSALWSIPPF--FGYGSYIPEGFHTSCTFDYL 193
gi 19309911  131 VGGIFGLMSINTLAWIAIDRFYVITNPlgaaqtmtKKRAFIILTIIWANASLWALAPF--FGWGAYIPEGFQTSCTYDYL 208
gi 405957481 128 VGGIFGLMSITTLSAISVDRYYAIAHPlraarnmtRKKAFMMICIVWVWSLCASLPPL--FGWGRYVAEGFQTSCTFDYL 205
gi 501418495 135 LGGIFGFNSIGSLMFISLDRYYVIAKPleamrkatKKRAFLQIIVIWIWALIWSGPPL--IGFGSYIPEGLQTSCSFDYL 212
gi 478859336 127 LGSLFGITSINTMALMAIERYLTIKTNlylmhsgtFKRNLVFVAIAWLWALLIALMPV--LGWGRYVLEGFQTTCSFDYL 204
gi 226479150 116 GGGLFGFVSLSTIAAIAFDRYLVIATPfesvfqttPKRTILIMLFLWLWSLIWTIPPI--FGFGRYVTEGFQTSCTFDYI 193
gi 443703979 126 AGSITGFNSIATLALISMDRYMVIAKPfyamkhvsHKRSLIQIILAWTWAFIWSAPPLlrMGYGRYIPEGFQVSCTFDYL 205
gi 360045130 127 ISATFGFLSLTTIAAISFDRYLVIVKDhkt---tnFRVICTVIGFLWIWSIIWTIPPF--FGFGRYVLEGYQTSCTFDYI 201
gi 349922084 135 AGGLFGFTSITTLAAVAYLRYWTIAHVqpwpyaltNRNATYVLLLIWLWSALWTILPF--FGIGRYVMEGFLTGCAFDYL 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##   #                                                              
2ZIY_A       191 SrdstTRSNILCMFILGFFGPILIIFFCYFNIVMSVsnhekemaamakr---------------lnakelrkaqagaNAE 255
2Z73_A       192 SrdstTRSNILCMFILGFFGPILIIFFCYFNIVMSVsnhekemaamakr---------------lnakelrkaqagaNAE 256
gi 3024254   209 TktarTRTYIVVLYLFGFLIPLIIIGVCYVLIIRGVrrhdqkmltitrs---------------mktedarannkraRSE 273
gi 8132429   194 StdlpNLIFNAGLYILGFLCPVFIIIFSYYQIVKTVrlnelelmkmaqsl--------------dlqnpsamktgdkKAD 259
gi 19309911  209 TqdmnNYTYVLGMYLFGFIFPVAIIFFCYLGIVRAIfahhaemmatakr----------------mgantgkadadkKSE 272
gi 405957481 206 TttpnNRTYIFFLYLFGFAAPLLVIALSYILIIRALkkherkmqqmaak---------------mkvddikanqektKAE 270
gi 501418495 213 TrsptNIAFNMGLFGMGFCFPLLIIIACYVQIIAAVsrqaremqktaek----------------mgaktasddrkkQQE 276
gi 478859336 205 TksanNLSYIMFLMILGFCTPLACITTSYAAIFKKVfsnykvltqaatsngc----------gaglrsgreieekayRTE 274
gi 226479150 194 StdlkNRLFNIGMFGFGFLCPLFLSVFCYARIILIVrsrgkdfiemaassk------------agnqkdksanvsstKSD 261
gi 443703979 206 SrdlkNLIFVWCLFVFGFFIPVLAIACSYVGIIRAVgaqskemrktaek----------------mgaktgksdkekKQD 269
gi 360045130 202 SndmpSLLFSGGMYIFGFMFPVLLCIYCYVNLLKIVrnnervvlislsnd--------------gaskqresvrnrkRLD 267
gi 349922084 213 SndwsSILFSSCLFLGGFVCPFTLICFSYARILWLIrkskqsltqtekvdrkicgnptgqtvidvppsisflqaayrKVS 292
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                         #   #                            #                     
2ZIY_A       256 MRLAKISIVIVSQFLLSWSPYAVVALLAqfgp--lewvTPYAAQLPVMFAKASAIHNPMIYSVSHpkFREAI 325
2Z73_A       257 MRLAKISIVIVSQFLLSWSPYAVVALLAqfgp--lewvTPYAAQLPVMFAKASAIHNPMIYSVSHpkFREAI 326
gi 3024254   274 LRISKIAMTVTCLFIISWSPYAIIALIAqfgp--ahwiTPLVSELPMMLAKSSSMHNPVVYALSHpkFRKAL 343
gi 8132429   260 IEAAKTSIILVLLYLMSWSPYAIVCLMTligs--rdslTPFHSELPVLFAKTSAVYNPIVYAVKHpkFRMEI 329
gi 19309911  273 IQIAKVAAMTIGTFMLSWTPYAVVGVFGmikphsemfiHPLLAEIPVMMAKASARYNPIIYALSHpkFRAEI 344
gi 405957481 271 VKVAKVAIIIVFFYMLSWSPYATVALIGqfgp--aewvTPFLSELPVMLAKASAMHNPIVYALSHpkFREAL 340
gi 501418495 277 IQLAKVAAGTISLFCISWIPYALVAQFGiwgl--rqfvNPITCVVPVLFAKASAMWNPILYALSHprFRAVL 346
gi 478859336 275 LKIIKTAFVVTLAFLLSWLPYTIVAMLGltry--dyliSPYVSQIPVMVAKTSAIYNPIIHVFLYpkLRKAL 344
gi 226479150 262 TFVLKSSAILLGVFLLCWTPYAAICLMAligy--adyiTTTMVELPCLCAKTAAVWDPCIYAFRYprFRAIF 331
gi 443703979 270 IAMAKVAAGTIGLFLMSWTPYAAVSMIGiagn--rswiTPYVSQIPVMFAKASAMWNPILYALSHpkFRAAL 339
gi 360045130 268 IEATKSVILSLLFYLMSWTPYAMVCLISilgq--syflTPTIAEMPHIFAKMAAIYNPILYAFTNrkFKNAL 337
gi 349922084 293 FRTVKTTSILISMYLVAWGPYAVVTLLSvfgy--hnhlTPMGTELPGLFAKTSALYNPIVYMIRNgsFRRTV 362

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