Conserved Protein Domain Family
7tmA_MCHR1

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cd15338: 7tmA_MCHR1 
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320460
View PSSM: cd15338
Aligned: 4 rows
Threshold Bit Score: 455.426
Threshold Setting Gi: 28827160
Created: 14-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #  ##            #####
gi 33860175  110 IIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWcnnvPDIFIINLSVVDLLFLLGMPFMIHQLMGNgvWHFGetmCTLIT 189
gi 465950366  59 VIMPSLFGIICFLGIVGNLIVIYTIVKKKKLRCkqtvPDIFIFNLSIVDLLFLLGMPFLIHQLLGNgaWYFGaplCTIIT 138
gi 118403958  38 VIMPTVFGVICLLGIIGNSVVIYTVFKKSKFRCsssvPDIFIINLSVVDLLFLLGMPFLIHQLLGNgvWHFGetmCTLIT 117
gi 28827160    1 VLMPSIYGVICFVGIIGNCIVIYTIVKKTKFRAqqtvPDIFIFSLCIADLLFLLGMPLLIDQLVGNgfWCFGgtmCTVIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # ##  #                                            # #####                      
gi 33860175  190 AMDANSQFTSTYILTAMAIDRYLATVHPisSTKFRkPSVATLVICLLWALSFISITPVWLYarlipfpgGAVGCGIrlpn 269
gi 465950366 139 ALDTNSQITSTNILTVMTLDRYLATVYPlkSTYVRtPCVAASVICLVWLLSFLTIIPVWMYaglmpledGTVRCALllpn 218
gi 118403958 118 ALDTNSQFTSTYILTAMSIDRYLATVYPftSAKYRkPPIAIMVICILWVLSLLSITPVWMYarlialpgGVLGCGItlpn 197
gi 28827160   81 ELDSNNRIMSTYILTVMTLDRYLATVHPirFNHIRtPRVAVAVVALVWILSLLSITPVWMYaglmplrdGSMGCALllpn 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #  ### ### ##                                                   #  ## ##  # 
gi 33860175  270 pdtDLYWFTLYQFFLAFALPFVVITAAYVRILQRMtssvapasqrsirLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQL 349
gi 465950366 219 petDVYWFTLYQFMLAFAIPLIVICVVYFKILQHMattvvplpqrslqVRTKKVTRMAVAICSAFFICWAPFYILQLVHL 298
gi 118403958 198 pesDIYWYTLYQFFLAFAIPFAVISVAYRRILLKMassealtahrssrIRTKKVTRTAIAICLVFFICWAPFYVLQIIQL 277
gi 28827160  161 patDTYWFTLYQFVLAFALPLVIICVVFFKILQNMaatvaplpqhslrVRTRKVTRMAVAICLAFFICWAPHYILQLAHL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1                ## ###  #  ##                     
gi 33860175  350 sisrptltFVYLYNAAISLGYANSCLNPFVYIVLCetFRKRL 391
gi 465950366 299 gidtpsvaFFYAYNFAISLGYANSCLNPFLYIALSetFKRQF 340
gi 118403958 278 vmdqptlaFHYAYCVAISMGYANSCINPFIYIILCetFRRRF 319
gi 28827160  241 svqrpsyaFLFAYNVAISMGYANSCINPLLYIMLSetFKRQF 282

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