Conserved Protein Domain Family
7tmA_MCHR2

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cd15339: 7tmA_MCHR2 
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320461
View PSSM: cd15339
Aligned: 5 rows
Threshold Bit Score: 416.137
Threshold Setting Gi: 28827166
Created: 14-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##            ###### ##
gi 34098673   35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGgplCTIITSLDT 114
gi 28827166   39 HIFPTIYGILCSVGVIANGLVIYAVTVCKKKMVSDIYVLNLAIADMLFLLVMPFNIHQLVRDrqWVFGnfmCKAVVVVDV 118
gi 449271559  35 IILPSLIGVICSTGLVGNILIVFTIIRTQKKTIPDIYICNLAIADLVHIIGMPFLIHQWARGgeWAFGsplCTIITSLDA 114
gi 567315419  35 VILPSFIGIICSTGLVGNILVLITIIRSRRKTIPDIYICNLAVADLVHIIGMPFLIHQWARGgeWVFGsplCTIITSLDT 114
gi 528504431  47 KILPAFIGFLCSTGLVGNVLVLVTILRSAKKTVPDVYVGNLAVADLVHVIVMPFLIHQWARGghWVFGsslCTIITSLDN 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                         #
gi 34098673  115 CNQFACSAIMTVMSVDRYFALVQPfrLTRWRtRYKTIRINLGLWAASFILALPVWVYskvikfkdGVESCAFDLtspDDV 194
gi 28827166  119 SNQFTTVGIVTVLCIDRYIAIVHP--TSERRtIQWTIIINMLVWLGSFLLTVPVMLYakve-qrqNTEVCMMNLdgpEDM 195
gi 449271559 115 SNQFTCSAIMTAMSLDRYVALVQPfrLTHLRtRSKTIRVNLCLWVASLILMFPVWVYskvikfkdGLESCAFDLtspDNV 194
gi 567315419 115 CNQFACTAIMTAMSLDRYMALVQPfrLTSLRtISKTIRVNVLLWAASFIVVFPVWVYskviqfkdGLESCAFDLttpNDV 194
gi 528504431 127 CNQVACAAVMTAMSLDRYLALVHPfrLLSLRtRSRTIRINLFVWAASFIMVLPAWVHakvirfrdGLESCSLNLvspKQV 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ### ### ##                                                         #  ## ##  #
gi 34098673  195 LWYTLYLTITTFFFPLPLILVCYILILCYtwemyqqnkdarccnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
gi 28827166  196 YWYTLYQSILGFIIPLIIISTFYSLTLYHvfssirr-------vkrkqsVWARRATKMVLMVIGLFLICWSPYHVIQVLN 268
gi 449271559 195 LWYTLYLTITTFFFPLPLIFICYILILCYtwemyqknkkagsyttsiprQRVMRLTKMVLALVSVFVVSAAPFHVIQLMN 274
gi 567315419 195 LWYTLYLTITTFFFPLPLILACYILILCYtwemyhqnksagrynnsiprQRVLRLTKMVLVLVGVYIVSSAPYHVIQIVN 274
gi 528504431 207 LWYTLYQTVTSFFLPLPLILICYILILCYtwrmyrknkkahryntslprERVVRLTKMVLVLVAVFLVSVGPYHILQLVN 286
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
Feature 1                 ## ###  #  ##                     
gi 34098673  275 LqmeqptlaFYVGYYLSICLSYASSSINPFLYILLSgNFQKRL 317
gi 28827166  269 IsnhnptvsFVYAYNISICLSYSHSCINPLMLLIFAqNYRERL 311
gi 449271559 275 LqvsqptltFYLSYYVSICFSYTSSSINPFLYILLSgNFQKRL 317
gi 567315419 275 LqisqpsltFYVSYYCSICLSYASSGINPFLYVLLSgNFRKRL 317
gi 528504431 287 LsvprpslaYHTCYYLSVCLSYAASSINPFIYILLSgHFRHRL 329

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