Conserved Protein Domain Family
7tmA_CB1

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cd15340: 7tmA_CB1 
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.
Statistics
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PSSM-Id: 320462
View PSSM: cd15340
Aligned: 5 rows
Threshold Bit Score: 541.807
Threshold Setting Gi: 82241769
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                  ##  #
gi 115562   117 LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRcrPSYHFIGSLAVADLLGSVIFVYSFIDFhVFHRKDSrnvFLFKLGGV 196
gi 82241769 117 LVIAALSIILGTFTVLENMLVLVVIVQSRSLRcrPSYHFIGSLAVADLLGSVIFVYSFVDFhVFHRKDSpnvFLFKLGGV 196
gi 9789727  119 LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRcrPSYHFIGSLAVADLLGSVIFVYSFVDFhVFHRKDSpnvFLFKLGGV 198
gi 2494952  116 LAVAVLSLTLGTFTVLENLVVLCVIFQSRTLRcrPSYHFIGSLAVADLLGSVIFVYSFLDFhVFHKKDSpnvFLFKLGGV 195
gi 2494953  114 LVIVILAITLGTFTVLENFVVLCVILHSHTLRsrPSYHFIGSLAVADLIGSIIFVYSFLDFhVLHRKDSpsiFLFKLAGV 193
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #  #                                                                            
gi 115562   197 TASFTASVGSLFLTAIDRYISIHRPlaYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCeklqsVCSDIFPHIDETYL 276
gi 82241769 197 TASFTASVGSLFLTAIDRYISIHRPmsYKRIVTRTKAVIAFCMMWTIAIVIAVLPLFGWNCiklrsVCSDIFPLIDETYL 276
gi 9789727  199 TASFTASVGSLFLTAIDRYISIHRPlaYKRIVTRPKAVVAFCVMWTIAIVIAVLPLLGWNCkklnsVCSDIFPLIDETYL 278
gi 2494952  196 TASFTASVGSLFLTAIDRYISIHRPlaYRRIVTRTKAVIAFCMMWTISIIIAVLPLLGWNCkrlnsVCSDIFPLIDENYL 275
gi 2494953  194 IASFTASVGSLFLTAIDRYVSIHRPmaYKRIITKTKAVIAFSVMWAISIEFSLLPLLGWNCkrlhsVCSDIFPLIDEKYL 273
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                            #
gi 115562   277 MFWIGVTSVLLLFIVYAYMYILWKAHSHAVRmiqrgtqksiiihtsedgkvqvtRPDQARMDIRLAKTLVLILVVLIICW 356
gi 82241769 277 MFWIGVTSVLLLFIVYAYMYILWKAHNHAVRmlqrgtqksiivhtsedgkvhitRPDQTRMDIRLAKTLVLILVVLIICW 356
gi 9789727  279 MFWIGVTSILLLFIVYAYMYILWKAHSHAVRmlqrgtqksiiiqstedgkvqitRPDQTRMDIRLAKTLVLILVVLIICW 358
gi 2494952  276 MFWIGVTSVLVLFIIYAYIYILWKAHHHAVRmlsrtsqkslvvysaegtkvqttRPEQTRMDIRLAKTLVLILAVLVICW 355
gi 2494953  274 MFWIGMTTVLLLFIIYAYMFILWKSHHHAVRmlsrssqrsiivytsegtkvqtvRPEQARMDLRLAKTLVLILVALIICW 353
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
Feature 1             #                #  #                         
gi 115562   357 GPLLAIMVYDVFgkmnklIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 408
gi 82241769 357 GPLMAIMVYDVFgkinktIKTVFAFCSVLCLLNSTVNPIIYALRSKDLRNAF 408
gi 9789727  359 GPLLAIMVYDVFgkmnklIKTIFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 410
gi 2494952  356 GPLLAIMVYDLFwkmddnIKTVFAFCSMLCLLNSTVNPIIYALRSRDLRHAF 407
gi 2494953  354 GPLLAIMVYDLFgrvndfIKTVFAFCSMLCLLNSTINPVIYAMRSKDLRRAF 405

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