Conserved Protein Domain Family
7tmA_CB2

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cd15341: 7tmA_CB2 
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.
Statistics
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PSSM-Id: 320463
View PSSM: cd15341
Aligned: 4 rows
Threshold Bit Score: 446.592
Threshold Setting Gi: 465958745
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #                   ##  
gi 223590238  34 IAVAVLCTLMGLLSALENVAVLYLILSSQRLRrKPSYLFIGSLAGADFLASVIFACNFVIFhVFHGVDSr-nIFLLKIGS 112
gi 461697     34 TAVAVLCTLLGLLSALENVAVLYLILSSHQLRrKPSYLFIGSLAGADFLASVVFACSFVNFhVFHGVDSk-aVFLLKIGS 112
gi 465958745  16 TTIALLCSICGILCILENSLVLYLIFASPKIRkKPSYLFISSLALADVLASIVFVCSFLDFhVFNRTDSskeIFLLKLGG 95
gi 301618781  35 IFIAVLCIGAGALCILENTVILCMIWTSSHLRrKPSYIFLMSLALADFLASMVFSYSFVDFhVFHGAGTh-aVFLFKLGG 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                                                           
gi 223590238 113 VTMTFTASVGSLLLTAVDRYLCLCYPptYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCps--pCSELFPLIPNDY 190
gi 461697    113 VTMTFTASVGSLLLTAIDRYLCLRYPpsYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCpr--pCSELFPLIPNDY 190
gi 465958745  96 VNTSFTASLGSLLLMAFDRYVCIYRPseYKVIVTRKRAVVAMAVMWIATIITAFLPLMGWNCCrlnsaCSELFPFVDSKY 175
gi 301618781 114 VTASFTASLGSLLLMAFDRYVSIHKPsmYKSKVTRKRALLALAGMWLITMFIAYLPLMGWNCCqldtsCSELFPLISNNY 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                                                               #      #     
gi 223590238 191 LLGWLLFIAILFSGIIYTYGYVLWKAHQHvaslaehqdrqvpgiaRMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLv 270
gi 461697    191 LLSWLLFIAFLFSGIIYTYGHVLWKAHQHvaslsghqdrqvpgmaRMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLa 270
gi 465958745 176 LSSWICLVMILLLCIVYTYVRVLWKAHKHtvymekrqsqagkrnaKMRMDVTLAKTLVMVLAVVMTCWSPVLALMMYSLf 255
gi 301618781 194 LASWMILVVVLLTLIIYSYAHILWKAHKHavymeqhnmqsgrgqaRLRLDIMLAKTLALVLLVLVICWSPVLILMMHSLl 273
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1                   #  #                         
gi 223590238 271 ttlsDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAA 310
gi 461697    271 ttlsDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSA 310
gi 465958745 256 vsltDHIRKVFAFCSTLCLVNSMVNPIVYALRSRELRSSL 295
gi 301618781 274 fsldRSIKTIFAFCSTLCLVNSMVNPMIYAWRSRELHRKL 313

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