Conserved Protein Domain Family
7tmA_LPAR2_Edg4

?
cd15342: 7tmA_LPAR2_Edg4 
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Statistics
?
PSSM-Id: 320464
View PSSM: cd15342
Aligned: 5 rows
Threshold Bit Score: 456.182
Threshold Setting Gi: 26393399
Created: 25-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human lysophosphatidic acid receptor 1 (LPAR1) in complex with antagonists

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                 #      #   #          ##  ##
gi 26393399   33 VVVVALGLTVSVLVLLTNLLVIAAIASNRRfhqpIYYLLGNLAAADLFAGVAYLFLMFHTgPRTARLSlegWFLRQGLLD 112
gi 55926186   30 MLVVGLGLTVCVFVLLFNLLVIAAIIINRRfhypIYYLLGNLAAADLFAGVAYTYLMFHTgPNTSKLTiktWLVRQSLLD 109
gi 169244235  30 ILVVALGLTVSLIVLLTNLLVIAAIIINRRfhypIYYLLGNLAAADLFAGIAYMFLMFHTgPRTAELSlktWFIRQSLLD 109
gi 83415148   29 KAVVGMGLLVSVFVIFTNILVMAAIFMNRRfhypIYYLLGNLAAADLFAGTSYMYLMFHTgPWTAKLTtyqWFVRQGLID 108
gi 551497952 101 YAVVSLGLLVCFIVILSNLLVISAIFKNRRfhfpIYYLLGNLAVSDLFSGVAYLHLMFHTgPWTMKLSqyqWFLRQGLID 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                                          #  
gi 26393399  113 TSLTASVATLLAIAVERHRSVMAVqLHSRLpRGRVVMLIVGVWVAALGLGLLPahsWHCLCALDRCSRmaplLSRSYLAV 192
gi 55926186  110 TSLTASVANLLAIAVERHQTIFTMqLHSKMsNQRVCILIACIWIIALLLGLIPsfgWSCICNISTCSRmaplYSRSYLIF 189
gi 169244235 110 TSLTASVVNLLAIAVERHQTVLTMqLHSKMsNQRVMILIFCIWATALLLGLIPsygWHCLCALEECSSmaplYSRSYLTF 189
gi 83415148  109 TSLTASVFNLMAIALERHQTIFTMqLHSKMtNHRVVLLILGIWTVAIIMGLVPamgWNCMCDIGNCSTmaplYSRSYLVF 188
gi 551497952 181 TSLTASVLNLLAIAMERHQTIFNMqLHSEMsTRRVFIIIFFIWMVSIIMGLFPtmgWNCLCDLKRCSTmaplYSRSFLVF 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                            #  #  ##           
gi 26393399  193 WALSSLLVFLLMVAVYTRIFFYVRRRvqrmaehvschprYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDglgcesCN 272
gi 55926186  190 WAVSNLVAFLIMMGVYMHIFIYVKRKmtrmsqhtssqpkYRETMINLMKTVFIILSAFVICWTPGQVVLLLDglncksCN 269
gi 169244235 190 WAISNLLVFLLMAVVYAHIFIYVKRKmgrmsahtsfhprYRETVVGLVKTVTIILGAFLIFWTPRQGVLXLDglgcksCN 269
gi 83415148  189 WAAINLLTFTVMVAVYTRIFIYVRRKsqrmsq-htsqvkHKETVVNLMKTVVMILGCFVVCWTPGMVLLLLDglc-rsCD 266
gi 551497952 261 WALINLITFSIMVAIYTRIFFYVRHKsrqmse-httptrHRETVLGLMKTVSMILGLFVLCWTPGLVLLMLDglycetCN 339
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1            ## ##                         
gi 26393399  273 VLAVEKYFLLLAEANSLVNAAVYSCRDaEMRRTF 306
gi 55926186  270 VLAVEKYFLLLAEINSVINPIVYSYRDnEMRNTF 303
gi 169244235 270 VLAGEKYVLLLAEINSLINAIVYSYRDnEMRSXF 303
gi 83415148  267 VLTYEKFFLVLAESNSLMNPIIYSYRDkDMRDTF 300
gi 551497952 340 VLNYEKYFLVLAECNSFVDPIVYCFRDkDMRKTF 373

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap