Conserved Protein Domain Family
7tmA_LPAR3_Edg7

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cd15343: 7tmA_LPAR3_Edg7 
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Statistics
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PSSM-Id: 320465
View PSSM: cd15343
Aligned: 4 rows
Threshold Bit Score: 426.987
Threshold Setting Gi: 402768961
Created: 25-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human lysophosphatidic acid receptor 1 (LPAR1) in complex with antagonists

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                 #      #   #          ##  ##
gi 26393418   31 VIVLCVGTFFCLFIFFSNSLVIAAVIKNRKfhfPFYYLLANLAAADFFAGIAYVFLMFNTgPVSKTLTvnrWFLRQGLLD 110
gi 165973978  31 IGVLCFGTFFCLFIFISNSLVIAAVVKNKRfhfPFYYLLANLAAADFFAGIAYVFLMFHTgPVSKTLTvnrWFLRQGLLD 110
gi 402768961  33 ILVQCVSSICCCFILVANAMIIAAVVTNKRfhyPFYYLLANLAASDFLAGIAYIYLMFNTgKISRDLTvqgYFFRQGLLD 112
gi 301604087  31 IIVLCFGACCCFFIFVSNLLVIAAVVINKRfhyPFYYLLANLAAADFFAGIAYVFLMFHTgPVSKTLTvnrWFLRQGLLD 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                                          #  
gi 26393418  111 SSLTASLTNLLVIAVERHMSIMRMrVHSNLtKKRVTLLILLVWAIAIFMGAVPtlgWNCLCNISACSslapiYSRSYLVF 190
gi 165973978 111 TSLTASLVNLLVIAVERHMSIMRMkIHSNLtKKRVTFLIISIWAIAIFMGAVPtlgWNCLCDISACSslapiYSRSYLVF 190
gi 402768961 113 ASLSASLTNLLVIALERYISIMNFkVHSNLtKRRVTLLIALVWGISIFMGAVPslgWNCICSLDLCSklapiFSRSYLIF 192
gi 301604087 111 TSMSASLANLLVIAVERHISIVRMrIHSNLtKRRVTFLIFLIWAIAIFMGAVPtlgWNCICNITTCSslapiYSRSYLTF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                            #  #  ##           
gi 26393418  191 WTVSNLMAFLIMVVVYLRIYVYVKRKtnvlsphtsgsisRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGlncrqCG 270
gi 165973978 191 WSVLNLVVFFIMVVVYIRIYMYVQRKtnvlsshtsgsisRRRTPVKLMKTVMTLLGAFVVCWTPGLVVLLLDGlnctnCG 270
gi 402768961 193 WSVSNLVLFLIMVGVYVRIYVYVVKKtvvlkahtsgsinRKRTPIKLIKTVMTVLGAFVICWTPGLVVLLLDGlkcerCE 272
gi 301604087 191 WTVSNLAVFVIMLVVYLRIYMYVQRKtnvlsphttgsinRRRTPIKLMKTVMAVLGAFVICWTPGMVVLLLDGlnctkCG 270
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1            ## ##                         
gi 26393418  271 VQHVKRWFLLLALLNSVVNPIIYSYKDedMYGTM 304
gi 165973978 271 IQNVKRWFLLLALLNSVMNPVIYSYKDdeMWGTM 304
gi 402768961 273 VLKFKRWLLLLAVLNSVMNPIIYSYRDeeMWNTI 306
gi 301604087 271 VQHVKRWFLLLALMNSIMNPIIYSYKDeeMWRTF 304

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