Conserved Protein Domain Family
7tmA_S1PR2_Edg5

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cd15347: 7tmA_S1PR2_Edg5 
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Statistics
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PSSM-Id: 320469
View PSSM: cd15347
Aligned: 4 rows
Threshold Bit Score: 435.011
Threshold Setting Gi: 512875115
Created: 25-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                  ##  ##
gi 38257367   34 QVASAFIVILCCAIVVENLLVLIAVARNSKFhsaMYLFLGNLAASDLLAGVAFVANTLLSgSVTLRLTPvQWFAREGSAF 113
gi 465952614  34 DPVSVTIVVLCCLIVLENLLVLLSVYRNKKFhsaMFIFIGNLAFSDLLAGLAFMANVLLSgRYTFSLTPvQWFVREGTAF 113
gi 42559013   54 SSLNILFVVICSIIILENLLVLIAVFRNKKFhsaMFFFIGNLAFSDLLAGSAYIANIFLSgPRTFHLTPvQWFIREGTAF 133
gi 512875115  33 YAISIIFIIICCIIILENLLVLTSVLRNKKFhsaMFFFIGNLAFSDFLTGCAYIANILLSgNMTFTLTPmEWFIREGTAF 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                                             
gi 38257367  114 ITLSASVFSLLAIAIERHVAIAKVkLYGSDKSCRMLLLIGASWLISLVLGGLPilGWNCLghleaCSTVLPLYAKHYVLC 193
gi 465952614 114 ATLAASVLSLLAIAIERHVAITKVkLYGSDKNCRMVLLIGACWVISVAIGGLPimGWNCMgqledCSTVLPLYSKRYILF 193
gi 42559013  134 IALSASVFSLLAIAIERYIAITKVkVYGSNKTCRMFLLIGACWVMSILLGGLPiiGWNCInnlddCSAVLPLNTRYYIRF 213
gi 512875115 113 TTLCASVLSLLAIAIERKVAIMQVeVYSSDRNCRMVLLIAACWVVSIVIGGLPilGWNCIfnmeqCSTVLPLYSKKYILF 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                   #      #                 #  
gi 38257367  194 VVTIFSIILLAIVALYVRIYCVvrsshadmaaPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACpvhsCPILYKAHYF 273
gi 465952614 194 VVTVFTAILLSIVVLYGHIYCIvrsshaeiagTQTLALLKTVTIVLGAFIVCWLPAFIILLLDTSCaikaCPVLYKADYF 273
gi 42559013  214 VVTIFSIILLSIVILYVRIYLIvrtshqeatnSPAYALLKTVTIVLGVFIICWLPAFTILLLDTSCkmkqCPILNNAGIF 293
gi 512875115 193 VVTIFTIILLTIVILYVQIYYIvksshgevaaPPTLALLKTVTIVLGVFIICWLPAFIILLLDVSCkvksCKILYKADYF 272
                        250       260
                 ....*....|....*....|....*.
Feature 1        #                         
gi 38257367  274 FAVSTLNSLLNPVIYTWRSrDLRREV 299
gi 465952614 274 FSFAALNSAVNPVIYTLRSkDMRKEF 299
gi 42559013  294 FSFATLNSALNPLIYTLRSkDMRKEF 319
gi 512875115 273 FGVATLNSALNPIIYTLRSkDMRKEF 298

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