Conserved Protein Domain Family
7tmA_S1PR5_Edg8

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cd15348: 7tmA_S1PR5_Edg8 
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Statistics
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PSSM-Id: 320470
View PSSM: cd15348
Aligned: 4 rows
Threshold Bit Score: 399.968
Threshold Setting Gi: 62510663
Created: 25-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                  ##  ##
gi 62510663   37 RADAVVCLAVCAFIVLENLAVLLVLGRHPRfhapMFLLLGSLTLSDLLAGAAYAANILLSgPLTLKLSPalWFAREGGVF 116
gi 465994502  46 KADAVAFLAICALIVLENLVVLLAIWRNKKfhspMFYLLGNLTLSDLLAGLAYTANIAMSgANTLQLTPllWFLREGGVF 125
gi 187607439  43 KAEAVFFLVVCVFIVLENLIVLLALWRNKKfhspMFYLLGNLTLSDLLAGVAYIVNILMSgANTLRLTPamWFVREGGVF 122
gi 55249643   34 KPEAIAFLIICLLIVVENAIVLVAIWKNKKfhmpMYYLLGSLTLSDLLAGFTYMVNIVTSgANTLKMTPvlWFLREGGVF 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                                             
gi 62510663  117 VALTASVLSLLAIALERSLTMARRgPAPVSSRGRTLAMAAAAWGVSLLLGLLPaLGWNCLgrldaCSTVLPLYAKAYVLF 196
gi 465994502 126 ITLAASVFSLLAIAIERHITMSRMkLYHSDKKGRMFLLVGATWATSVLLGVLPiLGWNCLdslaaCSTLLLLFSKSYILF 205
gi 187607439 123 ITLTASIFSLLAIAIERHITMVRMkHYSGDKKGRMALLIGAAWLVSILLGVLPiLGWNCIsnlqsCSTILPLYSKNYLLV 202
gi 55249643  114 ITLAASVISLLAIAIERHVTMVRMkPYQGAKRGRMFGLIGASWLLSILLGILPiMGWNCIgnldeCSTVLPLYAKSFILF 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                                  #      #     
gi 62510663  197 CVLAFVGILAAICALYARIYCQVRanarrlparpgtagttstrarrkPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVA 276
gi 465994502 206 CITVFLAILVSITVLYARVFRMVKghsprlgsl------rkgmlkrsQKYMALLKTVTIVVGTFVACWLPLFLLLLLDVW 279
gi 187607439 203 CISIFLAILIAIVVLYLRIYRIVKvnsqrlgtl------rkgtlkksQKYMALLKTVTIVVGTFIMCWLPLFVLFLFDVS 276
gi 55249643  194 CITVFTLVLMSIVVLYVRIFRIVKsntqrlgfgt----qrkglarksQKYLALLKTVTIVLGVFIACWLPLFVLLLLDFS 269
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1                    #  #                         
gi 62510663  277 CpartCPVLLQADPFLGLAMANSLLNPIIYTLTNrDLRHAL 317
gi 465994502 280 CeaqaCGVLYKADYFLGLAMINSLLNPIIYTLTSkDMRRAI 320
gi 187607439 277 CevnaCPILLKADYFLGLAMINSLLNPIIYTLTSrDIRRAI 317
gi 55249643  270 CpaqsCEVLFKADYFLGIAMINSLLNPIIYTLTSkDMRRAI 310

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