Conserved Protein Domain Family
7tmA_S1PR4_Edg6

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cd15349: 7tmA_S1PR4_Edg6 
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
Statistics
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PSSM-Id: 320471
View PSSM: cd15349
Aligned: 4 rows
Threshold Bit Score: 380.669
Threshold Setting Gi: 42558945
Created: 25-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #                  ##  #
gi 42558945   47 GALRGLSVAASCLVVLENLLVLAAITSHMRs-rRWVYYCLVNITLSDLLTGAAYLANVLLSgARTFRLApaqWFLREGLL 125
gi 33989496   99 SAVTVLFLCFSVFIILENLMVLLAVLFRVRlrhRWIFICIANIALSDLLTGTSYVVNICMSgEQTFRLTpilWLFREGLL 178
gi 465951182   2 GLLKVAFITISCLIVVENLLVLMAIVRGLHv-rRWVYSCIASITVSDLLAGVAYICNICLSgSRTFQLTpelWFLREGVL 80
gi 301613753  41 GIFHLLGILISVLIILENLSVLLALLRDPRm-rRWVHCCLGNIALSDLLAGISYLLNLFLSgPTTFRLSpalWFLREGLL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                                                            
gi 42558945  126 FTALAASTFSLLFTAGERFATMVRPvaeSGATKTSRVYGFIGLCWLLAALLGMLPllGWNCLCafdrCSSLLPLYSKRYI 205
gi 33989496  179 FVALAASIFSLLLIAVERYATMMKPvhqKTATKTYRVYIMMLLCWITAFIIGFLPlmGWNCVCdlrsCSTLLPLYSKSYI 258
gi 465951182  81 FIALAASTFSLLVTAIERYSTMVRPiaeNEASKTKRLRSLIVSCWALAILIGMLPllGWNCLCdfrsCSTLLPLYSKNYI 160
gi 301613753 120 FTTLAASTFSLLVTAVERYCTMVILvteNNSVKSMRVQGVIVLCWVLAGVVGFLPllGWNCLCkiesCSSLLPLYSRTYL 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                       #      #              
gi 42558945  206 LFCLVIFAGVLATIMGLYGAIFRLvqasgqkaprpaaRRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFgsnlwaqeY 285
gi 33989496  259 LFALVIFFIILLTIGVLYFAIYCHvrsste-tisarsRKRSLRLLKAVISIVGVFMVCWGPLFILLLVDFFcysr-scsP 336
gi 465951182 161 LFCVVMFSMILLGIIGLYASIYHLvrassqqvitrhsRKRSLRLLKTVLMILGAFILCWSPLFALLLLDVFcesq-tckL 239
gi 301613753 200 FFSIILLGVTLLGIIAAYCTIYYLvctsgrrvaetnsSRRSFHLLKTVLIILSAFVICWSPLFFFLIVDFTcspp-sckS 278
                        250       260       270
                 ....*....|....*....|....*....|...
Feature 1            #  #                         
gi 42558945  286 LRGMDWILALAVLNSAVNPIIYSFRSrEVCRAV 318
gi 33989496  337 LFNPEWVIALAVLNSAMNPLIYSFGSlELRKAI 369
gi 465951182 240 LKGMDWALALALLNSAINPLIYSFRSlEVRRAV 272
gi 301613753 279 PLGLEWVLAVAVLNSAINPLIYSFRSsEMRRAV 311

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