Conserved Protein Domain Family
7tmA_MC2R_ACTH_R

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cd15350: 7tmA_MC2R_ACTH_R 
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.
Statistics
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PSSM-Id: 320472
View PSSM: cd15350
Aligned: 5 rows
Threshold Bit Score: 392.607
Threshold Setting Gi: 512850306
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #                       
gi 399002     25 VLPEEIFFTISIVGVLENLIVLLAVFKNKNLQaPMYFFICSLAISDMLGSLYKILENILIIlrnmGYLKPRGSFEttaDD 104
gi 71895735   40 VVPEEVFFTVAAAGILENLLVLVAVIRNKNLHlPMYFFICSLAISDMLGSLYKTLENIFIIlckmGYLTRRGDFEkklDD 119
gi 512850306  31 HVPEVVYLTVSAIGLLENLLVLLAVIKNKNLHlPMYFFICSLAVSDMLFSLYKILETIIIIlaniGFLDRNGPFEkkmDD 110
gi 542238302  15 VVPNPVFFTIGAVSFAENFLVVVAVIRNRNLHsPMYCFICSLAAFHTIASLTKTLENFMIVfadvGHLNKKGSSEttlDD 94
gi 28827140   19 QVPGQVFLVIAVASLSENLLVIVAVIKNKNLHsPMYCFICNLAVFNTISSFSKALENILLLfkdaGRLNLRGPFElkiDD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  ##  #                                                               #      
gi 399002    105 IIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVtMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPL 184
gi 71895735  120 AMDSMFILSLLGSIFSLLAIAADRYITIFYALRYHNIMtLQRALVILAIIWTFCAGSSIAIALFSHEVATVIPFTILFPL 199
gi 512850306 111 VMDWIFVLSLLGSIFSISAIAADRYITVFHALHYHNIMtVKRASVILAVIWTFCGGSGIAIIMLFHDTAMIICLTVMFLL 190
gi 542238302  95 AIDSLLCMSFLGSFFSILAIAVDRYITIFHALQYHNIMtMQRTGAILGIIWTVCGGLGVLMILFFDFKLIMICFVVLFFI 174
gi 28827140   99 IMDSLLCMCFLSSIFSILAIAVDRYISIFHALRYHMLMtMRRVLIILFTIWVLCGTSGALMVGFFEAATVTIFFIVLFFT 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #      #             
gi 399002    185 MLVFILCLYVHMFLLARSHtrki------------stlpRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPsnPYCA 252
gi 71895735  200 MMIFILCLYIHMFLLARSHakkiasl------ptsavhqRTNMKGAITLTIFLGVFLCCWAPFVLHILLARFCPhnPYCA 273
gi 512850306 191 LLVLIVCLYIHMFLLARSHakkiasls----gqwnsvqqRANINGAITLTILLGLFICCWSPFVLHLLLYVLCRynPYCA 266
gi 542238302 175 SLVIICSLYVYMFMLARIHarkiaalpvggrnnhhqqrwGSNMRGAQTVTILFGTLVVCWSPFFFHLVIIMVCPmnPYCE 254
gi 28827140  179 ALLLILLLYVHMFLLARHHanriasmp-----gaqaqhrKSGLRGALTLTIKKGVFVACWAPFSLHLLIMMICPenQYCE 253
                        250       260       270
                 ....*....|....*....|....*....|....*
Feature 1              #  #                         
gi 399002    253 CYMSLFQVNGMLIMCNAVIDPFIYAFRSpELRDAF 287
gi 71895735  274 CYMSIFHVNGTLIMCNAIIDPMIFAFRSpELRSTF 308
gi 512850306 267 CYLSMLNVNGTLILFSSVIDPLIYAFRSpELRNTF 301
gi 542238302 255 CYRSLFQLHVALLTSHALFDPAIYAFRIaELRHTL 289
gi 28827140  254 CYRSLFQLHVVLLVSHAVIDPAINAFRSvELRNTY 288

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