Conserved Protein Domain Family
7tmA_MC3R

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cd15352: 7tmA_MC3R 
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors
The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.
Statistics
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PSSM-Id: 320474
View PSSM: cd15352
Aligned: 4 rows
Threshold Bit Score: 400.419
Threshold Setting Gi: 30725836
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #                       
gi 395398606  39 FIKPEVFLSLGIVSLLENILVILAVVRNGNLHsPMYFFLCSLAVADMLVSVSNALETIMIAivhsdYLTFEDQfiqhmDN 118
gi 60280471   40 VNKTEIFLALGIISLLENILVILAILKNKNLHsPMYFFLCSLAVADLLVSVSNSLETIMIAvvingYLVINDEhlqkmDN 119
gi 3493361    39 FIKAEVFLTLGIISLMENILVILAVLKNGNLHsPMYFFLCSLAVADMLVSTSNALETIMIAilssgYLIIDDHfiqhmDN 118
gi 30725836   39 QIQAEVFLTLGIVSLLENILVISAVVKNKNLHsPMYFFLCSLAAADMLVSVSNSLETIVIAvlnsrLLVASDQlcrlmHN 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  ##  #                                                               #      
gi 395398606 119 IFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMtVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFA 198
gi 60280471  120 VIDTMICISLIASICNLLVIAIDRYITIFYALRYHSIMtVRKAFVLIAIIWVACIVCGVVFIVYSESTTVIVCLITMFFT 199
gi 3493361   119 VFDSMICISLVASICNLLVIAIDRYITIFYALLYHSIMtVKKALTLIVLIWISCIICGIIFIAYSESKTVIVCLITMFFT 198
gi 30725836  119 VCDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIVtVRRALVAIAVIWLVCVVCGIVFIVYSESKTVIVCLITMFFA 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    #      #            
gi 395398606 199 MMLLMGTLYVHMFLFARLHVKRiaalpp----adgvapQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPtnpYC 274
gi 60280471  200 MLVLMATLYVHMFLFARLHVKRiaalp------vdgevQQRTCMKGAITITILLGVFIVCWAPFFLHLILIISCPsnfYC 273
gi 3493361   199 MLFLMASLYVHMFLFARLHVKRiaalp------vdgvpSQRTCMKGAITITILLGVFIVCWAPFFLHLILIISCPmnpYC 272
gi 30725836  199 MLVLMATLYVHMFLLARLHVQRiaalppaapgagnpapRQRSCMKGAVTISILLGVFVCCWAPFFLHLILLVSCPhhpLC 278
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1               #  #                         
gi 395398606 275 ICYTAHFNTYLVLIMCNSVIDPLIYAFRSlELRNTF 310
gi 60280471  274 ARYTSYFNTYMLLIMCNSVIDPLIYAFRSlEMRKTF 309
gi 3493361   273 VCYTSHFNTYLVLIMCNSVIDPLIYAFRSlEMRKTF 308
gi 30725836  279 LCYMSHFTTYLVLIMCNSVIDPLIYACRSlEMRKTF 314

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