Conserved Protein Domain Family
7tmA_MC5R

?
cd15354: 7tmA_MC5R 
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors
The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.
Statistics
?
PSSM-Id: 320476
View PSSM: cd15354
Aligned: 4 rows
Threshold Bit Score: 442.839
Threshold Setting Gi: 156717704
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #                       
gi 729996     37 GIAVEVFLTLGVISLLENILVIGAIVKNKNLHsPMYFFVCSLAVADMLVSMSSAWETITIYllnNKHLVIADAfvrhiDN 116
gi 27545311   39 HIAPEVFLTLGLISLLENILVILAIVKNKNLHsPMYFFVCSLAVADMLVSVSNAWETIVIHllaNRSLVIEDHfirqmDN 118
gi 3061273    37 VIAAEVFLILGIVSLLENILVICAIVKNKNLHsPMYFFVCSLAVADMLVSVSNAWETITIYlinNRHIIMEDAfvrhiDN 116
gi 156717704  37 VIAAEVFLTLGIVSLLENILVIFAIIKNKNLHsPMYFFVCSLAVADMLVSVSNAWETITINlinNRHLIMEETfvrhiDN 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  ##  #                                                               #      
gi 729996    117 VFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMtARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFA 196
gi 27545311  119 VFDSLICISVVGSMWSLLAIAVDRYVTIFYALRYHNIMtVRRAGILIGSIWTFSTSCGIIFIIYSDTKPVVVCLVAMFFA 198
gi 3061273   117 VFDSLICISVVASMCSLLAIAVDRYITIFYALRYHNIMtVKRSGLIIACIWTFCTGCGIIFILYYESTYVIICLITMFFT 196
gi 156717704 117 VFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMtMRRAGIIIACIWTFCTGCGIIFILYYESTYVIICLITMFFT 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #      #                 
gi 729996    197 MLFLLVSLYIHMFLLARTHVKRiaalp-gassaRQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPqnlYCSRFMS 275
gi 27545311  199 MLLMMASLYSHMFLLARSHVKRmaalpgynaniRQRASMKGAVTLTILLGIFIVCWAPFFLHLILMISCPrniYCVCFMS 278
gi 3061273   197 MLFLMVSLYIHMFLLARTHVKKiaalp-gynsvHQRTSMKGAITLTMLLGIFIVCWAPFFLHLILMISCPqnlYCVCFMS 275
gi 156717704 197 MLFLMVSLYIHMFLLARTHVKRiaalp-gynsvHQRTSMKGAITLTILLGIFIVCWAPFFLHLILMISCPqnlYCVCFMS 275
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1          #  #                         
gi 729996    276 HFNMYLILIMCNSVMDPLIYAFRSqEMRKTF 306
gi 27545311  279 HFNMYLILIMCNSVIDPLIYALRSqEMRKTF 309
gi 3061273   276 HFNMYLILIMCNSVIDPLIYAFRSqEMRKTF 306
gi 156717704 276 HFNMYLILIMCNSVIDPMIYAFRSqEMRKTF 306

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap