Conserved Protein Domain Family
7tmA_NTSR2

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cd15356: 7tmA_NTSR2 
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortlin, is not a G protein-coupled receptor.
Statistics
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PSSM-Id: 320478
View PSSM: cd15356
Aligned: 3 rows
Threshold Bit Score: 447.39
Threshold Setting Gi: 311033404
Created: 29-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Rattus norvegicus neurotensin receptor 1 with bound agonist neurotensin peptide, defined at 4A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                       #   ##           
gi 311033404  33 VLFTALYALIWALGAAGNALSAHVVLKARAgr--aGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLgCRG 110
gi 52078097   33 KVFITVLYISSSWWAHGNVLTIQLVLKKQSlhglqGTVHYHLVSLALSDILILVISIPIELYNFIWFHYPWVFGDAvCRG 112
gi 556977476  54 VLFTVVYTLIFFVGTIGNSLTIYLVLKKKSlqnlqSTVHYHLVSLALSDLLILIISVPIELYNFVWVHYPWIFGDLvCRG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                             #                
gi 311033404 111 YYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEletaDGEPEPA 190
gi 52078097  113 YYFFRDICSYATVLNIASLSCERYLAICHPMRAKRVMSKMRTKKILAAIWVSSLIFALPMAFIMGIKYEnmspDGEPDPS 192
gi 556977476 134 YYFLRDICSYATVLNIVSLSFERYLAISNPIRAKRIISKKRTKTLLSLIWLSSIGFALPMAFVMGEKYQletaQGVPNPS 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ####                                                                          
gi 311033404 191 SRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLlalcsqvpststpgsstpsrlellsee-gllsfivwk 269
gi 52078097  193 SLICTSLVSTATLKIFIQVNAFVSFVLPVTLIGGLNCITVSHLvslrsrsslivhssckspraskelrksqsspsnlsri 272
gi 556977476 214 SRVCTALVSNATLKVFIQVNAFVSFLLPLSLISVMNFVIANRLmafckgnsqnilidf---------------------- 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      ##  ## ###  #    #  #   #         
gi 311033404 270 ktfiqggqvslvrhkdvrRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTdpLYNFYHYFYMVTNTLFYV 349
gi 52078097  273 pvggtswkknltvssepnRIQSLQHSIYMLRAIVIAYIVCWLPYHARRLMFCYIPDDDWSgsLYTFYHYFYMLTNTLFYI 352
gi 556977476 272 ---ipdrwnsltvsnepnQIQALKHSVHVLRAIVIAYVMCWLPYHARRLMFCYVPGHAWTdsLYNFYHYFYMLTNTLFYV 348
                        330       340
                 ....*....|....*....|
Feature 1                            
gi 311033404 350 SSAVTPLLYNAVSSSFRKLF 369
gi 52078097  353 SSAVNPVLYNVVSSSFRKLF 372
gi 556977476 349 SSAVNPILYNVVSSTFRRLF 368

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