Conserved Protein Domain Family
7tmA_NMU-R2

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cd15357: 7tmA_NMU-R2 
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.
Statistics
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PSSM-Id: 320479
View PSSM: cd15357
Aligned: 4 rows
Threshold Bit Score: 535.212
Threshold Setting Gi: 556952834
Created: 29-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Rattus norvegicus neurotensin receptor 1 with bound agonist neurotensin peptide, defined at 4A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    #                #  
gi 9082156    43 LPVSVVYVPIFVVGVIGNVLVCLVILQHQAmktPTNYYLFSLAVSDLLVLLLGMPLEVYEMWrNYPFLFGpvgCYFKTAL 122
gi 353336247  43 LPMALVYSVIFVVGVIGNFLVCLVILKHQNmktPTNYYLFSLAVSDLLVLLFGMPLEVYEMWsNYPFLFGpigCYFKTAL 122
gi 301623309  45 LPMTLVYATIFLIGVIGNTLVCLVILKHHNmrtPTNYYLFSLAVSDLLVLLLGMPLEVYEMWsNYPFLFGawgCYFKTVL 124
gi 556952834  43 LPMSLVYAVIFIVGVSGNLLTCFMILKHRNmktPTNYYLFSLAISDLLVLIFGLPIEVYEMWsNYPFLFGdvgCYFKTSL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #                 ###
gi 9082156   123 FETVCFASILSITTVSVERYVAILHPFRAKLQStRRRALRILGIVWGFSVLFSLPNTSIHGIkfhyfpngslVPGSATCT 202
gi 353336247 123 FETVCFASILSVTTVSIERYFAILHPFRAKLEStRKRALRTIVVLWVLSVLFALPNTGTHGImlqyfpngtlVPGSATCT 202
gi 301623309 125 FETVCFASILSVTTVSVERYVAIIHPFQAKLKStRSRALKILVTLWIFSILFSIPNTSTHGIllqyfpngslIPDSATCT 204
gi 556952834 123 FETVCFASILNVTTVSVERYVAIVHPLRAKSNStRERALKIIIVLWVLSVLFSIPNTTIHGIkqsyfpngtlIPDFEICA 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                                               
gi 9082156   203 VIKPmwiYNFIIQVTSFLFYLLPMTVISVLYYLMALRLkkdksleadegnaniqrPCRKSVNKMLFVLVLVFAICWAPFH 282
gi 353336247 203 VVAPmwiYNWIVQITSFLFYVLPMGVISVLYYLMGLRLkgdrsleaeemsvnvqrPSRKSVTKMLFVLVMVFAVCWAPFH 282
gi 301623309 205 VVQPlwiYNCIIQVTSLLFYILPMGVISVLYCLMGIKLrgdhsleadkmsvnvqrPSRKSITKMLFVLVMVFGICWAPFH 284
gi 556952834 203 VVKPlwiYNLVIQITSLLFYVVPMGVISILYYLMGLKLrddkssetnemniniqrPSRKSVTKMLFVLVLVFAICWAAFH 282
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1         ##  ##            #   #                             
gi 9082156   283 IDRLFFSfveewseslaavFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAF 335
gi 353336247 283 IDRLFFSfvvewteplaniFNLIHVVSGVFFYLSSAVNPIIYNLLSQRFRMAF 335
gi 301623309 285 VDRLFFSfvldwteplanaFNLTHVVSGVFFYLSSAVNPLIYNLLSRRFRSAF 337
gi 556952834 283 VDRLFFSfvvvwteqlanvFNLIHVISGVLLYLSSAVNPIIYNIFSRRFRTAF 335

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