Conserved Protein Domain Family
7tmA_LHCGR

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cd15359: 7tmA_LHCGR 
luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.
Statistics
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PSSM-Id: 320481
View PSSM: cd15359
Aligned: 5 rows
Threshold Bit Score: 513.643
Threshold Setting Gi: 3024107
Created: 30-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##                   #
gi 281185513 360 DFLRVLIWLINILAIMGNMTVLFVLLTSRYkltVPRFLMCNLSFADFCMGLYLLLIASVDsqtkgQYYNHAIDWQTGsGC 439
gi 3024107    23 SFLRVLIWFINILALAGNFIVLLVLITSHYkltVPRFLMCNLSFADFCMGLYLLLIASVDaqtsgQYYNHAIDWQTGsGC 102
gi 358247961 373 NFLRVLIWFISILAIAGNAVVLFILLTSHCkltVPRFLMCNLSFADFCMGIYLLLIASVDsqtrsQYYNHAIDWQTGsGC 452
gi 556988383 304 DFLRILIWFINILAITGNIIVLLVLLTSRYkltVPRFLMCNLSFADLCMGLYLLLIASVDsktrsQYYNHAIEWQTGaGC 383
gi 632958544 304 DILRVLIWFINILAIVGNLIVFVVLVISQNkltVQRFLMCNLAFADLCMGLYLLLIAAVDmntksQYYNYAIDWQTGaGC 383
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##### ##  #                                            # #####                  
gi 281185513 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIhLDQKLrLRHAILIMLGGWLFSSLIAMLPLVGvsnYMKVSICFPMDv 519
gi 3024107   103 STAGFFTVFASELSVYTLTVITIERWHTITYAMqLDRKLrLRHAVPIMLGGWVFSILIAVLPLLGvssYMKVSICLPMDi 182
gi 358247961 453 SAAGFFTVFSSELSVYTLTVITLERWHTITYAMqLDRKLrLRHAILIMLGGWIFSLVIAMLPLVGvsnYIKVSICLPMDi 532
gi 556988383 384 NTAGFFTVFASELSVYTLTVITLERWHTITYAMqLERNLrLRHAIMIMIGGWIFSLSMALLPIAGisnYMKVSICLPMDi 463
gi 632958544 384 ASAGFFTVFSSELSVYTLTMITFERWHTITHAMqLDRKLqLRHAVVIMCGGWVFALILAVLPLVGissYMKVSICLPMDv 463
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  ### ### ##                                              #  ## ##  #       
gi 281185513 520 ettLSQVYILTILILNVVAFFIICACYIKIYFAVrnpelmatNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPli 599
gi 3024107   183 etgLSQAYILLILMLNVIAFLVICACYIKIYVAVqnpelvaaNKDTKIAKRMAILIFTDFTCMAPISFFAISAAIKVPli 262
gi 358247961 533 etpLSQAYIIFILVLNVTAFIIICACYIKIYIAVqnpeltptNKDTKLAKKMAVLIFTDFTCMAPISFFAISAAFKVPli 612
gi 556988383 464 etsVSQAYILIILVLNVIAFLVVCICYVKIYLSVqnpdfaakNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPli 543
gi 632958544 464 eslVSQIYVILILVLNVIAFVVICVCYVKIYLAVqnpdfvskGSDTRIAKRMAVLIFTDFTCMAPISFFAISAAFKWPli 543
                        250       260       270
                 ....*....|....*....|....*....|....*
Feature 1         ## ###  #  ##                     
gi 281185513 600 tVTNSKVLLVLFYPINSCANPFLYAIFTKtFQRDF 634
gi 3024107   263 tVTNSKILLVLFYPVNSCANPFLYAIFTKaFQRDF 297
gi 358247961 613 tVTNSKILLVLFYPVNSCANPFLYAIFTKaFRRDF 647
gi 556988383 544 tVTNSKILLVLFYPINSCANPFLYAIFTKaFRRDF 578
gi 632958544 544 tVTNAKILLVLFYPLNSCANPFLYAIFTKaFRRDF 578

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