Conserved Protein Domain Family
7tmA_LGR4

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cd15361: 7tmA_LGR4 
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.
Statistics
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PSSM-Id: 320483
View PSSM: cd15361
Aligned: 4 rows
Threshold Bit Score: 436.216
Threshold Setting Gi: 519882065
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##                   
gi 212286375 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTsl-psSKLFIGLISVSNLFMGIYTGILTFLDavswgrFAEFGIWWETGsG 617
gi 483510117 411 WMIRLTVWFIFLVALFFNLLVMLTIFASCTpl-psSKLFIGLISVSNLFMGVYTGILTFLDavswgrFAEFGIWWETGsG 489
gi 148228589 542 WMIRLTVWFIFLLALIFNVIVIVTMFASCSpl-tsSKLFVGLIAVSNLFMGVYTGILTVLDtvswgqFAEFGIWWETGsG 620
gi 519882065 527 WMIRLTVWFICLVALLFNCLVLAATFSPRTsslspSRFLVALLASANLLTGVYVAALTLLDtvtwgsFAEYGVWWETGaG 606
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###### ##  #                                                    # #####         
gi 212286375 618 CKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMkNGKSNh--------LKQFRVAALLAFLGATVAGCFPLFHrgeysa 689
gi 483510117 490 CRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIkKGKSNr--------QKQFQIAAVLAFLCAMVAGCLPLFHkveysa 561
gi 148228589 621 CKVAGFLAIFSSESAIFFLMLAAIERSLSAKDIIkKEKHQh--------LRKFQVASLLAVLLATAAGCLPLFHvgefss 692
gi 519882065 607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALMgKAGALrsrgerrerRRRFAIAALLLGLVSVAAACLSLYHgsa-mg 685
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #  ### ### ##                                             #  ## ##  
gi 212286375 690 SPLCLPFptgetPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNlekEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 769
gi 483510117 562 SPLCLPFptgetPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNlekEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 641
gi 148228589 693 SPLCLPFptgetPSLGFTVTLVLLNSLAFLIMVITYTKLYCTiekEDLSENAESSMIKHVAWLIFTNCIFFCPVAFFSFA 772
gi 519882065 686 SPLCLPFsegssPGLGFTVALVLMNTLAYLLSAVVYTRLYCRlgrAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA 765
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
Feature 1        #           ## ###  #  ##                     
gi 212286375 770 PLItai---sisPEIMKSVTLIFFPLPACLNPVLYVFFNPkFKEDW 812
gi 483510117 642 PLItai---sisPEIMKSVTLIFFPLPACLNPVLYVFFNPkFKEDW 684
gi 148228589 773 PLItav---yisPEIMKSVTLIFLPLPACLNPVLYVFFNPkFKEDW 815
gi 519882065 766 PLLagtsnavggPEMAKSVTLIFFPLSACLNPVLYVCFSPsFRYDW 811

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