Conserved Protein Domain Family
7tmA_LGR4

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cd15361: 7tmA_LGR4 
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.
Statistics
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PSSM-Id: 320483
Aligned: 4 rows
Threshold Bit Score: 436.216
Created: 15-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##                   
Q9BXB1       539 WMIRLTVWFIFLVALFFNLLVILTTFASCTsl-psSKLFIGLISVSNLFMGIYTGILTFLDavswgrFAEFGIWWETGsG 617  human
EOA99508     411 WMIRLTVWFIFLVALFFNLLVMLTIFASCTpl-psSKLFIGLISVSNLFMGVYTGILTFLDavswgrFAEFGIWWETGsG 489  mallard
NP_001089881 542 WMIRLTVWFIFLLALIFNVIVIVTMFASCSpl-tsSKLFVGLIAVSNLFMGVYTGILTVLDtvswgqFAEFGIWWETGsG 620  African clawed...
E7FE13       527 WMIRLTVWFICLVALLFNCLVLAATFSPRTsslspSRFLVALLASANLLTGVYVAALTLLDtvtwgsFAEYGVWWETGaG 606  zebrafish
Feature 1        ###### ##  #                                                    # #####         
Q9BXB1       618 CKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMkNGKSNh--------LKQFRVAALLAFLGATVAGCFPLFHrgeysa 689  human
EOA99508     490 CRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIkKGKSNr--------QKQFQIAAVLAFLCAMVAGCLPLFHkveysa 561  mallard
NP_001089881 621 CKVAGFLAIFSSESAIFFLMLAAIERSLSAKDIIkKEKHQh--------LRKFQVASLLAVLLATAAGCLPLFHvgefss 692  African clawed...
E7FE13       607 CQVVGFLAVFSSEWAVLLLALAAVERCLAVRALMgKAGALrsrgerrerRRRFAIAALLLGLVSVAAACLSLYHgsa-mg 685  zebrafish
Feature 1                    #  ### ### ##                                             #  ## ##  
Q9BXB1       690 SPLCLPFptgetPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNlekEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 769  human
EOA99508     562 SPLCLPFptgetPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNlekEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFA 641  mallard
NP_001089881 693 SPLCLPFptgetPSLGFTVTLVLLNSLAFLIMVITYTKLYCTiekEDLSENAESSMIKHVAWLIFTNCIFFCPVAFFSFA 772  African clawed...
E7FE13       686 SPLCLPFsegssPGLGFTVALVLMNTLAYLLSAVVYTRLYCRlgrAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA 765  zebrafish
Feature 1        #           ## ###  #  ##                     
Q9BXB1       770 PLItai---sisPEIMKSVTLIFFPLPACLNPVLYVFFNPkFKEDW 812  human
EOA99508     642 PLItai---sisPEIMKSVTLIFFPLPACLNPVLYVFFNPkFKEDW 684  mallard
NP_001089881 773 PLItav---yisPEIMKSVTLIFLPLPACLNPVLYVFFNPkFKEDW 815  African clawed frog
E7FE13       766 PLLagtsnavggPEMAKSVTLIFFPLSACLNPVLYVCFSPsFRYDW 811  zebrafish

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